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2001 2
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823 results
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FOXP1 syndrome: a review of the literature and practice parameters for medical assessment and monitoring.
Lozano R, Gbekie C, Siper PM, Srivastava S, Saland JM, Sethuram S, Tang L, Drapeau E, Frank Y, Buxbaum JD, Kolevzon A. Lozano R, et al. J Neurodev Disord. 2021 Apr 23;13(1):18. doi: 10.1186/s11689-021-09358-1. J Neurodev Disord. 2021. PMID: 33892622 Free PMC article. Review.
FOXP1 syndrome is a neurodevelopmental disorder caused by mutations or deletions that disrupt the forkhead box protein 1 (FOXP1) gene, which encodes a transcription factor important for the early development of many organ systems, including the brain. ...Here, we pr
FOXP1 syndrome is a neurodevelopmental disorder caused by mutations or deletions that disrupt the forkhead box protein 1 (FOXP1
Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation.
Zhuang T, Liu J, Chen X, Zhang L, Pi J, Sun H, Li L, Bauer R, Wang H, Yu Z, Zhang Q, Tomlinson B, Chan P, Zheng X, Morrisey E, Liu Z, Reilly M, Zhang Y. Zhuang T, et al. Circ Res. 2019 Aug 30;125(6):590-605. doi: 10.1161/CIRCRESAHA.118.314402. Epub 2019 Jul 18. Circ Res. 2019. PMID: 31318658
Endothelial-specific Foxp1 knockout mice (Foxp1(ECKO)) were bred onto Apoe(KO) mice to generate endothelial Foxp1-deletion hyperlipidemic model Foxp1(ECKO);Apoe(KO), which displayed significant increases in atherosclerotic lesion formation in aortas an …
Endothelial-specific Foxp1 knockout mice (Foxp1(ECKO)) were bred onto Apoe(KO) mice to generate endothelial Foxp1-delet …
Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome.
Wang J, Fröhlich H, Torres FB, Silva RL, Poschet G, Agarwal A, Rappold GA. Wang J, et al. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2112852119. doi: 10.1073/pnas.2112852119. Proc Natl Acad Sci U S A. 2022. PMID: 35165191 Free PMC article.
FOXP1 syndrome caused by haploinsufficiency of the forkhead box protein P1 (FOXP1) gene is a neurodevelopmental disorder that manifests motor dysfunction, intellectual disability, autism, and language impairment. In this study, we used a Foxp1(+/-) mouse mode
FOXP1 syndrome caused by haploinsufficiency of the forkhead box protein P1 (FOXP1) gene is a neurodevelopmental disorder that
miR-29c-3p inhibits autophagy and cisplatin resistance in ovarian cancer by regulating FOXP1/ATG14 pathway.
Hu Z, Cai M, Zhang Y, Tao L, Guo R. Hu Z, et al. Cell Cycle. 2020 Jan;19(2):193-206. doi: 10.1080/15384101.2019.1704537. Epub 2019 Dec 29. Cell Cycle. 2020. PMID: 31885310 Free PMC article.
This study aims to identify the effect of miR-29c-3p/FOXP1/ATG14 pathway in regulating autophagy and DDP resistance in ovarian cancer. ...The anti-resistant effect of miR-29c-3p was observed as overexpressing miR-29c-3p inhibited cell viability of DDP-resistant cells. More …
This study aims to identify the effect of miR-29c-3p/FOXP1/ATG14 pathway in regulating autophagy and DDP resistance in ovarian cancer …
Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization.
Liu P, Huang S, Ling S, Xu S, Wang F, Zhang W, Zhou R, He L, Xia X, Yao Z, Fan Y, Wang N, Hu C, Zhao X, Tucker HO, Wang J, Guo X. Liu P, et al. Nat Commun. 2019 Nov 7;10(1):5070. doi: 10.1038/s41467-019-12988-8. Nat Commun. 2019. PMID: 31699980 Free PMC article.
Adipose-specific deletion of Foxp1 leads to an increase of brown adipose activity and browning program of white adipose tissues. ...Consistently, overexpression of Foxp1 in adipocytes impairs adaptive thermogenesis and promotes diet-induced obesity. ...
