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Fasting: molecular mechanisms and clinical applications.
Longo VD, Mattson MP. Longo VD, et al. Cell Metab. 2014 Feb 4;19(2):181-92. doi: 10.1016/j.cmet.2013.12.008. Epub 2014 Jan 16. Cell Metab. 2014. PMID: 24440038 Free PMC article. Review.
In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. ...Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic diet …
In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. ...Thus, …
Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms.
Hwangbo DS, Lee HY, Abozaid LS, Min KJ. Hwangbo DS, et al. Nutrients. 2020 Apr 24;12(4):1194. doi: 10.3390/nu12041194. Nutrients. 2020. PMID: 32344591 Free PMC article. Review.
Here, we review the history of CR and fasting-related strategies in animal models, discuss the molecular mechanisms underlying these interventions, and propose future directions that can fill the missing gaps in the current understanding of these dietary inte …
Here, we review the history of CR and fasting-related strategies in animal models, discuss the molecular mechanisms und …
Unique, Gender-Dependent Serum microRNA Profile in PLS3 Gene-Related Osteoporosis.
Mäkitie RE, Hackl M, Weigl M, Frischer A, Kämpe A, Costantini A, Grillari J, Mäkitie O. Mäkitie RE, et al. J Bone Miner Res. 2020 Oct;35(10):1962-1973. doi: 10.1002/jbmr.4097. Epub 2020 Jul 2. J Bone Miner Res. 2020. PMID: 32453450
Our study aimed to explore serum microRNA (miRNA) concentrations in subjects with defective PLS3 function to identify novel markers that could differentiate subjects according to mutation status and give insight into the molecular mechanisms by which PLS3 regulates …
Our study aimed to explore serum microRNA (miRNA) concentrations in subjects with defective PLS3 function to identify novel markers that cou …
Alteration of Liver Peroxisomal and Mitochondrial Functionality in the NZO Mouse Model of Metabolic Syndrome.
Knebel B, Göddeke S, Hartwig S, Hörbelt T, Fahlbusch P, Al-Hasani H, Jacob S, Koellmer C, Nitzgen U, Schiller M, Lehr S, Kotzka J. Knebel B, et al. Proteomics Clin Appl. 2018 Jan;12(1). doi: 10.1002/prca.201700028. Epub 2017 Dec 11. Proteomics Clin Appl. 2018. PMID: 29068532
PURPOSE: Metabolic syndrome (MetS) consists of five risk factors: elevated blood pressure and fasting glucose, visceral obesity, dyslipidemia, and hypercholesterinemia. ...We applied a multi-omics approach combining lipidomics with liver transcriptomics and top-down MS bas …
PURPOSE: Metabolic syndrome (MetS) consists of five risk factors: elevated blood pressure and fasting glucose, visceral obesity, dysl …
Effect of Hawthorn Leaf Flavonoids in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome in Rats.
Shi Y, Kong X, Yin H, Zhang W, Wang W. Shi Y, et al. Pathobiology. 2019;86(2-3):102-110. doi: 10.1159/000493895. Epub 2018 Nov 7. Pathobiology. 2019. PMID: 30404093 Free article.
OBJECTIVE: To evaluate the potential beneficial effects of hawthorn leaf flavonoids (HLF) against polycystic ovary syndrome (PCOS) in a rat model of disease and elucidate the underlying molecular mechanism. METHODS: The PCOS model was established by subcutaneous inj …
OBJECTIVE: To evaluate the potential beneficial effects of hawthorn leaf flavonoids (HLF) against polycystic ovary syndrome (PCOS) in a rat …
Liraglutide, a human glucagon-like peptide-1 analogue, stimulates AKT-dependent survival signalling and inhibits pancreatic β-cell apoptosis.
Kapodistria K, Tsilibary EP, Kotsopoulou E, Moustardas P, Kitsiou P. Kapodistria K, et al. J Cell Mol Med. 2018 Jun;22(6):2970-2980. doi: 10.1111/jcmm.13259. Epub 2018 Mar 10. J Cell Mol Med. 2018. PMID: 29524296 Free PMC article.
Apart from glucoregulatory and insulinotropic actions, liraglutide increases beta-cell mass through stimulation of beta-cell proliferation and islet neogenesis, as well as inhibition of beta-cell apoptosis. However, the underline molecular mechanisms have not been f …
Apart from glucoregulatory and insulinotropic actions, liraglutide increases beta-cell mass through stimulation of beta-cell proliferation a …