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Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats.
Fadda P, Robinson L, Fratta W, Pertwee RG, Riedel G. Fadda P, et al. Neuropharmacology. 2004 Dec;47(8):1170-9. doi: 10.1016/j.neuropharm.2004.08.009. Neuropharmacology. 2004. PMID: 15567426
Deficits appeared at doses of 2 or 5 mg/kg (i.p.) at both 30 s and 4 h delays and were similar in severity compared with synthetic Delta(9)-THC. ...
Deficits appeared at doses of 2 or 5 mg/kg (i.p.) at both 30 s and 4 h delays and were similar in severity compared with synthetic De …
Inhibition of N-acylethanolamine acid amidase reduces nicotine-induced dopamine activation and reward.
Sagheddu C, Scherma M, Congiu M, Fadda P, Carta G, Banni S, Wood JT, Makriyannis A, Malamas MS, Pistis M. Sagheddu C, et al. Neuropharmacology. 2019 Jan;144:327-336. doi: 10.1016/j.neuropharm.2018.11.013. Epub 2018 Nov 12. Neuropharmacology. 2019. PMID: 30439418
AM11095 (5 and 25 mg/kg, i.p.) was devoid of neurotoxic and behavioral effects and did not affect motor behavior and coordination. This NAAA inhibitor (5 mg/kg i.p.) increased OEA and PEA levels in the hippocampus and cortex, prevented nicotine-induced activation of …
AM11095 (5 and 25 mg/kg, i.p.) was devoid of neurotoxic and behavioral effects and did not affect motor behavior and coordination. Th …
Cannabinoid CB(1) antagonist SR 141716A attenuates reinstatement of heroin self-administration in heroin-abstinent rats.
Fattore L, Spano S, Cossu G, Deiana S, Fadda P, Fratta W. Fattore L, et al. Neuropharmacology. 2005 Jun;48(8):1097-104. doi: 10.1016/j.neuropharm.2005.01.022. Epub 2005 Mar 29. Neuropharmacology. 2005. PMID: 15910886
Adolescent Δ(9)-Tetrahydrocannabinol Exposure Alters WIN55,212-2 Self-Administration in Adult Rats.
Scherma M, Dessì C, Muntoni AL, Lecca S, Satta V, Luchicchi A, Pistis M, Panlilio LV, Fattore L, Goldberg SR, Fratta W, Fadda P. Scherma M, et al. Neuropsychopharmacology. 2016 Apr;41(5):1416-26. doi: 10.1038/npp.2015.295. Epub 2015 Sep 21. Neuropsychopharmacology. 2016. PMID: 26388146 Free PMC article.
Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts.
Fadda P, Robinson L, Fratta W, Pertwee RG, Riedel G. Fadda P, et al. Behav Brain Res. 2006 Apr 3;168(2):307-11. doi: 10.1016/j.bbr.2005.11.022. Epub 2006 Jan 6. Behav Brain Res. 2006. PMID: 16406104
Towards this end, we have recently shown that high concentrations of plant extracts rich in cannabidiol (CBD) can reverse working memory deficits induced by Delta9-THC which is a remaining contaminant of this extract [Fadda P, Robinson L, Fratta W, Pertwee RG, Riede …
Towards this end, we have recently shown that high concentrations of plant extracts rich in cannabidiol (CBD) can reverse working memory def …
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.
Riedel G, Fadda P, McKillop-Smith S, Pertwee RG, Platt B, Robinson L. Riedel G, et al. Br J Pharmacol. 2009 Apr;156(7):1154-66. doi: 10.1111/j.1476-5381.2008.00107.x. Br J Pharmacol. 2009. PMID: 19378378 Free PMC article.
Male and female rats differ in brain cannabinoid CB1 receptor density and function and in behavioural traits predisposing to drug addiction: effect of ovarian hormones.
Castelli MP, Fadda P, Casu A, Spano MS, Casti A, Fratta W, Fattore L. Castelli MP, et al. Curr Pharm Des. 2014;20(13):2100-13. doi: 10.2174/13816128113199990430. Epub 2013 Jul 9. Curr Pharm Des. 2014. PMID: 23829370
The anabolic steroid nandrolone alters cannabinoid self-administration and brain CB1 receptor density and function.
Struik D, Fadda P, Zara T, Zamberletti E, Rubino T, Parolaro D, Fratta W, Fattore L. Struik D, et al. Pharmacol Res. 2017 Jan;115:209-217. doi: 10.1016/j.phrs.2016.11.031. Epub 2016 Nov 24. Pharmacol Res. 2017. PMID: 27890818
Strain and schedule-dependent differences in the acquisition, maintenance and extinction of intravenous cannabinoid self-administration in rats.
Deiana S, Fattore L, Spano MS, Cossu G, Porcu E, Fadda P, Fratta W. Deiana S, et al. Neuropharmacology. 2007 Feb;52(2):646-54. doi: 10.1016/j.neuropharm.2006.09.007. Epub 2006 Nov 13. Neuropharmacology. 2007. PMID: 17098261
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