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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1964 1
1965 2
1967 1
1968 5
1969 1
1970 3
1971 3
1972 3
1973 1
1974 1
1975 2
1977 2
1979 3
1980 3
1981 1
1982 2
1983 1
1987 2
1989 2
1990 1
1991 1
1992 2
1993 2
1994 1
1995 1
1996 1
1997 3
1998 2
1999 2
2000 3
2001 1
2002 1
2003 2
2004 2
2005 4
2006 3
2007 2
2008 2
2009 5
2010 6
2011 3
2012 1
2013 10
2014 13
2015 6
2016 7
2017 4
2018 6
2019 7
2020 8
2021 8
2022 4
2023 5
2024 1

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155 results

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Page 1
Biology of human sodium glucose transporters.
Wright EM, Loo DD, Hirayama BA. Wright EM, et al. Physiol Rev. 2011 Apr;91(2):733-94. doi: 10.1152/physrev.00055.2009. Physiol Rev. 2011. PMID: 21527736 Free article. Review.
We also discuss the physiology and pathophysiology of SGLTs, e.g., glucose galactose malabsorption and familial renal glycosuria, and briefly report on targeting of SGLTs for new therapies for diabetes....
We also discuss the physiology and pathophysiology of SGLTs, e.g., glucose galactose malabsorption and familial renal glyco
Phlorizin: a review.
Ehrenkranz JR, Lewis NG, Kahn CR, Roth J. Ehrenkranz JR, et al. Diabetes Metab Res Rev. 2005 Jan-Feb;21(1):31-8. doi: 10.1002/dmrr.532. Diabetes Metab Res Rev. 2005. PMID: 15624123 Review.
It has been used as a pharmaceutical and tool for physiology research for over 150 years. Phlorizin's principal pharmacological action is to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters located …
It has been used as a pharmaceutical and tool for physiology research for over 150 years. Phlorizin's principal pharmacological action is to …
SGLT2-inhibitors; more than just glycosuria and diuresis.
Fathi A, Vickneson K, Singh JS. Fathi A, et al. Heart Fail Rev. 2021 May;26(3):623-642. doi: 10.1007/s10741-020-10038-w. Epub 2020 Dec 4. Heart Fail Rev. 2021. PMID: 33274396 Free PMC article. Review.
The sodium-glucose linked cotransporter subtype 2 (SGLT2)-inhibitor class, which was initially developed as a treatment for T2DM, has shown great promise in reducing cardiovascular risk, particularly around HF outcomes - regardless of diabetes status.There are ongoing efforts to …
The sodium-glucose linked cotransporter subtype 2 (SGLT2)-inhibitor class, which was initially developed as a treatment for T2DM, has shown …
Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.
Ghezzi C, Loo DDF, Wright EM. Ghezzi C, et al. Diabetologia. 2018 Oct;61(10):2087-2097. doi: 10.1007/s00125-018-4656-5. Epub 2018 Aug 22. Diabetologia. 2018. PMID: 30132032 Free PMC article. Review.
Here we summarise the current state of our knowledge about the physiology of renal glucose handling and provide background to the development of SGLT2 inhibitors for type 2 diabetes treatment....
Here we summarise the current state of our knowledge about the physiology of renal glucose handling and provide background to the dev …
Clinical pharmacology of SGLT-2 inhibitors in heart failure.
Velliou M, Polyzogopoulou E, Ventoulis I, Parissis J. Velliou M, et al. Expert Rev Clin Pharmacol. 2023 Feb;16(2):149-160. doi: 10.1080/17512433.2023.2173574. Epub 2023 Feb 2. Expert Rev Clin Pharmacol. 2023. PMID: 36701817 Review.
AREAS COVERED: Ongoing efforts to clarify the exact mechanisms of action of SGLT2 inhibitors (SGLT2i) reveal that glycosuria and osmotic diuresis, resulting from the blockade of renal receptors, is not the sole pathophysiological mechanism. ...
AREAS COVERED: Ongoing efforts to clarify the exact mechanisms of action of SGLT2 inhibitors (SGLT2i) reveal that glycosuria and osmo …
Renal glucosuria.
Brodehl J, Oemar BS, Hoyer PF. Brodehl J, et al. Pediatr Nephrol. 1987 Jul;1(3):502-8. doi: 10.1007/BF00849261. Pediatr Nephrol. 1987. PMID: 3153324 Review.
Normal urine contains small amounts of glucose, called basal glucosuria, and other carbohydrates. Increased amounts of glucose beyond the basal excretion rates i.e. frank glucosuria, reflect reduced activity of tubular glucose reabsorption. Clinically, there are two …
Normal urine contains small amounts of glucose, called basal glucosuria, and other carbohydrates. Increased amounts of glucose beyond …
Glucose transporters.
Elsas LJ, Longo N. Elsas LJ, et al. Annu Rev Med. 1992;43:377-93. doi: 10.1146/annurev.me.43.020192.002113. Annu Rev Med. 1992. PMID: 1580597 Review.
Two classes of glucose transporters transfer glucose across the plasma membrane of human cells. In epithelial cells lining the jejunum and proximal renal tubules, Na+/glucose cotransporters concentrate glucose inside cells using the transmembrane electrochemical potential …
Two classes of glucose transporters transfer glucose across the plasma membrane of human cells. In epithelial cells lining the jejunum and p …
SGLT1 inhibition: Pros and cons.
Tsimihodimos V, Filippas-Ntekouan S, Elisaf M. Tsimihodimos V, et al. Eur J Pharmacol. 2018 Nov 5;838:153-156. doi: 10.1016/j.ejphar.2018.09.019. Epub 2018 Sep 18. Eur J Pharmacol. 2018. PMID: 30240793 Review.
Sodium Glucose Cotransporters 1 (SGLT1) play important roles in the intestinal absorption of glucose and the renal reabsorption of glucose, especially in patients with uncontrolled diabetes and those receiving SGLT2 inhibitors. ...The inhibition of SGLT1 lowers serum gluco …
Sodium Glucose Cotransporters 1 (SGLT1) play important roles in the intestinal absorption of glucose and the renal reabsorption of gl …
▼ Empagliflozin, diabetes and outcomes.
[No authors listed] [No authors listed] Drug Ther Bull. 2016 Jul;54(7):78-81. doi: 10.1136/dtb.2016.6.0411. Drug Ther Bull. 2016. PMID: 27417322 Review.
It was launched in August 2014, and acts in a similar way to the other SGLT2 inhibitors, dapagliflozin and canagliflozin, by inhibiting renal glucose resorption and promoting glycosuria.(6) It is indicated for the treatment of type 2 diabetes in adults to improve gl …
It was launched in August 2014, and acts in a similar way to the other SGLT2 inhibitors, dapagliflozin and canagliflozin, by inhibiting r
Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target.
Santer R, Calado J. Santer R, et al. Clin J Am Soc Nephrol. 2010 Jan;5(1):133-41. doi: 10.2215/CJN.04010609. Epub 2009 Nov 5. Clin J Am Soc Nephrol. 2010. PMID: 19965550 Review.
Mutations in SGLT1 are associated with glucose-galactose malabsorption, SGLT2 with familial renal glucosuria (FRG), and GLUT2 with Fanconi-Bickel syndrome. ...Glucosuria in these patients can range from <1 to >150 g/1.73 m(2) per d. ...
Mutations in SGLT1 are associated with glucose-galactose malabsorption, SGLT2 with familial renal glucosuria (FRG), and …
155 results