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Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma.
Farinha P, Gascoyne RD. Farinha P, et al. J Clin Oncol. 2005 Sep 10;23(26):6370-8. doi: 10.1200/JCO.2005.05.011. J Clin Oncol. 2005. PMID: 16155022 Review.
Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray.
Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Müller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, Falini B, Banham AH, Rosenwald A, Staudt LM, Connors JM, Armitage JO, Chan WC. Hans CP, et al. Blood. 2004 Jan 1;103(1):275-82. doi: 10.1182/blood-2003-05-1545. Epub 2003 Sep 22. Blood. 2004. PMID: 14504078
Expression of bcl-6 (P <.001) or CD10 (P =.019) was associated with better overall survival (OS), whereas expression of MUM1 (P =.009) or cyclin D2 (P <.001) was associated with worse OS. ...In multivariate analysis, a high International Prognost …
Expression of bcl-6 (P <.001) or CD10 (P =.019) was associated with better overall survival (OS), whereas expression of MUM …
Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma.
Banham AH, Connors JM, Brown PJ, Cordell JL, Ott G, Sreenivasan G, Farinha P, Horsman DE, Gascoyne RD. Banham AH, et al. Clin Cancer Res. 2005 Feb 1;11(3):1065-72. Clin Cancer Res. 2005. PMID: 15709173
The overall survival curves clearly showed that patients grouped as FOXP1-positive (40%) had a significantly decreased overall survival (P = 0.0001). ...
The overall survival curves clearly showed that patients grouped as FOXP1-positive (40%) had a significantly decreased overall survival ( …
Helicobacter pylori and MALT lymphoma.
Farinha P, Gascoyne RD. Farinha P, et al. Gastroenterology. 2005 May;128(6):1579-605. doi: 10.1053/j.gastro.2005.03.083. Gastroenterology. 2005. PMID: 15887153 Review. No abstract available.
Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL).
Farinha P, Masoudi H, Skinnider BF, Shumansky K, Spinelli JJ, Gill K, Klasa R, Voss N, Connors JM, Gascoyne RD. Farinha P, et al. Blood. 2005 Sep 15;106(6):2169-74. doi: 10.1182/blood-2005-04-1565. Epub 2005 Jun 2. Blood. 2005. PMID: 15933054
The International Prognostic Index (IPI) was predictive of overall survival (OS) (P = .003). Biopsy specimens from all cases were stained with an anti-CD68 antibody. ...A multivariate Cox model that included the IPI score, the histologic grade, and the lymphoma-associated …
The International Prognostic Index (IPI) was predictive of overall survival (OS) (P = .003). Biopsy specimens from all cases were sta …
LMO2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with anthracycline-based chemotherapy with and without rituximab.
Natkunam Y, Farinha P, Hsi ED, Hans CP, Tibshirani R, Sehn LH, Connors JM, Gratzinger D, Rosado M, Zhao S, Pohlman B, Wongchaowart N, Bast M, Avigdor A, Schiby G, Nagler A, Byrne GE, Levy R, Gascoyne RD, Lossos IS. Natkunam Y, et al. J Clin Oncol. 2008 Jan 20;26(3):447-54. doi: 10.1200/JCO.2007.13.0690. Epub 2007 Dec 17. J Clin Oncol. 2008. PMID: 18086797 Clinical Trial.
RESULTS: In anthracycline-treated patients, LMO2 protein expression was significantly correlated with improved overall survival (OS) and progression-free survival (PFS) in univariate analyses (OS, P = .018; PFS, P = .010) and was a significant predictor independent …
RESULTS: In anthracycline-treated patients, LMO2 protein expression was significantly correlated with improved overall survival (OS) and pro …
MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy.
Savage KJ, Johnson NA, Ben-Neriah S, Connors JM, Sehn LH, Farinha P, Horsman DE, Gascoyne RD. Savage KJ, et al. Blood. 2009 Oct 22;114(17):3533-7. doi: 10.1182/blood-2009-05-220095. Epub 2009 Aug 24. Blood. 2009. PMID: 19704118
MYC+ DLBCL was associated with an inferior 5-year progression-free survival (66% vs 31%, P = .006) and overall survival (72% vs 33%, P = .016). Multivariate analysis confirmed the prognostic importance of MYC for both progression-free survival (hazard ratio = 3.28; …
MYC+ DLBCL was associated with an inferior 5-year progression-free survival (66% vs 31%, P = .006) and overall survival (72% vs 33%, …
Correlations between BCL6 rearrangement and outcome in patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP.
Shustik J, Han G, Farinha P, Johnson NA, Ben Neriah S, Connors JM, Sehn LH, Horsman DE, Gascoyne RD, Steidl C. Shustik J, et al. Haematologica. 2010 Jan;95(1):96-101. doi: 10.3324/haematol.2009.007203. Epub 2009 Oct 1. Haematologica. 2010. PMID: 19797725 Free PMC article.
The presence of the gene rearrangement was associated with a non-germinal center B-cell immunophenotype (P=0.006), and showed no correlation with BCL6 protein expression. A trend toward inferior overall survival was observed in association with the BCL6 rearrangement among …
The presence of the gene rearrangement was associated with a non-germinal center B-cell immunophenotype (P=0.006), and showed no corr …
The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation.
Farinha P, Al-Tourah A, Gill K, Klasa R, Connors JM, Gascoyne RD. Farinha P, et al. Blood. 2010 Jan 14;115(2):289-95. doi: 10.1182/blood-2009-07-235598. Epub 2009 Nov 9. Blood. 2010. PMID: 19901260
The International Prognostic Index score predicted overall survival (OS; P = .004) but not risk of transformation (RT). Cell content did not impact survival, while immunoarchitectural patterns of CD4/CD8 were significant for progression-free survival (PFS; P = .056) …
The International Prognostic Index score predicted overall survival (OS; P = .004) but not risk of transformation (RT). Cell content …
Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP.
Evens AM, Sehn LH, Farinha P, Nelson BP, Raji A, Lu Y, Brakman A, Parimi V, Winter JN, Schumacker PT, Gascoyne RD, Gordon LI. Evens AM, et al. J Clin Oncol. 2010 Feb 20;28(6):1017-24. doi: 10.1200/JCO.2009.24.1893. Epub 2010 Jan 4. J Clin Oncol. 2010. PMID: 20048181 Free PMC article.
Five-year PFS for HIF-1alpha-positive patients was 71% v 43% for HIF-1alpha-negative patients (P = .0187), whereas 5-year OS was 75% and 54%, respectively (P = .025). In multivariate analysis with International Prognostic Index criteria, HIF-1alpha remained a signif …
Five-year PFS for HIF-1alpha-positive patients was 71% v 43% for HIF-1alpha-negative patients (P = .0187), whereas 5-year OS was 75% …
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