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Page 1
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschké P, Salomon R, Antignac C, Ornitz DM, Kopan R. Barak H, et al. Dev Cell. 2012 Jun 12;22(6):1191-207. doi: 10.1016/j.devcel.2012.04.018. Dev Cell. 2012. PMID: 22698282 Free PMC article.
The identity of niche signals necessary to maintain embryonic nephron progenitors is unclear. Here we provide evidence that Fgf20 and Fgf9, expressed in the niche, and Fgf9, secreted from the adjacent ureteric bud, are necessary and sufficient to maintain progenitor stemne …
The identity of niche signals necessary to maintain embryonic nephron progenitors is unclear. Here we provide evidence that Fgf20 and …
Genome-wide SNP scan of pooled DNA reveals nonsense mutation in FGF20 in the scaleless line of featherless chickens.
Wells KL, Hadad Y, Ben-Avraham D, Hillel J, Cahaner A, Headon DJ. Wells KL, et al. BMC Genomics. 2012 Jun 19;13:257. doi: 10.1186/1471-2164-13-257. BMC Genomics. 2012. PMID: 22712610 Free PMC article.
This mutation, common to all sc/sc individuals and absent from wild type, is predicted to lead to loss of a highly conserved region of the FGF20 protein important for FGF signalling. ...In addition, we describe a dCAPS genotyping assay based on the mutation, …
This mutation, common to all sc/sc individuals and absent from wild type, is predicted to lead to loss of a highly conserved region o …
Instability restricts signaling of multiple fibroblast growth factors.
Buchtova M, Chaloupkova R, Zakrzewska M, Vesela I, Cela P, Barathova J, Gudernova I, Zajickova R, Trantirek L, Martin J, Kostas M, Otlewski J, Damborsky J, Kozubik A, Wiedlocha A, Krejci P. Buchtova M, et al. Cell Mol Life Sci. 2015 Jun;72(12):2445-59. doi: 10.1007/s00018-015-1856-8. Epub 2015 Feb 18. Cell Mol Life Sci. 2015. PMID: 25854632 Free PMC article.
Stabilization via exogenous heparin binding, introduction of stabilizing mutations or lowering the cell cultivation temperature rescues signaling of unstable FGFs. Thus, the intrinsic ligand instability is an important elementary level of regulation in the FGF signa …
Stabilization via exogenous heparin binding, introduction of stabilizing mutations or lowering the cell cultivation temperature rescu …
A primary luminal/HER2 negative breast cancer patient with mismatch repair deficiency.
Yang X, Smirnov A, Buonomo OC, Mauriello A, Shi Y, Bischof J, Woodsmith J; TOR CENTRE; Melino G, Candi E, Bernassola F. Yang X, et al. Cell Death Discov. 2023 Oct 2;9(1):365. doi: 10.1038/s41420-023-01650-4. Cell Death Discov. 2023. PMID: 37783677 Free PMC article.
Here, we present the case of a 47-year-old woman diagnosed with luminal B breast cancer subtype and provide an in-depth analysis of her gene mutations, chromosomal alterations, mRNA and protein expression changes. We found a point mutation in the FGFR2 gene, which i …
Here, we present the case of a 47-year-old woman diagnosed with luminal B breast cancer subtype and provide an in-depth analysis of her gene …
Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix.
Kalinina J, Byron SA, Makarenkova HP, Olsen SK, Eliseenkova AV, Larochelle WJ, Dhanabal M, Blais S, Ornitz DM, Day LA, Neubert TA, Pollock PM, Mohammadi M. Kalinina J, et al. Mol Cell Biol. 2009 Sep;29(17):4663-78. doi: 10.1128/MCB.01780-08. Epub 2009 Jun 29. Mol Cell Biol. 2009. PMID: 19564416 Free PMC article.
