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Page 1
Stem cell approaches for tendon repair: delusion or insight.
Kar S, Zhang E, Moonilall A, Gordon D, Fang F. Kar S, et al. Among authors: fang f. J Physiol. 2025 Dec;603(23):7483-7498. doi: 10.1113/JP286698. Epub 2025 Apr 11. J Physiol. 2025. PMID: 40214977 Review.
Tendon injuries are a common and significant health burden around the world. Current treatment strategies are unable to fully restore tendon structure and function. To address these critical clinical needs, stem cell therapy has recently emerged as a promising appro …
Tendon injuries are a common and significant health burden around the world. Current treatment strategies are unable to fully restore …
Hedgehog Activation for Enhanced Rotator Cuff Tendon-to-Bone Healing.
Luzzi AJ, Ferrer X, Fang F, Golman M, Song L, Marshall BP, Lee AJ, Kim JJ, Hung CT, Thomopoulos S. Luzzi AJ, et al. Among authors: fang f. Am J Sports Med. 2023 Dec;51(14):3825-3834. doi: 10.1177/03635465231203210. Epub 2023 Oct 28. Am J Sports Med. 2023. PMID: 37897335 Free PMC article.
HYPOTHESIS: Hedgehog activation improves tendon-to-bone healing in an animal model of rotator cuff repair. STUDY DESIGN: Controlled laboratory study. ...CONCLUSION: Hedgehog agonist treatment activated hedgehog signaling at the tendon-to-bone repair site and prompte …
HYPOTHESIS: Hedgehog activation improves tendon-to-bone healing in an animal model of rotator cuff repair. STUDY DESIGN: Controlled l …
A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential.
Fang F, Xiao Y, Zelzer E, Leong KW, Thomopoulos S. Fang F, et al. Cell Stem Cell. 2022 Dec 1;29(12):1669-1684.e6. doi: 10.1016/j.stem.2022.11.007. Cell Stem Cell. 2022. PMID: 36459968 Free PMC article.
The enthesis, a fibrocartilaginous transition between tendon and bone, is necessary for force transfer from muscle to bone to produce joint motion. ...
The enthesis, a fibrocartilaginous transition between tendon and bone, is necessary for force transfer from muscle to bone to produce …
Mechanically Competent Chitosan-Based Bioadhesive for Tendon-to-Bone Repair.
Fang F, Linstadt RTH, Genin GM, Ahn K, Thomopoulos S. Fang F, et al. Adv Healthc Mater. 2022 May;11(10):e2102344. doi: 10.1002/adhm.202102344. Epub 2022 Jan 22. Adv Healthc Mater. 2022. PMID: 35026059 Free PMC article.
Current suture-based surgical techniques used to repair torn rotator cuff tendons do not result in mechanically competent tendon-to-bone attachments, leading to high postoperative failure rates. ...Results demonstrated that the bioadhesive has the potential to impro …
Current suture-based surgical techniques used to repair torn rotator cuff tendons do not result in mechanically competent tendon …
Hedgehog signaling underlying tendon and enthesis development and pathology.
Fang F, Sup M, Luzzi A, Ferrer X, Thomopoulos S. Fang F, et al. Matrix Biol. 2022 Jan;105:87-103. doi: 10.1016/j.matbio.2021.12.001. Epub 2021 Dec 24. Matrix Biol. 2022. PMID: 34954379 Free PMC article. Review.
However, aberrant Hh signaling can also lead to pathologic heterotopic ossification in tendon or osteophyte formation at the enthesis. Therefore, the therapeutic potential of Hh signaling modulation for treating tendon and enthesis diseases remains uncertain. For ex …
However, aberrant Hh signaling can also lead to pathologic heterotopic ossification in tendon or osteophyte formation at the enthesis …
The role of loading in murine models of rotator cuff disease.
Abraham AC, Fang F, Golman M, Oikonomou P, Thomopoulos S. Abraham AC, et al. Among authors: fang f. J Orthop Res. 2022 Apr;40(4):977-986. doi: 10.1002/jor.25113. Epub 2021 Jun 13. J Orthop Res. 2022. PMID: 34081350 Free PMC article.
Mice were subjected to one of three load-dependent rotator cuff tendinopathy models: underuse loading, achieved by injecting botulinum toxin-A into the supraspinatus muscle; overuse loading, achieved using downhill treadmill running; destabilization loading, achieved by su …
Mice were subjected to one of three load-dependent rotator cuff tendinopathy models: underuse loading, achieved by injecting botulinu …
Primary cilia as the nexus of biophysical and hedgehog signaling at the tendon enthesis.
Fang F, Schwartz AG, Moore ER, Sup ME, Thomopoulos S. Fang F, et al. Sci Adv. 2020 Oct 30;6(44):eabc1799. doi: 10.1126/sciadv.abc1799. Print 2020 Oct. Sci Adv. 2020. PMID: 33127677 Free PMC article.
The tendon enthesis is a fibrocartilaginous tissue critical for transfer of muscle forces to bone. Enthesis pathologies are common, and surgical repair of tendon to bone is plagued by high failure rates. At the root of these failures is a gap in knowledge of how the …
The tendon enthesis is a fibrocartilaginous tissue critical for transfer of muscle forces to bone. Enthesis pathologies are common, a …
Multiscale mechanical effects of native collagen cross-linking in tendon.
