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The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors.
Liu SK, Fang N, Koretzky GA, McGlade CJ. Liu SK, et al. Among authors: fang n. Curr Biol. 1999 Jan 28;9(2):67-75. doi: 10.1016/s0960-9822(99)80017-7. Curr Biol. 1999. PMID: 10021361
SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors.
Binstadt BA, Billadeau DD, Jevremović D, Williams BL, Fang N, Yi T, Koretzky GA, Abraham RT, Leibson PJ. Binstadt BA, et al. Among authors: fang n. J Biol Chem. 1998 Oct 16;273(42):27518-23. doi: 10.1074/jbc.273.42.27518. J Biol Chem. 1998. PMID: 9765283
SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity.
Fang N, Koretzky GA. Fang N, et al. J Biol Chem. 1999 Jun 4;274(23):16206-12. doi: 10.1074/jbc.274.23.16206. J Biol Chem. 1999. PMID: 10347175
Adaptor proteins in lymphocyte antigen-receptor signaling.
Peterson EJ, Clements JL, Fang N, Koretzky GA. Peterson EJ, et al. Among authors: fang n. Curr Opin Immunol. 1998 Jun;10(3):337-44. doi: 10.1016/s0952-7915(98)80173-8. Curr Opin Immunol. 1998. PMID: 9638371 Review.
Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.
Fang N, Motto DG, Ross SE, Koretzky GA. Fang N, et al. J Immunol. 1996 Nov 1;157(9):3769-73. J Immunol. 1996. PMID: 8892604 Review.
Three domains of SLP-76 are required for its optimal function in a T cell line.
Musci MA, Motto DG, Ross SE, Fang N, Koretzky GA. Musci MA, et al. Among authors: fang n. J Immunol. 1997 Aug 15;159(4):1639-47. J Immunol. 1997. PMID: 9257823
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.
Fang D, Wang HY, Fang N, Altman Y, Elly C, Liu YC. Fang D, et al. Among authors: fang n. J Biol Chem. 2001 Feb 16;276(7):4872-8. doi: 10.1074/jbc.M008901200. Epub 2000 Nov 21. J Biol Chem. 2001. PMID: 11087752
Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase.
Qiu L, Joazeiro C, Fang N, Wang HY, Elly C, Altman Y, Fang D, Hunter T, Liu YC. Qiu L, et al. Among authors: fang n, fang d. J Biol Chem. 2000 Nov 17;275(46):35734-7. doi: 10.1074/jbc.M007300200. J Biol Chem. 2000. PMID: 10940313
Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.
Fang NN, Chan GT, Zhu M, Comyn SA, Persaud A, Deshaies RJ, Rotin D, Gsponer J, Mayor T. Fang NN, et al. Nat Cell Biol. 2014 Dec;16(12):1227-37. doi: 10.1038/ncb3054. Epub 2014 Oct 26. Nat Cell Biol. 2014. PMID: 25344756 Free PMC article.
Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.
Fang D, Elly C, Gao B, Fang N, Altman Y, Joazeiro C, Hunter T, Copeland N, Jenkins N, Liu YC. Fang D, et al. Among authors: fang n. Nat Immunol. 2002 Mar;3(3):281-7. doi: 10.1038/ni763. Epub 2002 Feb 4. Nat Immunol. 2002. PMID: 11828324
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