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Page 1
FOXP1 Syndrome.
Rappold G, Siper P, Kostic A, Braden R, Morgan A, Koene S, Kolevzon A. Rappold G, et al. 2023 Sep 21. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 2023 Sep 21. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. PMID: 37733892 Free Books & Documents. Review.
Rarely, a parent of an individual with FOXP1 syndrome has somatic and germline mosaicism for the FOXP1 pathogenic variant or a complex chromosome arrangement involving FOXP1. Each child of an individual with FOXP1 syndrome has a 50% chance of inheritin …
Rarely, a parent of an individual with FOXP1 syndrome has somatic and germline mosaicism for the FOXP1 pathogenic variant or a …
Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1.
Wu M, Tang W, Chen Y, Xue L, Dai J, Li Y, Zhu X, Wu C, Xiong J, Zhang J, Wu T, Zhou S, Chen D, Sun C, Yu J, Li H, Guo Y, Huang Y, Zhu Q, Wei S, Zhou Z, Wu M, Li Y, Xiang T, Qiao H, Wang S. Wu M, et al. Nat Aging. 2024 Apr;4(4):527-545. doi: 10.1038/s43587-024-00607-1. Epub 2024 Apr 9. Nat Aging. 2024. PMID: 38594460 Free PMC article.
Three granulosa cells subtypes and five theca and stromal cells subtypes, as well as their spatiotemporal transcriptomics changes during aging, are identified. FOXP1 emerges as a regulator of ovarian aging, declining with age and inhibiting CDKN1A transcription. Silencing …
Three granulosa cells subtypes and five theca and stromal cells subtypes, as well as their spatiotemporal transcriptomics changes during agi …
NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer.
Chen X, Hao Y, Liu Y, Zhong S, You Y, Ao K, Chong T, Luo X, Yin M, Ye M, He H, Lu A, Chen J, Li X, Zhang J, Guo X. Chen X, et al. Adv Sci (Weinh). 2023 Nov;10(32):e2302705. doi: 10.1002/advs.202302705. Epub 2023 Oct 11. Adv Sci (Weinh). 2023. PMID: 37818745 Free PMC article.
Subsequently, it is found that HOXC8 activated NAT10 by binding to its promoter, thereby stimulating ac4C modification of FOXP1 mRNA and enhancing its translation efficiency, eventually leading to induction of GLUT4 and KHK expression. Moreover, NAT10/ac4C/FOXP1 axi …
Subsequently, it is found that HOXC8 activated NAT10 by binding to its promoter, thereby stimulating ac4C modification of FOXP1 mRNA …
Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia.
Ducharme JB, Neyroud D, Schonk MM, Gutierrez-Monreal MA, Huo Z, Tucker HO, Esser KA, Judge SM, Judge AR. Ducharme JB, et al. Cell Rep. 2025 May 27;44(5):115689. doi: 10.1016/j.celrep.2025.115689. Epub 2025 May 10. Cell Rep. 2025. PMID: 40349340 Free PMC article.
We previously found that forkhead box P1 (FoxP1) upregulation in skeletal muscle causes muscle wasting and is required for muscle wasting in response to cancer. However, transcriptional networks targeted by FoxP1 in skeletal muscles undergoing cancer-induced wasting …
We previously found that forkhead box P1 (FoxP1) upregulation in skeletal muscle causes muscle wasting and is required for muscle was …
Cardiomyocyte Foxp1-Specific Deletion Promotes Post-injury Heart Regeneration via Targeting Usp20-HIF1 -Hand1 Signaling Pathway.
Wang Y, Wang X, Fang J, Chen X, Xu T, Zhuang T, Peng S, Bao W, Wu W, Lu Y, Wang H, Tomlinson B, Chan P, Zhuang S, Zhang Q, Zhang L, Liu Z, Pi J, Zhang Y, Liu J. Wang Y, et al. Adv Sci (Weinh). 2025 Mar;12(12):e2412124. doi: 10.1002/advs.202412124. Epub 2025 Feb 3. Adv Sci (Weinh). 2025. PMID: 39899693 Free PMC article.
The adult mammalian heart has limited regenerative capacity to replace lost tissue after a major injury. Forkhead box P1 (Foxp1) regulates embryonic cardiomyocyte proliferation and heart development. However, whether Foxp1 participates in postnatal-injury cardiomyoc …
The adult mammalian heart has limited regenerative capacity to replace lost tissue after a major injury. Forkhead box P1 (Foxp1) regu …
Engineered Foxp1(high) Exosomes Ameliorates Systemic Lupus Erythematosus.
Niu L, Ou Q, Ren Q, Li Z, Chen H, Lei F, Mao X, Shi S, Chen Z, Teng W. Niu L, et al. Adv Sci (Weinh). 2025 Oct;12(37):e15712. doi: 10.1002/advs.202415712. Epub 2025 Jul 3. Adv Sci (Weinh). 2025. PMID: 40605719 Free PMC article.
First, MSCs produce a high yield of engineered exosomes through an aggregation culture engineering strategy (Agg-exo), demonstrating immune organ targeting and promoting Tregs via the Foxp1/STAT5/Foxp3 axis. Then, MSCs are engineered by overexpressing Foxp1 in order …
First, MSCs produce a high yield of engineered exosomes through an aggregation culture engineering strategy (Agg-exo), demonstrating immune …
Pyruvate dehydrogenase B regulates myogenic differentiation via the FoxP1-Arih2 axis.
Jiang X, Ji S, Yuan F, Li T, Cui S, Wang W, Ye X, Wang R, Chen Y, Zhu S. Jiang X, et al. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):606-621. doi: 10.1002/jcsm.13166. Epub 2022 Dec 23. J Cachexia Sarcopenia Muscle. 2023. PMID: 36564038 Free PMC article.

