Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2001 1
2004 5
2011 1
2012 1
2013 1
2014 1
2015 2
2016 2
2017 1
2018 3
2019 4
2020 3
2021 3
2022 1
2023 3
2025 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

31 results

Results by year

Filters applied: . Clear all
Page 1
FHOD1 is upregulated in gastric cancer and promotes the proliferation and invasion of gastric cancer cells.
Jiang C, Yuan B, Hang B, Mao JH, Zou X, Wang P. Jiang C, et al. Oncol Lett. 2021 Oct;22(4):712. doi: 10.3892/ol.2021.12973. Epub 2021 Aug 5. Oncol Lett. 2021. PMID: 34457067 Free PMC article.
Gastric cancer (GC) is one of the main causes of cancer-associated morbidity and mortality worldwide. The present study aimed to investigate the role of the gene encoding formin homology 2 domain containing 1 (FHOD1) protein in GC development. Data from The …
Gastric cancer (GC) is one of the main causes of cancer-associated morbidity and mortality worldwide. The present study aimed …
FHOD1 and FMNL1 formin proteins in intestinal gastric cancer: correlation with tumor-infiltrating T lymphocytes and molecular subtypes.
Mansuri N, Heuser VD, Birkman EM, Lintunen M, Ålgars A, Sundström J, Ristamäki R, Carpén O, Lehtinen L. Mansuri N, et al. Gastric Cancer. 2021 Nov;24(6):1254-1263. doi: 10.1007/s10120-021-01203-7. Epub 2021 Jun 11. Gastric Cancer. 2021. PMID: 34115237 Free PMC article.
BACKGROUND: Gastric cancer (GC) is the third most common cause of cancer death. Intestinal type GC is a molecularly diverse disease. ...FHOD1 correlates with high intratumoral CD8 + T lymphocyte infiltration in this cohort....
BACKGROUND: Gastric cancer (GC) is the third most common cause of cancer death. Intestinal type GC is a molecularly diverse di …
Characterization of Expression and Function of the Formins FHOD1, INF2, and DAAM1 in HER2-Positive Breast Cancer.
Peippo M, Gardberg M, Kronqvist P, Carpén O, Heuser VD. Peippo M, et al. J Breast Cancer. 2023 Dec;26(6):525-543. doi: 10.4048/jbc.2023.26.e47. Epub 2023 Nov 17. J Breast Cancer. 2023. PMID: 37985384 Free PMC article.
RESULTS: Our results revealed that correlations between INF2, FHOD1, and DAAM1 mRNA expression and ERBB2 in HER2-subtype breast cancer were associated with worse outcomes. ...Notably, siRNA-mediated knockdown of HER2 affected FHOD1 and INF2 expression, along …
RESULTS: Our results revealed that correlations between INF2, FHOD1, and DAAM1 mRNA expression and ERBB2 in HER2-subtype breast ca …
FHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasion.
Gardberg M, Kaipio K, Lehtinen L, Mikkonen P, Heuser VD, Talvinen K, Iljin K, Kampf C, Uhlen M, Grénman R, Koivisto M, Carpén O. Gardberg M, et al. PLoS One. 2013 Sep 26;8(9):e74923. doi: 10.1371/journal.pone.0074923. eCollection 2013. PLoS One. 2013. PMID: 24086398 Free PMC article.
Furthermore, functional assays demonstrated that FHOD1 contributes to cell migration and invasion. Finally, FHOD1 depletion reduced the ability of EMT cancer cells to form invadopodia and to degrade extracellular matrix. Our results indicate that FHOD1 …
Furthermore, functional assays demonstrated that FHOD1 contributes to cell migration and invasion. Finally, FHOD1 depletion re …
Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.
Heuser VD, Mansuri N, Mogg J, Kurki S, Repo H, Kronqvist P, Carpén O, Gardberg M. Heuser VD, et al. Breast Cancer (Auckl). 2018 Aug 24;12:1178223418792247. doi: 10.1177/1178223418792247. eCollection 2018. Breast Cancer (Auckl). 2018. PMID: 30158824 Free PMC article.
The actin-regulating formin protein FHOD1 participates in invasion of the triple-negative breast cancer cell line MDA-MB-231. ...We report that basal-like breast cancers frequently overexpress formin proteins FHOD1 and INF2. In cell studies using basal …
