Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1997 1
1999 1
2002 2
2005 3
2006 4
2007 3
2009 2
2011 4
2012 2
2013 2
2014 3
2015 4
2016 3
2017 6
2018 5
2019 3
2020 1
2021 4
2022 2
2024 3
2025 4
2026 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

61 results

Results by year

Filters applied: . Clear all
Page 1
Editorial: Sulforaphane and isothiocyanates in health.
Fahey JW, Moreno DA, Licciardi P, Grassi F, Karagiannis TC, Mazarakis N. Fahey JW, et al. Front Nutr. 2025 Feb 11;12:1558025. doi: 10.3389/fnut.2025.1558025. eCollection 2025. Front Nutr. 2025. PMID: 40013159 Free PMC article. No abstract available.
Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder.
Zimmerman AW, Singh K, Connors SL, Liu H, Panjwani AA, Lee LC, Diggins E, Foley A, Melnyk S, Singh IN, James SJ, Frye RE, Fahey JW. Zimmerman AW, et al. Among authors: fahey jw. Mol Autism. 2021 May 25;12(1):38. doi: 10.1186/s13229-021-00447-5. Mol Autism. 2021. PMID: 34034808 Free PMC article. Clinical Trial.
BACKGROUND: Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. ...
BACKGROUND: Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) throu …
Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders.
Fahey JW, Liu H, Batt H, Panjwani AA, Tsuji P. Fahey JW, et al. Nutrients. 2025 Apr 15;17(8):1353. doi: 10.3390/nu17081353. Nutrients. 2025. PMID: 40284217 Free PMC article. Review.
Many systemic challenges to the brain can be mitigated by the phytochemical sulforaphane (SF), which is particularly important in supporting mitochondrial function. SF or its biogenic precursor glucoraphanin, from broccoli seeds or sprouts, can confer neuroprotective and c …
Many systemic challenges to the brain can be mitigated by the phytochemical sulforaphane (SF), which is particularly important in sup …
Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial.
Dwibedi C, Axelsson AS, Abrahamsson B, Fahey JW, Asplund O, Hansson O, Ahlqvist E, Tremaroli V, Bäckhed F, Rosengren AH. Dwibedi C, et al. Among authors: fahey jw. Nat Microbiol. 2025 Mar;10(3):681-693. doi: 10.1038/s41564-025-01932-w. Epub 2025 Feb 10. Nat Microbiol. 2025. PMID: 39929977 Free PMC article. Clinical Trial.
More effective treatments are needed for impaired fasting glucose or glucose intolerance, known as prediabetes. Sulforaphane is an isothiocyanate that reduces hepatic gluconeogenesis in individuals with type 2 diabetes and is well tolerated when provided as a broccoli spro …
More effective treatments are needed for impaired fasting glucose or glucose intolerance, known as prediabetes. Sulforaphane is an is …
The Anti-AGEing and RAGEing Potential of Isothiocyanates.
Krisanits BA, Kaur B, Fahey JW, Turner DP. Krisanits BA, et al. Among authors: fahey jw. Molecules. 2024 Dec 19;29(24):5986. doi: 10.3390/molecules29245986. Molecules. 2024. PMID: 39770075 Free PMC article. Review.
Isothiocyanates: Translating the Power of Plants to People.
Palliyaguru DL, Yuan JM, Kensler TW, Fahey JW. Palliyaguru DL, et al. Among authors: fahey jw. Mol Nutr Food Res. 2018 Sep;62(18):e1700965. doi: 10.1002/mnfr.201700965. Epub 2018 Mar 26. Mol Nutr Food Res. 2018. PMID: 29468815 Free PMC article. Review.
Herein, clinical trials employing two isothiocyanates, sulforaphane (SFN; 1-isothiocyanato-4-(methylsulfinyl) butane) and phenethyl isothiocyanate (PEITC; 2-isothiocyanatoethylbenzene) that are isolated principally from broccoli and watercress, respectively, are summarized …
Herein, clinical trials employing two isothiocyanates, sulforaphane (SFN; 1-isothiocyanato-4-(methylsulfinyl) butane) and phenethyl i …
KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane.
Dinkova-Kostova AT, Fahey JW, Kostov RV, Kensler TW. Dinkova-Kostova AT, et al. Among authors: fahey jw. Trends Food Sci Technol. 2017 Nov;69(Pt B):257-269. doi: 10.1016/j.tifs.2017.02.002. Epub 2017 Feb 16. Trends Food Sci Technol. 2017. PMID: 29242678 Free PMC article.
Many putative cellular targets are affected by sulforaphane although only one, KEAP1-NRF2 signaling, can be considered a validated target at this time. ...In many of these settings the antitumorigenic efficacy of sulforaphane is dampened in Nrf2-disrupted animals. B …
Many putative cellular targets are affected by sulforaphane although only one, KEAP1-NRF2 signaling, can be considered a validated ta …
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW. Yagishita Y, et al. Among authors: fahey jw. Molecules. 2019 Oct 6;24(19):3593. doi: 10.3390/molecules24193593. Molecules. 2019. PMID: 31590459 Free PMC article. Review.
There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the plant as its precursor, glucoraphanin, sulforaphane is formed through the actions …
There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the …
Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD).
Liu H, Talalay P, Fahey JW. Liu H, et al. Among authors: fahey jw. CNS Neurol Disord Drug Targets. 2016;15(5):602-13. doi: 10.2174/1871527315666160413120414. CNS Neurol Disord Drug Targets. 2016. PMID: 27071792 Review.
We outline herein, several ASD-associated basic physiological pathways that can be regulated by the small molecule phytochemical sulforaphane, as an example of a druggable small molecule target for which much in vitro, pre-clinical, and clinical evidence already exists: (1 …
We outline herein, several ASD-associated basic physiological pathways that can be regulated by the small molecule phytochemical sulforap …
The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update.
Ramakrishnan M, Fahey JW, Zimmerman AW, Zhou X, Panjwani AA. Ramakrishnan M, et al. Among authors: fahey jw. Front Nutr. 2024 Sep 30;11:1448130. doi: 10.3389/fnut.2024.1448130. eCollection 2024. Front Nutr. 2024. PMID: 39421616 Free PMC article. Review.
Isothiocyanates (ITC) have shown promise in combating oxidative stress and inflammation in the nervous system as well as organ systems. While sulforaphane from broccoli is the most widely studied ITC for biomedical applications, ITC and their precursor glucosinolates are f …
Isothiocyanates (ITC) have shown promise in combating oxidative stress and inflammation in the nervous system as well as organ systems. Whil …
61 results