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Shigella enterotoxin 1: an enterotoxin of Shigella flexneri 2a active in rabbit small intestine in vivo and in vitro.
Fasano A, Noriega FR, Maneval DR Jr, Chanasongcram S, Russell R, Guandalini S, Levine MM. Fasano A, et al. J Clin Invest. 1995 Jun;95(6):2853-61. doi: 10.1172/JCI117991. J Clin Invest. 1995. PMID: 7769126 Free PMC article.
Also, when tested in Ussing chambers, a greater rise in potential difference and short circuit current was seen with such filtrates compared with the medium control. ...These observations suggest that S. flexneri 2a elaborates two distinct enterotoxins: ShET1, encoded by g …
Also, when tested in Ussing chambers, a greater rise in potential difference and short circuit current was seen with such filtrates c …
The synthesis of OspD3 (ShET2) in Shigella flexneri is independent of OspC1.
Faherty CS, Wu T, Morris CR, Grassel CL, Rasko DA, Harper JM, Shea-Donohue T, Fasano A, Barry EM. Faherty CS, et al. Gut Microbes. 2016 Nov;7(6):486-502. doi: 10.1080/19490976.2016.1239682. Epub 2016 Sep 22. Gut Microbes. 2016. PMID: 27657187 Free PMC article.
Previous literature has suggested that ospD3 is in an operon downstream of the ospC1 gene, and expression of both genes is controlled by a promoter upstream of ospC1. ...This work increases our understanding of the synthesis of a unique virulence factor and provides …
Previous literature has suggested that ospD3 is in an operon downstream of the ospC1 gene, and expression of both genes is controlled by …
Effect of wild-type Shigella species and attenuated Shigella vaccine candidates on small intestinal barrier function, antigen trafficking, and cytokine release.
Fiorentino M, Levine MM, Sztein MB, Fasano A. Fiorentino M, et al. PLoS One. 2014 Jan 9;9(1):e85211. doi: 10.1371/journal.pone.0085211. eCollection 2014. PLoS One. 2014. PMID: 24416363 Free PMC article.
Shigella vaccine strains elicited a pro-inflammatory response without affecting the intestinal barrier integrity. Our data show that wild-type Shigella infection causes a severe alteration of the barrier function of a small intestinal cell monolayer (a
Shigella vaccine strains elicited a pro-inflammatory response without affecting the intestinal barrier integrity. Our data show that …
Chromosomal and plasmid-encoded factors of Shigella flexneri induce secretogenic activity ex vivo.
Faherty CS, Harper JM, Shea-Donohue T, Barry EM, Kaper JB, Fasano A, Nataro JP. Faherty CS, et al. PLoS One. 2012;7(11):e49980. doi: 10.1371/journal.pone.0049980. Epub 2012 Nov 16. PLoS One. 2012. PMID: 23166804 Free PMC article.
Watery diarrhea is thought to arise in the jejunum, and subsequent bloody diarrhea occurs as a result of invasion of the colonic epithelium. ...The use of mouse jejunum serves as a reliable and reproducible model to identify the enterotoxins elaborated by enteric ba …
Watery diarrhea is thought to arise in the jejunum, and subsequent bloody diarrhea occurs as a result of invasion of the colonic epit …
Progress and pitfalls in Shigella vaccine research.
Barry EM, Pasetti MF, Sztein MB, Fasano A, Kotloff KL, Levine MM. Barry EM, et al. Nat Rev Gastroenterol Hepatol. 2013 Apr;10(4):245-55. doi: 10.1038/nrgastro.2013.12. Epub 2013 Feb 19. Nat Rev Gastroenterol Hepatol. 2013. PMID: 23419287 Free PMC article. Review.
Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure.
El Asmar R, Panigrahi P, Bamford P, Berti I, Not T, Coppa GV, Catassi C, Fasano A. El Asmar R, et al. Gastroenterology. 2002 Nov;123(5):1607-15. doi: 10.1053/gast.2002.36578. Gastroenterology. 2002. PMID: 12404235
On the basis of our recent discovery of zonulin, a modulator of small-intestinal tight junctions, we asked whether microorganisms might induce zonulin secretion and increased small-intestinal permeability. ...CONCLUSIONS: This zonulin-driven opening of the paracellular pat …
On the basis of our recent discovery of zonulin, a modulator of small-intestinal tight junctions, we asked whether microorganisms mig …
A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease.
Catassi C, Fabiani E, Iacono G, D'Agate C, Francavilla R, Biagi F, Volta U, Accomando S, Picarelli A, De Vitis I, Pianelli G, Gesuita R, Carle F, Mandolesi A, Bearzi I, Fasano A. Catassi C, et al. Am J Clin Nutr. 2007 Jan;85(1):160-6. doi: 10.1093/ajcn/85.1.160. Am J Clin Nutr. 2007. PMID: 17209192 Clinical Trial.
DESIGN: This was a multicenter, double-blind, placebo-controlled, randomized trial in 49 adults with biopsy-proven CD who were being treated with a gluten-free diet (GFD) for > or =2 y. ...After a baseline evaluation (t0), patients were assigned to ingest …
DESIGN: This was a multicenter, double-blind, placebo-controlled, randomized trial in 49 adults with biopsy-proven CD who were being …
Calcium-dependent intestinal chloride secretion by Vibrio parahaemolyticus thermostable direct hemolysin in a rabbit model.
Raimondi F, Kao JP, Kaper JB, Guandalini S, Fasano A. Raimondi F, et al. Gastroenterology. 1995 Aug;109(2):381-6. doi: 10.1016/0016-5085(95)90324-0. Gastroenterology. 1995. PMID: 7615186
In IEC-6 cells, a 10-fold increase in intracellular calcium level was found after addition of hemolysin. Such an increase was totally quenched by BAPTA. ...CONCLUSIONS: These data support the hypothesis that the thermostable direct hemolysin induces intestinal chloride sec …
In IEC-6 cells, a 10-fold increase in intracellular calcium level was found after addition of hemolysin. Such an increase was totally …
Bacterial infections: small intestine and colon.
Fasano A. Fasano A. Curr Opin Gastroenterol. 2001 Jan;17(1):4-9. doi: 10.1097/00001574-200101000-00002. Curr Opin Gastroenterol. 2001. PMID: 17031142
Bacterial enteric infections exact a heavy toll on human populations, particularly among children. Despite the explosion of knowledge on the pathogenesis of enteric diseases experienced during the past decade, the number of diarrheal episodes and human deaths reported worl …
Bacterial enteric infections exact a heavy toll on human populations, particularly among children. Despite the explosion of knowledge …
IS1414, an Escherichia coli insertion sequence with a heat-stable enterotoxin gene embedded in a transposase-like gene.
McVeigh A, Fasano A, Scott DA, Jelacic S, Moseley SL, Robertson DC, Savarino SJ. McVeigh A, et al. Infect Immun. 2000 Oct;68(10):5710-5. doi: 10.1128/iai.68.10.5710-5715.2000. Infect Immun. 2000. PMID: 10992475 Free PMC article.
A single hybridizing fragment was detected on the plasmid of ETEC strain 27D that also encodes heat-stable enterotoxin Ib and colonization factor antigen I. ...It seems to offer a most efficient mechanism for intragenomic and horizontal dissemination of EAST1....
A single hybridizing fragment was detected on the plasmid of ETEC strain 27D that also encodes heat-stable enterotoxin Ib and coloniz
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