Adipose-specific deletion of Foxp1 leads to an increase of brown adipose activity and browning program of white adipose tissues. ...C …
FOXP1 drives osteosarcoma development by repressing P21 and RB transcription downstream of P53.
Li H, Han X, Yang S, Wang Y, Dong Y, Tang T. Li H, et al. Oncogene. 2021 Apr;40(15):2785-2802. doi: 10.1038/s41388-021-01742-4. Epub 2021 Mar 14. Oncogene. 2021. PMID: 33716296
Here, we determined the role and regulatory mechanisms of FOXP1 in osteosarcoma. Higher FOXP1 expression correlated with malignancy in both osteosarcoma cell lines and clinical biopsies. FOXP1 overexpression and knockdown in osteosarcoma cell lines revealed t …
Here, we determined the role and regulatory mechanisms of FOXP1 in osteosarcoma. Higher FOXP1 expression correlated with malig …
FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
Li H, Liu P, Xu S, Li Y, Dekker JD, Li B, Fan Y, Zhang Z, Hong Y, Yang G, Tang T, Ren Y, Tucker HO, Yao Z, Guo X. Li H, et al. J Clin Invest. 2017 Apr 3;127(4):1241-1253. doi: 10.1172/JCI89511. Epub 2017 Feb 27. J Clin Invest. 2017. PMID: 28240601 Free PMC article.
Loss of p16INK4A in Foxp1-deficient MSCs partially rescued the defects in replication capacity and bone mass accrual. Promoter occupancy analyses revealed that FOXP1 directly represses transcription of p16INK4A. These results indicate that FOXP1 attenuates MS …
Loss of p16INK4A in Foxp1-deficient MSCs partially rescued the defects in replication capacity and bone mass accrual. Promoter occupa …
FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness.
Neyroud D, Nosacka RL, Callaway CS, Trevino JG, Hu H, Judge SM, Judge AR. Neyroud D, et al. J Cachexia Sarcopenia Muscle. 2021 Apr;12(2):421-442. doi: 10.1002/jcsm.12666. Epub 2021 Feb 1. J Cachexia Sarcopenia Muscle. 2021. PMID: 33527776 Free PMC article.
METHODS: Inducible, skeletal muscle-specific FoxP1 over-expressing (FoxP1(iSkmTg/Tg) ) mice were generated through crossing conditional Foxp1a transgenic mice with HSA-MCM mice that express tamoxifen-inducible Cre recombinase under control of the skeletal muscle act …
METHODS: Inducible, skeletal muscle-specific FoxP1 over-expressing (FoxP1(iSkmTg/Tg) ) mice were generated through crossing co …
Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion.
Kaminskiy Y, Kuznetsova V, Kudriaeva A, Zmievskaya E, Bulatov E. Kaminskiy Y, et al. Front Immunol. 2022 Oct 4;13:971045. doi: 10.3389/fimmu.2022.971045. eCollection 2022. Front Immunol. 2022. PMID: 36268015 Free PMC article. Review.
Moreover, there is growing evidence that FOXP1 also regulates T-cell exhaustion. Altogether this makes FOXP1 a crucial and highly undervalued regulator of T-cell homeostasis. In this review, we discuss the biology of FOXP1 with a focus on discoveries made in …
Moreover, there is growing evidence that FOXP1 also regulates T-cell exhaustion. Altogether this makes FOXP1 a crucial and hig …
HMGB1/Foxp1 regulates hypoxia-induced inflammatory response in macrophages.
Hu J, Liu X, Tang Y. Hu J, et al. Cell Biol Int. 2022 Feb;46(2):265-277. doi: 10.1002/cbin.11728. Epub 2021 Dec 2. Cell Biol Int. 2022. PMID: 34816539
Forkhead box protein P1 (Foxp1) is a kind of tumor suppressor gene, and the role of Foxp1 in the macrophages of myocardial infarction (MI) has not been studied yet. ...As a transcription factor, HMGB1 regulated Foxp1 expression. The secretion of inflammatory …
Forkhead box protein P1 (Foxp1) is a kind of tumor suppressor gene, and the role of Foxp1 in the macrophages of myocardial inf …
823 results