Metabolomic and transcriptomic analyses revealed that PDHB knockdown suppressed pyruvate metabolism (P < 0.001) and up-regulated ariadne RBR E3 ubiquitin protein ligase 2 (Arih2) (+7.23-fold, P < 0.001) in cellular catabolic pathways. The role of forkhead box P1 (FoxP1

…

Metabolomic and transcriptomic analyses revealed that PDHB knockdown suppressed pyruvate metabolism (P < 0.001) and up-regulated ariadne

…
FOXP1 syndrome: a review of the literature and practice parameters for medical assessment and monitoring.
Lozano R, Gbekie C, Siper PM, Srivastava S, Saland JM, Sethuram S, Tang L, Drapeau E, Frank Y, Buxbaum JD, Kolevzon A. Lozano R, et al. J Neurodev Disord. 2021 Apr 23;13(1):18. doi: 10.1186/s11689-021-09358-1. J Neurodev Disord. 2021. PMID: 33892622 Free PMC article. Review.
FOXP1 syndrome is a neurodevelopmental disorder caused by mutations or deletions that disrupt the forkhead box protein 1 (FOXP1) gene, which encodes a transcription factor important for the early development of many organ systems, including the brain. ...Here, we pr …
FOXP1 syndrome is a neurodevelopmental disorder caused by mutations or deletions that disrupt the forkhead box protein 1 (FOXP1 …
FBXO44 Regulates FOXP1 Degradation Through AURKA-Dependent Phosphorylation to Promote Colorectal Cancer Progression.
Nie H, Xu H, Yang S, Tian C, Wang T, Jin C, Chen Z, Wang X, Tang J, Feng Y, Sun Y. Nie H, et al. Adv Sci (Weinh). 2025 Dec;12(47):e15458. doi: 10.1002/advs.202415458. Epub 2025 Oct 6. Adv Sci (Weinh). 2025. PMID: 41051444 Free PMC article.
Mechanistically, FBXO44 targets Forkhead box protein P1 (FOXP1) for degradation. Aurora kinase A (AURKA) phosphorylates FOXP1 at Ser440, enhancing FBXO44 binding, leading to K48-linked ubiquitination at K377 and proteasomal degradation. This degradation relieves …
Mechanistically, FBXO44 targets Forkhead box protein P1 (FOXP1) for degradation. Aurora kinase A (AURKA) phosphorylates FOXP1 …
Foxp1 Is Required for Renal Intercalated Cell Differentiation and Acid-Base Regulation.
Wu ST, Feng Y, Song R, Qi Y, Li L, Lu D, Wang Y, Wu W, Morgan A, Wang X, Xia Y, Liu R, Alexander SI, Wong J, Zhang Y, Zheng X. Wu ST, et al. J Am Soc Nephrol. 2024 May 1;35(5):533-548. doi: 10.1681/ASN.0000000000000319. Epub 2024 Feb 9. J Am Soc Nephrol. 2024. PMID: 38332484 Free PMC article.
METHODS: To investigate the specific role of Foxp1 in kidney tubular system, we specifically deleted Foxp1 expression in kidney distal nephrons and collecting ducts. We examined the effects of Foxp1 on intercalated cell differentiation and urine acidification …
METHODS: To investigate the specific role of Foxp1 in kidney tubular system, we specifically deleted Foxp1 expression in kidne …
1,111 results