To test the role of dimerization in ligand autoinhibition, we introduced structure-based mutations into the dimer interfaces of FGF9 and FGF20. The mutations weakened the ability of the ligands to dimerize, effectively increasing the concentrati …
To test the role of dimerization in ligand autoinhibition, we introduced structure-based mutations into the dimer interfaces o …
NUMB is a break of WNT-Notch signaling cycle.
Katoh M, Katoh M. Katoh M, et al. Int J Mol Med. 2006 Sep;18(3):517-21. Int J Mol Med. 2006. PMID: 16865239
Notch, FGF and WNT signaling pathways cross-talk during embryogenesis, tissue regeneration and carcinogenesis. Notch-ligand binding to Notch receptors leads to the cleavage of Notch receptors and the following nuclear translocation of Notch intracellular domain (NICD) to i …
Notch, FGF and WNT signaling pathways cross-talk during embryogenesis, tissue regeneration and carcinogenesis. Notch-ligand binding t …
Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms.
Zhang Y, Li S, Yuan L, Tian Y, Weidenfeld J, Yang J, Liu F, Chokas AL, Morrisey EE. Zhang Y, et al. Genes Dev. 2010 Aug 15;24(16):1746-57. doi: 10.1101/gad.1929210. Genes Dev. 2010. PMID: 20713518 Free PMC article.
Endocardial loss of Foxp1 results in decreased Fgf3/Fgf16/Fgf17/Fgf20 expression in the heart, leading to reduced cardiomyocyte proliferation. This loss of myocardial proliferation can be rescued by exogenous Fgf20, and is mediated, in part, by Foxp1 repression of S …
Endocardial loss of Foxp1 results in decreased Fgf3/Fgf16/Fgf17/Fgf20 expression in the heart, leading to reduced cardiomyocyte proli …
Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis.
Speer AL, Al Alam D, Sala FG, Ford HR, Bellusci S, Grikscheit TC. Speer AL, et al. PLoS One. 2012;7(11):e49127. doi: 10.1371/journal.pone.0049127. Epub 2012 Nov 1. PLoS One. 2012. PMID: 23133671 Free PMC article.
We first showed that mouse adult glandular stomach expressed Fgf10, its receptors, Fgfr1b and Fgfr2b, and most of the other FGFR2b ligands (Fgf1, Fgf7, Fgf22) except for Fgf3 and Fgf20. Fgf10 expression was mesenchymal whereas FGFR1 and FGFR2 expression were mostly …
We first showed that mouse adult glandular stomach expressed Fgf10, its receptors, Fgfr1b and Fgfr2b, and most of the other FGFR2b ligand
Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling.
Cohen ED, Wang Z, Lepore JJ, Lu MM, Taketo MM, Epstein DJ, Morrisey EE. Cohen ED, et al. J Clin Invest. 2007 Jul;117(7):1794-804. doi: 10.1172/JCI31731. J Clin Invest. 2007. PMID: 17607356 Free PMC article.
Conversely, Wnt gain of function in these cells led to expansion of Isl-1-positive progenitors with a concomitant increase in FGF signaling through activation of a specific set of FGF ligands including FGF3, FGF10, FGF16, and FGF20. These data reveal what we believe …
Conversely, Wnt gain of function in these cells led to expansion of Isl-1-positive progenitors with a concomitant increase in FGF signaling …
A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.
Xiao Y, Thoresen DT, Miao L, Williams JS, Wang C, Atit RP, Wong SY, Brownell I. Xiao Y, et al. PLoS Genet. 2016 Jul 14;12(7):e1006150. doi: 10.1371/journal.pgen.1006150. eCollection 2016 Jul. PLoS Genet. 2016. PMID: 27414798 Free PMC article.
Additionally, a Shh signaling agonist was sufficient to rescue Merkel cell differentiation in Edar-deficient skin. Moreover, Merkel cells formed in Fgf20 mutant skin where primary hair formation was defective but Shh production was preserved. ...Our findings relate the var …
Additionally, a Shh signaling agonist was sufficient to rescue Merkel cell differentiation in Edar-deficient skin. Moreover, Merkel cells fo …