Eekhoff JD, Fang F, Lake SP. Eekhoff JD, et al. Among authors: fang f. Connect Tissue Res. 2018 Sep;59(5):410-422. doi: 10.1080/03008207.2018.1449837. Epub 2018 Jun 6. Connect Tissue Res. 2018. PMID: 29873266 Review.
As a result, glycation has been proposed to primarily impact tendon mechanics by altering molecular interactions at the fiber interface, thereby diminishing sliding between fibers. Thus, increased nonenzymatic cross-linking decreases microscale strain attenuation and the v …
As a result, glycation has been proposed to primarily impact tendon mechanics by altering molecular interactions at the fiber interfa …
Functionally Distinct Tendons From Elastin Haploinsufficient Mice Exhibit Mild Stiffening and Tendon-Specific Structural Alteration.
Eekhoff JD, Fang F, Kahan LG, Espinosa G, Cocciolone AJ, Wagenseil JE, Mecham RP, Lake SP. Eekhoff JD, et al. Among authors: fang f. J Biomech Eng. 2017 Nov 1;139(11):1110031-9. doi: 10.1115/1.4037932. J Biomech Eng. 2017. PMID: 28916838 Free PMC article.
While elastic fibers have long been known to be significant in the mechanics of elastin-rich tissue (i.e., vasculature, skin, lungs), recent studies have suggested a mechanical role for elastic fibers in tendons that is dependent on specific tendon function. However …
While elastic fibers have long been known to be significant in the mechanics of elastin-rich tissue (i.e., vasculature, skin, lungs), recent …
Multiscale Mechanical Evaluation of Human Supraspinatus Tendon Under Shear Loading After Glycosaminoglycan Reduction.
Fang F, Lake SP. Fang F, et al. J Biomech Eng. 2017 Jul 1;139(7):0710131-8. doi: 10.1115/1.4036602. J Biomech Eng. 2017. PMID: 28462418 Free PMC article.
Although PGs, consisting of a core protein and glycosaminoglycan (GAG) sidechains, were once hypothesized to regulate stress/strain transfer between collagen fibrils and help support load in tendon, several studies have reported no changes to tensile mechanics after GAG de …
Although PGs, consisting of a core protein and glycosaminoglycan (GAG) sidechains, were once hypothesized to regulate stress/strain transfer …
Experimental evaluation of multiscale tendon mechanics.
Fang F, Lake SP. Fang F, et al. J Orthop Res. 2017 Jul;35(7):1353-1365. doi: 10.1002/jor.23488. Epub 2017 Apr 19. J Orthop Res. 2017. PMID: 27878999 Free article. Review.
Tendon's primary function is a mechanical link between muscle and bone. The hierarchical structure of tendon and specific compositional constituents are believed to be critical for proper mechanical function. With increased appreciation for tendon impo …
Tendon's primary function is a mechanical link between muscle and bone. The hierarchical structure of tendon and specif …
Multiscale mechanical integrity of human supraspinatus tendon in shear after elastin depletion.
Fang F, Lake SP. Fang F, et al. J Mech Behav Biomed Mater. 2016 Oct;63:443-455. doi: 10.1016/j.jmbbm.2016.06.032. Epub 2016 Jul 7. J Mech Behav Biomed Mater. 2016. PMID: 27472764
Human supraspinatus tendon (SST) exhibits region-specific nonlinear mechanical properties under tension, which have been attributed to its complex multiaxial physiological loading environment. ...These results show that elastin contributes to tendon mechanics in she …
Human supraspinatus tendon (SST) exhibits region-specific nonlinear mechanical properties under tension, which have been attributed t …
Modelling approaches for evaluating multiscale tendon mechanics.
Fang F, Lake SP. Fang F, et al. Interface Focus. 2016 Feb 6;6(1):20150044. doi: 10.1098/rsfs.2015.0044. Interface Focus. 2016. PMID: 26855747 Free PMC article.
Tendon exhibits anisotropic, inhomogeneous and viscoelastic mechanical properties that are determined by its complicated hierarchical structure and varying amounts/organization of different tissue constituents. ...Multiscale modelling approaches incorporating tendon …
Tendon exhibits anisotropic, inhomogeneous and viscoelastic mechanical properties that are determined by its complicated hierarchical …
Multiscale strain analysis of tendon subjected to shear and compression demonstrates strain attenuation, fiber sliding, and reorganization.
Fang F, Lake SP. Fang F, et al. J Orthop Res. 2015 Nov;33(11):1704-12. doi: 10.1002/jor.22955. Epub 2015 Jul 14. J Orthop Res. 2015. PMID: 26036894 Free article.
How tendons deform in different hierarchical levels under shear and compression is unknown. The aims of this study were: (i) to evaluate whether specific regions of bovine deep digital flexor tendons exhibited different strain attenuation from macro to micro length …
How tendons deform in different hierarchical levels under shear and compression is unknown. The aims of this study were: (i) to evalu …
Different regions of bovine deep digital flexor tendon exhibit distinct elastic, but not viscous, mechanical properties under both compression and shear loading.
Fang F, Sawhney AS, Lake SP. Fang F, et al. J Biomech. 2014 Sep 22;47(12):2869-77. doi: 10.1016/j.jbiomech.2014.07.026. Epub 2014 Jul 30. J Biomech. 2014. PMID: 25113805
Tendons in different locations function in unique, and at times complex, in vivo loading environments. Specifically, some tendons are subjected to compression, shear and/or torsion in addition to tensile loading, which play an important role in regulating tendon …
Tendons in different locations function in unique, and at times complex, in vivo loading environments. Specifically, some tendons …