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Surface receptors and transporters of Trypanosoma brucei.
Borst P, Fairlamb AH. Borst P, et al. Annu Rev Microbiol. 1998;52:745-78. doi: 10.1146/annurev.micro.52.1.745. Annu Rev Microbiol. 1998. PMID: 9891812 Review.
The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.
Dewar S, Sienkiewicz N, Ong HB, Wall RJ, Horn D, Fairlamb AH. Dewar S, et al. J Biol Chem. 2016 Nov 18;291(47):24768-24778. doi: 10.1074/jbc.M116.750422. Epub 2016 Oct 4. J Biol Chem. 2016. PMID: 27703008 Free PMC article.
Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.
Ong HB, Sienkiewicz N, Wyllie S, Patterson S, Fairlamb AH. Ong HB, et al. Mol Microbiol. 2013 Oct;90(2):443-55. doi: 10.1111/mmi.12376. Epub 2013 Sep 9. Mol Microbiol. 2013. PMID: 23980694 Free PMC article.
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.
Wyllie S, Oza SL, Patterson S, Spinks D, Thompson S, Fairlamb AH. Wyllie S, et al. Mol Microbiol. 2009 Nov;74(3):529-40. doi: 10.1111/j.1365-2958.2009.06761.x. Epub 2009 Jun 24. Mol Microbiol. 2009. PMID: 19558432 Free PMC article.
Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.
Dawson A, Gibellini F, Sienkiewicz N, Tulloch LB, Fyfe PK, McLuskey K, Fairlamb AH, Hunter WN. Dawson A, et al. Mol Microbiol. 2006 Sep;61(6):1457-68. doi: 10.1111/j.1365-2958.2006.05332.x. Mol Microbiol. 2006. PMID: 16968221 Free PMC article.
Properties of trypanothione synthetase from Trypanosoma brucei.
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH. Oza SL, et al. Mol Biochem Parasitol. 2003 Sep;131(1):25-33. doi: 10.1016/s0166-6851(03)00176-2. Mol Biochem Parasitol. 2003. PMID: 12967709
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F. Shameer S, et al. Nucleic Acids Res. 2015 Jan;43(Database issue):D637-44. doi: 10.1093/nar/gku944. Epub 2014 Oct 9. Nucleic Acids Res. 2015. PMID: 25300491 Free PMC article.
Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.
Ong HB, Lee WS, Patterson S, Wyllie S, Fairlamb AH. Ong HB, et al. Mol Microbiol. 2015 Jan;95(1):143-56. doi: 10.1111/mmi.12853. Epub 2014 Nov 25. Mol Microbiol. 2015. PMID: 25367138 Free PMC article.
The genome of the African trypanosome Trypanosoma brucei.
Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Böhme U, Hannick L, Aslett MA, Shallom J, Marcello L, Hou L, Wickstead B, Alsmark UC, Arrowsmith C, Atkin RJ, Barron AJ, Bringaud F, Brooks K, Carrington M, Cherevach I, Chillingworth TJ, Churcher C, Clark LN, Corton CH, Cronin A, Davies RM, Doggett J, Djikeng A, Feldblyum T, Field MC, Fraser A, Goodhead I, Hance Z, Harper D, Harris BR, Hauser H, Hostetler J, Ivens A, Jagels K, Johnson D, Johnson J, Jones K, Kerhornou AX, Koo H, Larke N, Landfear S, Larkin C, Leech V, Line A, Lord A, Macleod A, Mooney PJ, Moule S, Martin DM, Morgan GW, Mungall K, Norbertczak H, Ormond D, Pai G, Peacock CS, Peterson J, Quail MA, Rabbinowitsch E, Rajandream MA, Reitter C, Salzberg SL, Sanders M, Schobel S, Sharp S, Simmonds M, Simpson AJ, Tallon L, Turner CM, Tait A, Tivey AR, Van Aken S, Walker D, Wanless D, Wang S, White B, White O, Whitehead S, Woodward J, Wortman J, Adams MD, Embley TM, Gull K, Ullu E, Barry JD, Fairlamb AH, Opperdoes F, Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE, El-Sayed NM. Berriman M, et al. Science. 2005 Jul 15;309(5733):416-22. doi: 10.1126/science.1112642. Science. 2005. PMID: 16020726
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