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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
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1997 1
1998 1
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2001 4
2003 2
2004 4
2005 3
2006 2
2007 1
2008 4
2009 3
2010 5
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2012 5
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2015 3
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2017 5
2018 3
2019 3
2020 1
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Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers.
Mordaunt CE, Kieffer DA, Shibata NM, Członkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Mordaunt CE, et al. Epigenetics Chromatin. 2019 Feb 1;12(1):10. doi: 10.1186/s13072-019-0255-z. Epigenetics Chromatin. 2019. PMID: 30709419 Free PMC article.
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active liver promoters, and binding sites of liver developmental transcription factors, including Hepatocyte Nuclear Factor 4 alpha (H …
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active …
Bile acid-induced apoptosis and bile acid synthesis are reduced by over-expression of Augmenter of Liver Regeneration (ALR) in a STAT3-dependent mechanism.
Ibrahim S, Dayoub R, Krautbauer S, Liebisch G, Wege AK, Melter M, Weiss TS. Ibrahim S, et al. Exp Cell Res. 2019 Jan 1;374(1):189-197. doi: 10.1016/j.yexcr.2018.11.023. Epub 2018 Nov 28. Exp Cell Res. 2019. PMID: 30500391
Cholestasis represents pathophysiologic syndromes defined as an impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocytes injury followed by liver cirrhosis and liver failure. ...We found decreased hepatic mRNA levels of …
Cholestasis represents pathophysiologic syndromes defined as an impaired bile flow from the liver. As an outcome, bile acids accumula …
FOXA2 alleviates CCl(4)-induced liver fibrosis by protecting hepatocytes in mice.
Wang W, Yao LJ, Shen W, Ding K, Shi PM, Chen F, He J, Ding J, Zhang X, Xie WF. Wang W, et al. Sci Rep. 2017 Nov 14;7(1):15532. doi: 10.1038/s41598-017-15831-6. Sci Rep. 2017. PMID: 29138513 Free PMC article.
However, the role of FOXA2 in liver fibrogenesis remains undefined. In this study, we found that the abundance of FOXA2 was significantly lower in fibrotic livers of patients and mice treated with CCl(4) than in controls. ...Hepatocyte-specific ablatio …
However, the role of FOXA2 in liver fibrogenesis remains undefined. In this study, we found that the abundance of FOXA2
Overexpression of transcription factor Foxa2 and Hnf1α induced rat bone mesenchymal stem cells into hepatocytes.
Ding Y, Chang C, Niu Z, Dai K, Geng X, Li D, Guo J, Xu C. Ding Y, et al. Cytotechnology. 2016 Oct;68(5):2037-47. doi: 10.1007/s10616-016-9944-7. Epub 2016 Jan 21. Cytotechnology. 2016. PMID: 26797779 Free PMC article.
Hepatocytes differentiated from induced pluripotent stem cells and adult stem cells could be utilized as a tool for the study of liver diseases, screening for drug metabolism and hepatotoxicity. ...Three weeks after the induction, the expressions of FOXA2 and …
Hepatocytes differentiated from induced pluripotent stem cells and adult stem cells could be utilized as a tool for the study of l
Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway.
Shen J, Zhou Y, Zhang X, Peng W, Peng C, Zhou Q, Li C, Wen T, Shi Y. Shen J, et al. Aging (Albany NY). 2019 Nov 5;11(21):9280-9294. doi: 10.18632/aging.102332. Epub 2019 Nov 5. Aging (Albany NY). 2019. PMID: 31689237 Free PMC article.
FOXA2 is an archetypal transcription factor involved in cholangiocyte proliferation. RESULTS: FOXA2 expression was negatively correlated with tumor stage (p = 0.024). ...CONCLUSION: Low FOXA2 expression negatively affected the prognosis of patients with ICC.
FOXA2 is an archetypal transcription factor involved in cholangiocyte proliferation. RESULTS: FOXA2 expression was negatively
Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP).
Huff M, da Silveira WA, Carnevali O, Renaud L, Hardiman G. Huff M, et al. Sci Rep. 2018 Feb 1;8(1):2118. doi: 10.1038/s41598-018-20266-8. Sci Rep. 2018. PMID: 29391432 Free PMC article.
This study examined the adult male zebrafish (Danio rerio) transcriptome after exposure to environmental levels of DEHP and 17α-ethinylestradiol (EE2) using both DNA microarray and RNA-sequencing technologies. Our results show that exposure to DEHP is associated with diffe …
This study examined the adult male zebrafish (Danio rerio) transcriptome after exposure to environmental levels of DEHP and 17α-ethin …
Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance.
Domanskyi A, Alter H, Vogt MA, Gass P, Vinnikov IA. Domanskyi A, et al. Front Cell Neurosci. 2014 Sep 9;8:275. doi: 10.3389/fncel.2014.00275. eCollection 2014. Front Cell Neurosci. 2014. PMID: 25249938 Free PMC article.
The proteins Foxa1 and Foxa2 belong to the forkhead family of transcription factors and are involved in the development of several tissues, including liver, pancreas, lung, prostate, and the neural system. Both Foxa1 and Foxa2 are also crucial for the specifi …
The proteins Foxa1 and Foxa2 belong to the forkhead family of transcription factors and are involved in the development of several ti …
Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues.
Besnard V, Wert SE, Hull WM, Whitsett JA. Besnard V, et al. Gene Expr Patterns. 2004 Dec;5(2):193-208. doi: 10.1016/j.modgep.2004.08.006. Gene Expr Patterns. 2004. PMID: 15567715
In the present study, we have generated highly specific antibodies for Foxa1 and Foxa2 and determined their expression patterns in the developing and adult mouse. ...Colocalization and distinct sites of expression of Foxa1 and Foxa2 indicate unique as well as …
In the present study, we have generated highly specific antibodies for Foxa1 and Foxa2 and determined their expression patterns in th …
Tumor-promoting cyanotoxin microcystin-LR does not induce procarcinogenic events in adult human liver stem cells.
Raska J, Ctverackova L, Dydowiczova A, Sovadinova I, Blaha L, Babica P. Raska J, et al. Toxicol Appl Pharmacol. 2018 Apr 15;345:103-113. doi: 10.1016/j.taap.2018.03.011. Epub 2018 Mar 10. Toxicol Appl Pharmacol. 2018. PMID: 29534881
HL1-hT1 cell line represents adult human liver stem cells (LSCs) immortalized with human telomerase reverse transcriptase. In this study, HL1-hT1 cells were found to express mesenchymal markers (vimentin, CD73, CD90/THY-1 and CD105) and an early hepatic endoderm mar …
HL1-hT1 cell line represents adult human liver stem cells (LSCs) immortalized with human telomerase reverse transcriptase. In …
Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.
Hoffman BG, Robertson G, Zavaglia B, Beach M, Cullum R, Lee S, Soukhatcheva G, Li L, Wederell ED, Thiessen N, Bilenky M, Cezard T, Tam A, Kamoh B, Birol I, Dai D, Zhao Y, Hirst M, Verchere CB, Helgason CD, Marra MA, Jones SJ, Hoodless PA. Hoffman BG, et al. Genome Res. 2010 Aug;20(8):1037-51. doi: 10.1101/gr.104356.109. Epub 2010 Jun 15. Genome Res. 2010. PMID: 20551221 Free PMC article.
The liver and pancreas share a common origin and coexpress several transcription factors. To gain insight into the transcriptional networks regulating the function of these tissues, we globally identify binding sites for FOXA2 in adult mouse islets and liv
The liver and pancreas share a common origin and coexpress several transcription factors. To gain insight into the transcriptional ne …
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