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Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance.
Domanskyi A, Alter H, Vogt MA, Gass P, Vinnikov IA. Domanskyi A, et al. Front Cell Neurosci. 2014 Sep 9;8:275. doi: 10.3389/fncel.2014.00275. eCollection 2014. Front Cell Neurosci. 2014. PMID: 25249938 Free PMC article.
The proteins Foxa1 and Foxa2 belong to the forkhead family of transcription factors and are involved in the development of several tissues, including liver, pancreas, lung, prostate, and the neural system. ...Notably, both Foxa1 and Foxa2 factors continue to …
The proteins Foxa1 and Foxa2 belong to the forkhead family of transcription factors and are involved in the development of several ti …
Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues.
Besnard V, Wert SE, Hull WM, Whitsett JA. Besnard V, et al. Gene Expr Patterns. 2004 Dec;5(2):193-208. doi: 10.1016/j.modgep.2004.08.006. Gene Expr Patterns. 2004. PMID: 15567715
In the present study, we have generated highly specific antibodies for Foxa1 and Foxa2 and determined their expression patterns in the developing and adult mouse. ...Colocalization and distinct sites of expression of Foxa1 and Foxa2 indicate unique as well as …
In the present study, we have generated highly specific antibodies for Foxa1 and Foxa2 and determined their expression patterns in th …
Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers.
Mordaunt CE, Kieffer DA, Shibata NM, Członkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Mordaunt CE, et al. Epigenetics Chromatin. 2019 Feb 1;12(1):10. doi: 10.1186/s13072-019-0255-z. Epigenetics Chromatin. 2019. PMID: 30709419 Free PMC article.
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active liver promoters, and binding sites of liver developmental transcription factors, including Hepatocyte Nuclear Factor 4 alpha (H …
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active …
FOXA2 alleviates CCl(4)-induced liver fibrosis by protecting hepatocytes in mice.
Wang W, Yao LJ, Shen W, Ding K, Shi PM, Chen F, He J, Ding J, Zhang X, Xie WF. Wang W, et al. Sci Rep. 2017 Nov 14;7(1):15532. doi: 10.1038/s41598-017-15831-6. Sci Rep. 2017. PMID: 29138513 Free PMC article.
However, the role of FOXA2 in liver fibrogenesis remains undefined. In this study, we found that the abundance of FOXA2 was significantly lower in fibrotic livers of patients and mice treated with CCl(4) than in controls. ...Hepatocyte-specific ablatio …
However, the role of FOXA2 in liver fibrogenesis remains undefined. In this study, we found that the abundance of FOXA2
Triple Staining Including FOXA2 Identifies Stem Cell Lineages Undergoing Hepatic and Biliary Differentiation in Cirrhotic Human Liver.
Rogler CE, Bebawee R, Matarlo J, Locker J, Pattamanuch N, Gupta S, Rogler LE. Rogler CE, et al. J Histochem Cytochem. 2017 Jan;65(1):33-46. doi: 10.1369/0022155416675153. Epub 2016 Nov 24. J Histochem Cytochem. 2017. PMID: 27879410 Free PMC article.
Recent investigations have reported many markers associated with human liver stem/progenitor cells, "oval cells," and identified "niches" in diseased livers where stem cells occur. ...We identified large clusters of disorganized, FOXA2 expressing, oval cells …
Recent investigations have reported many markers associated with human liver stem/progenitor cells, "oval cells," and identified "nic …
Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation.
Spear BT, Jin L, Ramasamy S, Dobierzewska A. Spear BT, et al. Cell Mol Life Sci. 2006 Dec;63(24):2922-38. doi: 10.1007/s00018-006-6258-5. Cell Mol Life Sci. 2006. PMID: 17041810 Review.
Numerous genes must be properly regulated for the liver to develop and perform a variety of activities. Several recent gene-knockout studies in mice have clarified the roles of GATA6, HNF4alpha, and Foxa1/Foxa2 in early stages of liver formation. ...Finally, …
Numerous genes must be properly regulated for the liver to develop and perform a variety of activities. Several recent gene-knockout …
Novel FOXA2 mutation causes Hyperinsulinism, Hypopituitarism with Craniofacial and Endoderm-derived organ abnormalities.
Giri D, Vignola ML, Gualtieri A, Scagliotti V, McNamara P, Peak M, Didi M, Gaston-Massuet C, Senniappan S. Giri D, et al. Hum Mol Genet. 2017 Nov 15;26(22):4315-4326. doi: 10.1093/hmg/ddx318. Hum Mol Genet. 2017. PMID: 28973288
In this study, we identified a de novo heterozygous mutation in the developmental transcription factor, forkhead box A2, FOXA2 (c.505T>C, p.S169P) in a child with CHI and CH with craniofacial dysmorphic features, choroidal coloboma and endoderm-derived organ malformatio …
In this study, we identified a de novo heterozygous mutation in the developmental transcription factor, forkhead box A2, FOXA2 (c.505 …
Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing.
Wederell ED, Bilenky M, Cullum R, Thiessen N, Dagpinar M, Delaney A, Varhol R, Zhao Y, Zeng T, Bernier B, Ingham M, Hirst M, Robertson G, Marra MA, Jones S, Hoodless PA. Wederell ED, et al. Nucleic Acids Res. 2008 Aug;36(14):4549-64. doi: 10.1093/nar/gkn382. Epub 2008 Jul 8. Nucleic Acids Res. 2008. PMID: 18611952 Free PMC article.
QPCR analysis demonstrated a strong positive correlation between peak height and fold enrichment for Foxa2-binding sites. We measured the relationship between Foxa2 and liver gene expression by overlapping Foxa2-binding sites with a SAGE transcriptome …
QPCR analysis demonstrated a strong positive correlation between peak height and fold enrichment for Foxa2-binding sites. We measured …
Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.
Hoffman BG, Robertson G, Zavaglia B, Beach M, Cullum R, Lee S, Soukhatcheva G, Li L, Wederell ED, Thiessen N, Bilenky M, Cezard T, Tam A, Kamoh B, Birol I, Dai D, Zhao Y, Hirst M, Verchere CB, Helgason CD, Marra MA, Jones SJ, Hoodless PA. Hoffman BG, et al. Genome Res. 2010 Aug;20(8):1037-51. doi: 10.1101/gr.104356.109. Epub 2010 Jun 15. Genome Res. 2010. PMID: 20551221 Free PMC article.
To gain insight into the transcriptional networks regulating the function of these tissues, we globally identify binding sites for FOXA2 in adult mouse islets and liver, PDX1 in islets, and HNF4A in liver. ...Finally, we apply these approaches to gener …
To gain insight into the transcriptional networks regulating the function of these tissues, we globally identify binding sites for FOXA2
Overexpression of transcription factor Foxa2 and Hnf1alpha induced rat bone mesenchymal stem cells into hepatocytes.
Ding Y, Chang C, Niu Z, Dai K, Geng X, Li D, Guo J, Xu C. Ding Y, et al. Cytotechnology. 2016 Oct;68(5):2037-47. doi: 10.1007/s10616-016-9944-7. Epub 2016 Jan 21. Cytotechnology. 2016. PMID: 26797779 Free PMC article.
Hepatocytes differentiated from induced pluripotent stem cells and adult stem cells could be utilized as a tool for the study of liver diseases, screening for drug metabolism and hepatotoxicity. ...Three weeks after the induction, the expressions of FOXA2 and …
Hepatocytes differentiated from induced pluripotent stem cells and adult stem cells could be utilized as a tool for the study of l
82 results