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Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance.
Domanskyi A, Alter H, Vogt MA, Gass P, Vinnikov IA. Domanskyi A, et al. Front Cell Neurosci. 2014 Sep 9;8:275. doi: 10.3389/fncel.2014.00275. eCollection 2014. Front Cell Neurosci. 2014. PMID: 25249938 Free PMC article.
The proteins Foxa1 and Foxa2 belong to the forkhead family of transcription factors and are involved in the development of several tissues, including liver, pancreas, lung, prostate, and the neural system. ...Altogether, in this study, we address the molecular, cell …
The proteins Foxa1 and Foxa2 belong to the forkhead family of transcription factors and are involved in the development of several ti …
Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues.
Besnard V, Wert SE, Hull WM, Whitsett JA. Besnard V, et al. Gene Expr Patterns. 2004 Dec;5(2):193-208. doi: 10.1016/j.modgep.2004.08.006. Gene Expr Patterns. 2004. PMID: 15567715
In the present study, we have generated highly specific antibodies for Foxa1 and Foxa2 and determined their expression patterns in the developing and adult mouse. Foxa1 and Foxa2 were detected in the nuclei of tissues derived from both foregut and hindgut end …
In the present study, we have generated highly specific antibodies for Foxa1 and Foxa2 and determined their expression patterns in th …
Liver-enriched transcription factors and hepatocyte differentiation.
Cereghini S. Cereghini S. FASEB J. 1996 Feb;10(2):267-82. FASEB J. 1996. PMID: 8641560 Review.
Liver-specific gene expression in adult hepatocytes relies on four families of evolutionary conserved transcription factors that are liver-enriched but not restricted to this tissue. ...The consequences of inactivating different family members in the mouse by …
Liver-specific gene expression in adult hepatocytes relies on four families of evolutionary conserved transcription factors th …
Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers.
Mordaunt CE, Kieffer DA, Shibata NM, Członkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Mordaunt CE, et al. Epigenetics Chromatin. 2019 Feb 1;12(1):10. doi: 10.1186/s13072-019-0255-z. Epigenetics Chromatin. 2019. PMID: 30709419 Free PMC article.
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active liver promoters, and binding sites of liver developmental transcription factors, including Hepatocyte Nuclear Factor 4 alpha (H …
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active …
Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation.
Spear BT, Jin L, Ramasamy S, Dobierzewska A. Spear BT, et al. Cell Mol Life Sci. 2006 Dec;63(24):2922-38. doi: 10.1007/s00018-006-6258-5. Cell Mol Life Sci. 2006. PMID: 17041810 Free PMC article. Review.
Several recent gene-knockout studies in mice have clarified the roles of GATA6, HNF4alpha, and Foxa1/Foxa2 in early stages of liver formation. After the liver forms, transcriptional changes continue to occur; during the perinatal period, certain genes such as …
Several recent gene-knockout studies in mice have clarified the roles of GATA6, HNF4alpha, and Foxa1/Foxa2 in early stages of live …
FOXA2 alleviates CCl(4)-induced liver fibrosis by protecting hepatocytes in mice.
Wang W, Yao LJ, Shen W, Ding K, Shi PM, Chen F, He J, Ding J, Zhang X, Xie WF. Wang W, et al. Sci Rep. 2017 Nov 14;7(1):15532. doi: 10.1038/s41598-017-15831-6. Sci Rep. 2017. PMID: 29138513 Free PMC article.
However, the role of FOXA2 in liver fibrogenesis remains undefined. In this study, we found that the abundance of FOXA2 was significantly lower in fibrotic livers of patients and mice treated with CCl(4) than in controls. ...Hepatocyte-specific ablatio …
However, the role of FOXA2 in liver fibrogenesis remains undefined. In this study, we found that the abundance of FOXA2 …
Triple Staining Including FOXA2 Identifies Stem Cell Lineages Undergoing Hepatic and Biliary Differentiation in Cirrhotic Human Liver.
Rogler CE, Bebawee R, Matarlo J, Locker J, Pattamanuch N, Gupta S, Rogler LE. Rogler CE, et al. J Histochem Cytochem. 2017 Jan;65(1):33-46. doi: 10.1369/0022155416675153. Epub 2016 Nov 24. J Histochem Cytochem. 2017. PMID: 27879410 Free PMC article.
Recent investigations have reported many markers associated with human liver stem/progenitor cells, "oval cells," and identified "niches" in diseased livers where stem cells occur. ...We identified large clusters of disorganized, FOXA2 expressing, oval cells …
Recent investigations have reported many markers associated with human liver stem/progenitor cells, "oval cells," and identified "nic …
Exploring the genomic and transcriptomic profiles of glycemic traits and drug repurposing.
Lin MR, Tsai CL, Liao CS, Wei CY, Chou WH, Hsiao TH, Chang WC. Lin MR, et al. J Biomed Sci. 2025 May 21;32(1):50. doi: 10.1186/s12929-025-01137-7. J Biomed Sci. 2025. PMID: 40399988 Free PMC article.
RESULTS: This study assessed hemoglobin A1c and fasting glucose levels, validating known loci (FN3K, SPC25, MTNR1B, and FOXA2) and discovering new genes, including MAEA and PRC1. Additionally, we found that diabetes, blood lipids, and liver- and kidney-related trait …
RESULTS: This study assessed hemoglobin A1c and fasting glucose levels, validating known loci (FN3K, SPC25, MTNR1B, and FOXA2) and di …
Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing.
Wederell ED, Bilenky M, Cullum R, Thiessen N, Dagpinar M, Delaney A, Varhol R, Zhao Y, Zeng T, Bernier B, Ingham M, Hirst M, Robertson G, Marra MA, Jones S, Hoodless PA. Wederell ED, et al. Nucleic Acids Res. 2008 Aug;36(14):4549-64. doi: 10.1093/nar/gkn382. Epub 2008 Jul 8. Nucleic Acids Res. 2008. PMID: 18611952 Free PMC article.
QPCR analysis demonstrated a strong positive correlation between peak height and fold enrichment for Foxa2-binding sites. We measured the relationship between Foxa2 and liver gene expression by overlapping Foxa2-binding sites with a SAGE transcriptome …
QPCR analysis demonstrated a strong positive correlation between peak height and fold enrichment for Foxa2-binding sites. We measured …
Foxa1 and Foxa2 regulate bile duct development in mice.
Li Z, White P, Tuteja G, Rubins N, Sackett S, Kaestner KH. Li Z, et al. J Clin Invest. 2009 Jun;119(6):1537-45. doi: 10.1172/JCI38201. Epub 2009 May 11. J Clin Invest. 2009. PMID: 19436110 Free PMC article.
Using conditional gene ablation during a later phase of liver development, we show here that deletion of both Foxa1 and Foxa2 (Foxa1/2) in the embryonic liver caused hyperplasia of the biliary tree. ...Our data suggest that Foxa1/2 function as terminators of …
Using conditional gene ablation during a later phase of liver development, we show here that deletion of both Foxa1 and Foxa2 …
84 results