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FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP.
Tsuchiya Y, Nakabayashi O, Nakano H. Tsuchiya Y, et al. Int J Mol Sci. 2015 Dec 18;16(12):30321-41. doi: 10.3390/ijms161226232. Int J Mol Sci. 2015. PMID: 26694384 Free PMC article. Review.
Moreover, recent studies have revealed that cFLIP is also involved in a non-apoptotic cell death pathway known as programmed necrosis or necroptosis. These functions of cFLIP are strictly controlled in an isoform-, concentration- and tissue-specific manner, and the ubiquit …
Moreover, recent studies have revealed that cFLIP is also involved in a non-apoptotic cell death pathway known as programmed necrosis or …
Roles of c-FLIP in Apoptosis, Necroptosis, and Autophagy.
Safa AR. Safa AR. J Carcinog Mutagen. 2013;Suppl 6:003. doi: 10.4172/2157-2518.S6-003. J Carcinog Mutagen. 2013. PMID: 25379355 Free PMC article.
Necroptosis is regulated by the Ripoptosome, which is a signaling intracellular cell death platform complex. The Ripoptosome contains receptor-interacting protein-1/Receptor-Interacting Protein-3 (RIP1), caspase-8, caspase-10, FADD, and c-FLIP isoforms involv
Necroptosis is regulated by the Ripoptosome, which is a signaling intracellular cell death platform complex. The Ripoptosome c