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Facilitating phenotype transfer using a common data model.
Hripcsak G, Shang N, Peissig PL, Rasmussen LV, Liu C, Benoit B, Carroll RJ, Carrell DS, Denny JC, Dikilitas O, Gainer VS, Howell KM, Klann JG, Kullo IJ, Lingren T, Mentch FD, Murphy SN, Natarajan K, Pacheco JA, Wei WQ, Wiley K, Weng C. Hripcsak G, et al. J Biomed Inform. 2019 Aug;96:103253. doi: 10.1016/j.jbi.2019.103253. Epub 2019 Jul 17. J Biomed Inform. 2019. PMID: 31325501 Free PMC article.
Use of a common data model may facilitate the process. METHODS: Electronic Medical Records and Genomics (eMERGE) sites implemented the Observational Health Data Sciences and Informatics (OHDSI) Observational Medical Outcomes Partnership (OMOP) …
Use of a common data model may facilitate the process. METHODS: Electronic Medical Records and Genomics (eMERGE) …
[Genetic background of preeclampsia].
Seremak-Mrozikiewicz A, Drews K. Seremak-Mrozikiewicz A, et al. Ginekol Pol. 2007 Oct;78(10):802-6. Ginekol Pol. 2007. PMID: 18200973 Review. Polish.
Although a single gene may contribute to the development of the patomechanizm of PE, most authors focus on the analysis of the common influence of candidate genes which are involved in a series of pathophysiological processes of PE. Thus, PE is often believed to be the fin …
Although a single gene may contribute to the development of the patomechanizm of PE, most authors focus on the analysis of the common …
From green to red: horizontal gene transfer of the phycoerythrin gene cluster between Planktothrix strains.
Tooming-Klunderud A, Sogge H, Rounge TB, Nederbragt AJ, Lagesen K, Glöckner G, Hayes PK, Rohrlack T, Jakobsen KS. Tooming-Klunderud A, et al. Appl Environ Microbiol. 2013 Nov;79(21):6803-12. doi: 10.1128/AEM.01455-13. Epub 2013 Aug 30. Appl Environ Microbiol. 2013. PMID: 23995927 Free PMC article.
Horizontal gene transfer is common in cyanobacteria, and transfer of large gene clusters may lead to acquisition of new functions and conceivably niche adaption. ...Our data show that the insertion of a DNA fragment containing the 19.7-kb phycoerythrin …
Horizontal gene transfer is common in cyanobacteria, and transfer of large gene clusters may lead to acquisition of new …
Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii.
Kanatani S, Fuks JM, Olafsson EB, Westermark L, Chambers B, Varas-Godoy M, Uhlén P, Barragan A. Kanatani S, et al. PLoS Pathog. 2017 Dec 7;13(12):e1006739. doi: 10.1371/journal.ppat.1006739. eCollection 2017 Dec. PLoS Pathog. 2017. PMID: 29216332 Free PMC article.
Silencing of Cav1.3 by short hairpin RNA or selective pharmacological antagonism of VDCCs abolished the Toxoplasma-induced hypermigratory phenotype. In a mouse model of toxoplasmosis, VDCC inhibition of adoptively transferred Toxoplasma-infected DCs delayed t …
Silencing of Cav1.3 by short hairpin RNA or selective pharmacological antagonism of VDCCs abolished the Toxoplasma-induced hypermigratory …
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.
Fallon PG, Sasaki T, Sandilands A, Campbell LE, Saunders SP, Mangan NE, Callanan JJ, Kawasaki H, Shiohama A, Kubo A, Sundberg JP, Presland RB, Fleckman P, Shimizu N, Kudoh J, Irvine AD, Amagai M, McLean WH. Fallon PG, et al. Nat Genet. 2009 May;41(5):602-8. doi: 10.1038/ng.358. Epub 2009 Apr 6. Nat Genet. 2009. PMID: 19349982 Free PMC article.
Here we report a 1-bp deletion mutation, 5303delA, analogous to common human FLG mutations, within the murine Flg gene in the spontaneous mouse mutant flaky tail (ft). We demonstrate that topical application of allergen to mice homozygous for this mutation results in cutan …
Here we report a 1-bp deletion mutation, 5303delA, analogous to common human FLG mutations, within the murine Flg gene in the spontan …
Internal transcribed spacer 1 secondary structure analysis reveals a common core throughout the anaerobic fungi (Neocallimastigomycota).
Koetschan C, Kittelmann S, Lu J, Al-Halbouni D, Jarvis GN, Müller T, Wolf M, Janssen PH. Koetschan C, et al. PLoS One. 2014 Mar 24;9(3):e91928. doi: 10.1371/journal.pone.0091928. eCollection 2014. PLoS One. 2014. PMID: 24663345 Free PMC article.
Its highly variable nature predisposes the ITS1 for low level phylogenetics; however, it complicates the establishment of reproducible alignments and the reconstruction of stable phylogenetic trees at higher taxonomic levels (genus and above). Here, we overcame these problems by …
Its highly variable nature predisposes the ITS1 for low level phylogenetics; however, it complicates the establishment of reproducible align …
Selective isolation of extracellular vesicles from minimally processed human plasma as a translational strategy for liquid biopsies.
Fortunato D, Giannoukakos S, Giménez-Capitán A, Hackenberg M, Molina-Vila MA, Zarovni N. Fortunato D, et al. Biomark Res. 2022 Aug 7;10(1):57. doi: 10.1186/s40364-022-00404-1. Biomark Res. 2022. PMID: 35933395 Free PMC article.
The differential clinical value carried within each distinct EV subset highlights the advantages of selective isolation. CONCLUSIONS: This EV isolation protocol facilitated the extraction of clinically useful information from plasma. Compatible with common downstrea …
The differential clinical value carried within each distinct EV subset highlights the advantages of selective isolation. CONCLUSIONS: This E …
Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFκB/c-Myc signaling in female esophageal carcinoma.
Li W, Zhang L, Guo B, Deng J, Wu S, Li F, Wang Y, Lu J, Zhou Y. Li W, et al. Mol Cancer. 2019 Feb 8;18(1):22. doi: 10.1186/s12943-019-0949-7. Mol Cancer. 2019. PMID: 30736860 Free PMC article.
BACKGROUND: Though esophageal cancer is three to four times more common among males than females worldwide, this type of cancer still ranks in the top incidence among women, even more than the female specific cancer types. ...Exosome incubation and co-xenograft assay indic …
BACKGROUND: Though esophageal cancer is three to four times more common among males than females worldwide, this type of cancer still …
Legal agreements and the governance of research commons: lessons from materials sharing in mouse genomics.
Mishra A, Bubela T. Mishra A, et al. OMICS. 2014 Apr;18(4):254-73. doi: 10.1089/omi.2013.0158. Epub 2014 Feb 19. OMICS. 2014. PMID: 24552652 Free PMC article.
Governance includes the use of legal agreements, such as Material Transfer Agreements (MTAs). We analyze the use of such agreements in the mouse research commons, including by two large-scale resource development projects: the International Knockout Mouse Consortium …
Governance includes the use of legal agreements, such as Material Transfer Agreements (MTAs). We analyze the use of such agreements i …