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Page 1
Microglial TNFalpha controls daily changes in synaptic GABAARs and sleep slow waves.
Pinto MJ, Bizien L, Fabre JMJ, Ðukanović N, Lepetz V, Henderson F, Pujol M, Sala RW, Tarpin T, Popa D, Triller A, Léna C, Fabre V, Bessis A. Pinto MJ, et al. Among authors: fabre v. J Cell Biol. 2024 Jul 1;223(7):e202401041. doi: 10.1083/jcb.202401041. Epub 2024 May 2. J Cell Biol. 2024. PMID: 38695719 Free PMC article.
We reveal an activity-dependent regulation of cortical inhibitory synapses by microglia, driven by purinergic signaling acting on P2RX7 and mediated by microglia-derived TNFalpha. We demonstrate that sleep induces microglia-dependent synaptic enrichment of GABAARs in a man …
We reveal an activity-dependent regulation of cortical inhibitory synapses by microglia, driven by purinergic signaling acting on P2RX7 and …
Microglial TNFalpha orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep.
Pinto MJ, Cottin L, Dingli F, Laigle V, Ribeiro LF, Triller A, Henderson F, Loew D, Fabre V, Bessis A. Pinto MJ, et al. Among authors: fabre v. EMBO J. 2023 Jan 4;42(1):e111485. doi: 10.15252/embj.2022111485. Epub 2022 Nov 16. EMBO J. 2023. PMID: 36385434 Free PMC article.
Substrates of microglial TNFalpha comprise sleep-related kinases such as MAPKs and MARKs, and numerous synaptic proteins, including a subset whose phosphorylation status encodes sleep need and determines sleep duration. As a result, microglial TNFalpha loss a …
Substrates of microglial TNFalpha comprise sleep-related kinases such as MAPKs and MARKs, and numerous synaptic proteins, including a …
Regulation of stress-induced sleep perturbations by dorsal raphe VGLUT3 neurons in male mice.
Henderson F, Dumas S, Gangarossa G, Bernard V, Pujol M, Poirel O, Pietrancosta N, El Mestikawy S, Daumas S, Fabre V. Henderson F, et al. Among authors: fabre v. Cell Rep. 2024 Jul 23;43(7):114411. doi: 10.1016/j.celrep.2024.114411. Epub 2024 Jun 29. Cell Rep. 2024. PMID: 38944834 Free article.
We found that chemogenetic activation of DR(VGLUT3) neurons mimics stress-induced sleep perturbations. Furthermore, deleting VGLUT3 in the DR attenuated stress-induced sleep perturbations, especially after social defeat stress. ...However, deleting VGLUT3 in 5-HT ne …
We found that chemogenetic activation of DR(VGLUT3) neurons mimics stress-induced sleep perturbations. Furthermore, deleting VGLUT3 i …
Effects of Social Defeat Stress on Sleep in Mice.
Henderson F, Vialou V, El Mestikawy S, Fabre V. Henderson F, et al. Among authors: fabre v. Front Behav Neurosci. 2017 Nov 28;11:227. doi: 10.3389/fnbeh.2017.00227. eCollection 2017. Front Behav Neurosci. 2017. PMID: 29234278 Free PMC article.
Concomitantly, delta power was increased during non REM (NREM) sleep. During the following dark period, an increase in total sleep time, as well as wake fragmentation, were observed after each analyzed SD session. ...At R5, elevated high-frequency EEG activity, as o …
Concomitantly, delta power was increased during non REM (NREM) sleep. During the following dark period, an increase in total sleep …
Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons.
Bourgin P, Huitrón-Résendiz S, Spier AD, Fabre V, Morte B, Criado JR, Sutcliffe JG, Henriksen SJ, de Lecea L. Bourgin P, et al. Among authors: fabre v. J Neurosci. 2000 Oct 15;20(20):7760-5. doi: 10.1523/JNEUROSCI.20-20-07760.2000. J Neurosci. 2000. PMID: 11027239 Free PMC article.
The hypocretins/orexins have been implicated in the regulation of rapid eye movement (REM) sleep and the pathophysiology of narcolepsy. In the present study, we investigated whether the locus coeruleus (LC), a structure receiving dense hcrtergic innervation, which is quies …
The hypocretins/orexins have been implicated in the regulation of rapid eye movement (REM) sleep and the pathophysiology of narcoleps …
The GABAergic Gudden's dorsal tegmental nucleus: A new relay for serotonergic regulation of sleep-wake behavior in the mouse.
