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Alpha-secretase as a therapeutic target.
Fahrenholz F. Fahrenholz F. Curr Alzheimer Res. 2007 Sep;4(4):412-7. doi: 10.2174/156720507781788837. Curr Alzheimer Res. 2007. PMID: 17908044 Review.
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T. Hata S, et al. Among authors: fahrenholz f. J Biol Chem. 2009 Dec 25;284(52):36024-36033. doi: 10.1074/jbc.M109.057497. Epub 2009 Oct 28. J Biol Chem. 2009. PMID: 19864413 Free PMC article.
Regulation of α-secretase ADAM10 expression and activity.
Endres K, Fahrenholz F. Endres K, et al. Among authors: fahrenholz f. Exp Brain Res. 2012 Apr;217(3-4):343-52. doi: 10.1007/s00221-011-2885-7. Epub 2011 Oct 4. Exp Brain Res. 2012. PMID: 21969210 Review.
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