The actin-regulating formin protein FHOD1 participates in invasion of the triple-negative breast cancer cell line MDA-MB-231. …
FHOD1 is upregulated in glioma cells and attenuates ferroptosis of glioma cells by targeting HSPB1 signaling.
Zhang F, Wu L, Feng S, Zhao Z, Zhang K, Thakur A, Xu Z, Liang Q, Liu Y, Liu W, Yan Y. Zhang F, et al. CNS Neurosci Ther. 2023 Nov;29(11):3351-3363. doi: 10.1111/cns.14264. Epub 2023 May 21. CNS Neurosci Ther. 2023. PMID: 37211949 Free PMC article.
We also explored the regulatory roles of abnormally expressed formin homology 2 domain-containing protein 1 (FHOD1) in glioma ferroptosis sensitivity. RESULTS: In our study, FHOD1 was identified to be the most significantly upregulated protein in glioma tissues. ... …
We also explored the regulatory roles of abnormally expressed formin homology 2 domain-containing protein 1 (FHOD1) in glioma ferropt …
MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F.
Jurmeister S, Baumann M, Balwierz A, Keklikoglou I, Ward A, Uhlmann S, Zhang JD, Wiemann S, Sahin Ö. Jurmeister S, et al. Mol Cell Biol. 2012 Feb;32(3):633-51. doi: 10.1128/MCB.06212-11. Epub 2011 Dec 5. Mol Cell Biol. 2012. PMID: 22144583 Free PMC article.
We identified FHOD1 and PPM1F, direct regulators of the actin cytoskeleton, as novel targets of miR-200c. Remarkably, expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines, breast cancer p …
We identified FHOD1 and PPM1F, direct regulators of the actin cytoskeleton, as novel targets of miR-200c. Remarkably, expression leve …
FHOD1 formin is upregulated in melanomas and modifies proliferation and tumor growth.
Peippo M, Gardberg M, Lamminen T, Kaipio K, Carpén O, Heuser VD. Peippo M, et al. Exp Cell Res. 2017 Jan 1;350(1):267-278. doi: 10.1016/j.yexcr.2016.12.004. Epub 2016 Dec 2. Exp Cell Res. 2017. PMID: 27919746 Free article.
FHOD1 participates in cancer-associated epithelial to mesenchymal transition (EMT) in oral squamous cell carcinoma and breast cancer. ...By using shRNA to knockdown FHOD1 in melanoma cells, we discovered that FHOD1 depleted cells are larger, rou …
FHOD1 participates in cancer-associated epithelial to mesenchymal transition (EMT) in oral squamous cell carcinoma and breast …
FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers.
Schulze N, Graessl M, Blancke Soares A, Geyer M, Dehmelt L, Nalbant P. Schulze N, et al. J Cell Sci. 2014 Apr 1;127(Pt 7):1379-93. doi: 10.1242/jcs.134627. Epub 2014 Jan 30. J Cell Sci. 2014. PMID: 24481812
The formin FHOD1 (formin homology 2 domain containing protein 1) can act as a capping and bundling protein in vitro. In cells, active FHOD1 stimulates the formation of ventral stress fibers. However, the cellular mechanisms by which this phenotype is produced and th …
The formin FHOD1 (formin homology 2 domain containing protein 1) can act as a capping and bundling protein in vitro. In cells, active …
Role of FHOD1 in tumor cells and tumor immune microenvironment.
Yang Y, Kang Z, Cai J, Jia S, Fan S, Zhu H. Yang Y, et al. Front Immunol. 2025 Apr 29;16:1514488. doi: 10.3389/fimmu.2025.1514488. eCollection 2025. Front Immunol. 2025. PMID: 40364836 Free PMC article. Review.
Aberrant expression and dysfunction of the FHOD1 protein play a key role in tumor immunosuppression. Specifically, FHOD1 can impair function of chemokine receptors that are supposed to direct immune cells to localize to the tumor site accurately. ...Altogether this …
Aberrant expression and dysfunction of the FHOD1 protein play a key role in tumor immunosuppression. Specifically, FHOD1 can i …
31 results