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Fasting: molecular mechanisms and clinical applications.
Longo VD, Mattson MP. Longo VD, et al. Cell Metab. 2014 Feb 4;19(2):181-92. doi: 10.1016/j.cmet.2013.12.008. Epub 2014 Jan 16. Cell Metab. 2014. PMID: 24440038 Free PMC article. Review.
In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. ...Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic diet …
In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. ...Thus, …
Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence.
Vernieri C, Ligorio F, Tripathy D, Longo VD. Vernieri C, et al. Cell Metab. 2024 Aug 6;36(8):1644-1667. doi: 10.1016/j.cmet.2024.06.014. Epub 2024 Jul 25. Cell Metab. 2024. PMID: 39059383 Review.
More recently, results of phase 1/2 clinical trials showed that cyclic FMD is safe, feasible, and associated with positive metabolic and immunomodulatory effects in patients with different tumor types, thus paving the way for larger clinical trials to investigate FM …
More recently, results of phase 1/2 clinical trials showed that cyclic FMD is safe, feasible, and associated with positive metabolic …
Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms.
Hwangbo DS, Lee HY, Abozaid LS, Min KJ. Hwangbo DS, et al. Nutrients. 2020 Apr 24;12(4):1194. doi: 10.3390/nu12041194. Nutrients. 2020. PMID: 32344591 Free PMC article. Review.
Here, we review the history of CR and fasting-related strategies in animal models, discuss the molecular mechanisms underlying these interventions, and propose future directions that can fill the missing gaps in the current understanding of these dietary inte …
Here, we review the history of CR and fasting-related strategies in animal models, discuss the molecular mechanisms und …
Intermittent fasting as a dietary intervention with potential sexually dimorphic health benefits.
Rius-Bonet J, Macip S, Closa D, Massip-Salcedo M. Rius-Bonet J, et al. Nutr Rev. 2024 May 29:nuae062. doi: 10.1093/nutrit/nuae062. Online ahead of print. Nutr Rev. 2024. PMID: 38812084
Intermittent fasting (IF) has proven to be a feasible dietary intervention for the wider population. ...Although IF may have clinical applications in different populations, studies suggest there may be sex-specific responses in parameters such as body composi …
Intermittent fasting (IF) has proven to be a feasible dietary intervention for the wider population. ...Although IF may have clini …
Alteration of Liver Peroxisomal and Mitochondrial Functionality in the NZO Mouse Model of Metabolic Syndrome.
Knebel B, Göddeke S, Hartwig S, Hörbelt T, Fahlbusch P, Al-Hasani H, Jacob S, Koellmer C, Nitzgen U, Schiller M, Lehr S, Kotzka J. Knebel B, et al. Proteomics Clin Appl. 2018 Jan;12(1). doi: 10.1002/prca.201700028. Epub 2017 Dec 11. Proteomics Clin Appl. 2018. PMID: 29068532
We applied a multi-omics approach combining lipidomics with liver transcriptomics and top-down MS based organelle proteomics (2D-DIGE) of highly enriched mitochondria and peroxisomes in male mice, to investigate molecular mechanisms related to the impact of lipid me …
We applied a multi-omics approach combining lipidomics with liver transcriptomics and top-down MS based organelle proteomics (2D-DIGE) of hi …
Interventional effects of Pueraria oral liquid on T2DM rats and metabolomics analysis.
Yang HB, Song JY, Xu C, Li J, Zhang C, Xie S, Teng CL. Yang HB, et al. Biomed Pharmacother. 2024 Jun;175:116780. doi: 10.1016/j.biopha.2024.116780. Epub 2024 May 22. Biomed Pharmacother. 2024. PMID: 38781864 Free article.
However, its mechanism of hypoglycemic effect on type 2 diabetes mellitus (T2DM) has not yet been elucidated. ...Our objective was to investigate the hypoglycemic effect of Puerarin on T2DM rats and understand its mechanism from the perspective of metabolomics. In t …
However, its mechanism of hypoglycemic effect on type 2 diabetes mellitus (T2DM) has not yet been elucidated. ...Our objective was to …
Low level of plasminogen increases risk for mortality in COVID-19 patients.
Della-Morte D, Pacifici F, Ricordi C, Massoud R, Rovella V, Proietti S, Iozzo M, Lauro D, Bernardini S, Bonassi S, Di Daniele N. Della-Morte D, et al. Cell Death Dis. 2021 Aug 5;12(8):773. doi: 10.1038/s41419-021-04070-3. Cell Death Dis. 2021. PMID: 34354045 Free PMC article.
Low levels of plasminogen were significantly associated with inflammatory markers (CRP, PCT, and IL-6), markers of coagulation (D-dimer, INR, and APTT), and markers of organ dysfunctions (high fasting blood glucose and decrease in the glomerular filtration rate). A multidi …
Low levels of plasminogen were significantly associated with inflammatory markers (CRP, PCT, and IL-6), markers of coagulation (D-dimer, INR …
Unique, Gender-Dependent Serum microRNA Profile in PLS3 Gene-Related Osteoporosis.
Mäkitie RE, Hackl M, Weigl M, Frischer A, Kämpe A, Costantini A, Grillari J, Mäkitie O. Mäkitie RE, et al. J Bone Miner Res. 2020 Oct;35(10):1962-1973. doi: 10.1002/jbmr.4097. Epub 2020 Jul 2. J Bone Miner Res. 2020. PMID: 32453450 Free article.
Our study aimed to explore serum microRNA (miRNA) concentrations in subjects with defective PLS3 function to identify novel markers that could differentiate subjects according to mutation status and give insight into the molecular mechanisms by which PLS3 regulates …
Our study aimed to explore serum microRNA (miRNA) concentrations in subjects with defective PLS3 function to identify novel markers that cou …
Effect of Hawthorn Leaf Flavonoids in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome in Rats.
Shi Y, Kong X, Yin H, Zhang W, Wang W. Shi Y, et al. Pathobiology. 2019;86(2-3):102-110. doi: 10.1159/000493895. Epub 2018 Nov 7. Pathobiology. 2019. PMID: 30404093 Free article.
Insulin resistance (IR) was calculated as HOMA-IR = fasting insulin (U/L) fasting glucose (mM)/22.5. The estrous cycle was determined by vaginal smear. ...CONCLUSION: HLF manifest protective effects against PCOS progression in the animal model, which may hold great …
Insulin resistance (IR) was calculated as HOMA-IR = fasting insulin (U/L) fasting glucose (mM)/22.5. The estrous cycle was det …
Mulberry-Derived 1-Deoxynojirimycin Prevents Type 2 Diabetes Mellitus Progression via Modulation of Retinol-Binding Protein 4 and Haptoglobin.
Fongsodsri K, Thaipitakwong T, Rujimongkon K, Kanjanapruthipong T, Ampawong S, Reamtong O, Aramwit P. Fongsodsri K, et al. Nutrients. 2022 Oct 28;14(21):4538. doi: 10.3390/nu14214538. Nutrients. 2022. PMID: 36364802 Free PMC article.
Our recent study demonstrated that mulberry leaf powder with 12 mg of DNJ improves postprandial hyperglycemia, fasting plasma glucose, and glycated hemoglobin. However, the detailed mechanisms are still unknown. ...
Our recent study demonstrated that mulberry leaf powder with 12 mg of DNJ improves postprandial hyperglycemia, fasting plasma glucose …
12 results