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Fat cells directly sense temperature to activate thermogenesis.
Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM. Ye L, et al. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12480-5. doi: 10.1073/pnas.1310261110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818608 Free PMC article.
Cold is known to act indirectly through the sympathetic nervous systems and beta-adrenergic signaling, but here we report that cool temperature (27-33 C) can directly activate a thermogenic gene program in adipocytes in a cell-autonomous manner. White …
Cold is known to act indirectly through the sympathetic nervous systems and beta-adrenergic signaling, but here we report that cool tempe
Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice.
Meyer CW, Willershäuser M, Jastroch M, Rourke BC, Fromme T, Oelkrug R, Heldmaier G, Klingenspor M. Meyer CW, et al. Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1396-406. doi: 10.1152/ajpregu.00021.2009. Epub 2010 Sep 8. Am J Physiol Regul Integr Comp Physiol. 2010. PMID: 20826705 Free PMC article.
As judged from respiratory quotients, acutely cold-challenged UCP1-KO mice showed a delayed transition toward lipid oxidation, and 5-h cold exposure revealed diminished physical activity and less variability in the control of metabolic rate. We conclude that BAT is require …
As judged from respiratory quotients, acutely cold-challenged UCP1-KO mice showed a delayed transition toward lipid oxidation, and 5-h cold …