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Unveiling the role of network and systems biology in drug discovery.
Pujol A, Mosca R, Farrés J, Aloy P. Pujol A, et al. Among authors: farres j. Trends Pharmacol Sci. 2010 Mar;31(3):115-23. doi: 10.1016/j.tips.2009.11.006. Epub 2010 Feb 1. Trends Pharmacol Sci. 2010. PMID: 20117850 Review.
Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet.
Farrés J, Pujol A, Coma M, Ruiz JL, Naval J, Mas JM, Molins A, Fondevila J, Aloy P. Farrés J, et al. Nutr Metab (Lond). 2010 Dec 9;7:88. doi: 10.1186/1743-7075-7-88. Nutr Metab (Lond). 2010. PMID: 21143928 Free PMC article.
Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy.
Kraft C, Boya P, Codogno P, Elazar Z, Eskelinen EL, Farrés J, Kirkin V, Jungbluth H, Martinez A, Pless O, Primard C, Proikas-Cezanne T, Simonsen A, Reggiori F. Kraft C, et al. Among authors: farres j. Autophagy. 2019 Feb;15(2):347-351. doi: 10.1080/15548627.2018.1515532. Epub 2018 Sep 13. Autophagy. 2019. PMID: 30176150 Free PMC article.
In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm.
Artigas L, Coma M, Matos-Filipe P, Aguirre-Plans J, Farrés J, Valls R, Fernandez-Fuentes N, de la Haba-Rodriguez J, Olvera A, Barbera J, Morales R, Oliva B, Mas JM. Artigas L, et al. Among authors: farres j. PLoS One. 2020 Oct 2;15(10):e0240149. doi: 10.1371/journal.pone.0240149. eCollection 2020. PLoS One. 2020. PMID: 33006999 Free PMC article.
Synthesis of C11-to-C14 methyl-shifted all-trans-retinal analogues and their activities on human aldo-keto reductases.
Rivas A, Pequerul R, Barracco V, Domínguez M, López S, Jiménez R, Parés X, Alvarez R, Farrés J, de Lera AR. Rivas A, et al. Among authors: farres j. Org Biomol Chem. 2020 Jul 1;18(25):4788-4801. doi: 10.1039/d0ob01084g. Org Biomol Chem. 2020. PMID: 32530010
Structural and kinetic features of aldehyde dehydrogenase 1A (ALDH1A) subfamily members, cancer stem cell markers active in retinoic acid biosynthesis.
Pequerul R, Vera J, Giménez-Dejoz J, Crespo I, Coines J, Porté S, Rovira C, Parés X, Farrés J. Pequerul R, et al. Among authors: farres j. Arch Biochem Biophys. 2020 Mar 15;681:108256. doi: 10.1016/j.abb.2020.108256. Epub 2020 Jan 7. Arch Biochem Biophys. 2020. PMID: 31923393
Engineering aldo-keto reductase 1B10 to mimic the distinct 1B15 topology and specificity towards inhibitors and substrates, including retinoids and steroids.
Giménez-Dejoz J, Weber S, Fernández-Pardo Á, Möller G, Adamski J, Porté S, Parés X, Farrés J. Giménez-Dejoz J, et al. Among authors: farres j. Chem Biol Interact. 2019 Jul 1;307:186-194. doi: 10.1016/j.cbi.2019.04.030. Epub 2019 Apr 24. Chem Biol Interact. 2019. PMID: 31028727
Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function.
Galindo-Campos MA, Bedora-Faure M, Farrés J, Lescale C, Moreno-Lama L, Martínez C, Martín-Caballero J, Ampurdanés C, Aparicio P, Dantzer F, Cerutti A, Deriano L, Yélamos J. Galindo-Campos MA, et al. Among authors: farres j. Cell Death Differ. 2019 Dec;26(12):2667-2681. doi: 10.1038/s41418-019-0326-5. Epub 2019 Apr 17. Cell Death Differ. 2019. PMID: 30996287 Free PMC article.
Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells.
Jiménez R, Pequerul R, Amor A, Lorenzo J, Metwally K, Avilés FX, Parés X, Farrés J. Jiménez R, et al. Among authors: farres j. Chem Biol Interact. 2019 Jun 1;306:123-130. doi: 10.1016/j.cbi.2019.04.004. Epub 2019 Apr 5. Chem Biol Interact. 2019. PMID: 30958995
Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation.
Castellví A, Crespo I, Crosas E, Cámara-Artigas A, Gavira JA, Aranda MAG, Parés X, Farrés J, Juanhuix J. Castellví A, et al. Among authors: farres j. Sci Rep. 2019 Feb 28;9(1):3177. doi: 10.1038/s41598-019-39722-0. Sci Rep. 2019. PMID: 30816220 Free PMC article.
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