Chazalon M, Dumas S, Bernard JF, Sahly I, Tronche F, de Kerchove d'Exaerde A, Hamon M, Adrien J, Fabre V, Bonnavion P. Chazalon M, et al. Among authors: fabre v. Neuropharmacology. 2018 Aug;138:315-330. doi: 10.1016/j.neuropharm.2018.06.014. Epub 2018 Jun 14. Neuropharmacology. 2018. PMID: 29908240 Free article.
Serotonin (5-HT) neurons are involved in wake promotion and exert a strong inhibitory influence on rapid eye movement (REM) sleep. Such effects have been ascribed, at least in part to the action of 5-HT at post-synaptic 5-HT(1A) receptors (5-HT(1A)R) in the brainstem, a ma …
Serotonin (5-HT) neurons are involved in wake promotion and exert a strong inhibitory influence on rapid eye movement (REM) sleep. Su …
Cortistatin promotes and negatively correlates with slow-wave sleep.
Bourgin P, Fabre V, Huitrón-Reséndiz S, Henriksen SJ, Prospero-Garcia O, Criado JR, de Lecea L. Bourgin P, et al. Among authors: fabre v. Eur J Neurosci. 2007 Aug;26(3):729-38. doi: 10.1111/j.1460-9568.2007.05696.x. Eur J Neurosci. 2007. PMID: 17686045
Sleep need is characterized by the level of slow-wave activity (SWA) and increases with time spent awake. ...Steady-state levels of preprocortistatin mRNA oscillate during the light:dark cycle and are four-fold higher upon total 24-h sleep deprivation, returning pro …
Sleep need is characterized by the level of slow-wave activity (SWA) and increases with time spent awake. ...Steady-state levels of p …
Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors.
Popa D, Léna C, Fabre V, Prenat C, Gingrich J, Escourrou P, Hamon M, Adrien J. Popa D, et al. Among authors: fabre v. J Neurosci. 2005 Dec 7;25(49):11231-8. doi: 10.1523/JNEUROSCI.1724-05.2005. J Neurosci. 2005. PMID: 16339018 Free PMC article.
Serotonin (5-hydroxytryptamine; 5-HT) plays key roles in sleep-wakefulness regulation. Evidence indicates that 5-HT2 receptors are involved mainly in non-rapid eye movement sleep (NREMS) regulation and respiratory control. Here, we investigated the relative contribu …
Serotonin (5-hydroxytryptamine; 5-HT) plays key roles in sleep-wakefulness regulation. Evidence indicates that 5-HT2 receptors are in …
[Sleep and wakefulness regulation: molecular players].
Fabre V, Adrien J, Bonnavion P, Hamon M. Fabre V, et al. Bull Acad Natl Med. 2011 Oct;195(7):1551-65; discussion 1565. Bull Acad Natl Med. 2011. PMID: 22812160 French.
By combining brain section/lesion studies and sleep analysis, neurophysiologists have identified the brain areas responsible for regulating sleep and wakefulness during the first half of the 20th century. ...Hypocretin, also known as orexin, is a key neuropeptide in …
By combining brain section/lesion studies and sleep analysis, neurophysiologists have identified the brain areas responsible for regu …
Altered sleep homeostasis after restraint stress in 5-HTT knock-out male mice: a role for hypocretins.
Rachalski A, Alexandre C, Bernard JF, Saurini F, Lesch KP, Hamon M, Adrien J, Fabre V. Rachalski A, et al. Among authors: fabre v. J Neurosci. 2009 Dec 9;29(49):15575-85. doi: 10.1523/JNEUROSCI.3138-09.2009. J Neurosci. 2009. PMID: 20007481 Free PMC article.
Restraint stress produces changes in the sleep pattern that are mainly characterized by a delayed increase in rapid eye movement sleep (REMS) amounts. Because the serotonin (5-HT) and the hypocretin (hcrt) systems that regulate REMS are interconnected, we used mutan …
Restraint stress produces changes in the sleep pattern that are mainly characterized by a delayed increase in rapid eye movement s …
16 results