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CDK inhibition and cancer therapy.
Garrett MD, Fattaey A. Garrett MD, et al. Among authors: fattaey a. Curr Opin Genet Dev. 1999 Feb;9(1):104-11. doi: 10.1016/s0959-437x(99)80015-x. Curr Opin Genet Dev. 1999. PMID: 10072351 Review.
New functional activities for the p21 family of CDK inhibitors.
LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E. LaBaer J, et al. Among authors: fattaey a. Genes Dev. 1997 Apr 1;11(7):847-62. doi: 10.1101/gad.11.7.847. Genes Dev. 1997. PMID: 9106657 Free article.
Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14.
Fattaey A, Booher RN. Fattaey A, et al. Prog Cell Cycle Res. 1997;3:233-40. doi: 10.1007/978-1-4615-5371-7_18. Prog Cell Cycle Res. 1997. PMID: 9552418 Review.
Most somatic cell division cycles contain a gap period (G2 phase) between the completion of DNA synthesis and the initiation of mitosis. ...
Most somatic cell division cycles contain a gap period (G2 phase) between the completion of DNA synthesis and the initiation of mitos …
Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity.
Booher RN, Holman PS, Fattaey A. Booher RN, et al. Among authors: fattaey a. J Biol Chem. 1997 Aug 29;272(35):22300-6. doi: 10.1074/jbc.272.35.22300. J Biol Chem. 1997. PMID: 9268380 Free article.
Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents.
Johnson L, Shen A, Boyle L, Kunich J, Pandey K, Lemmon M, Hermiston T, Giedlin M, McCormick F, Fattaey A. Johnson L, et al. Among authors: fattaey a. Cancer Cell. 2002 May;1(4):325-37. doi: 10.1016/s1535-6108(02)00060-0. Cancer Cell. 2002. PMID: 12086848 Free article.
Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.
Barvian M, Boschelli DH, Cossrow J, Dobrusin E, Fattaey A, Fritsch A, Fry D, Harvey P, Keller P, Garrett M, La F, Leopold W, McNamara D, Quin M, Trumpp-Kallmeyer S, Toogood P, Wu Z, Zhang E. Barvian M, et al. Among authors: fattaey a. J Med Chem. 2000 Nov 30;43(24):4606-16. doi: 10.1021/jm000271k. J Med Chem. 2000. PMID: 11101352
Characterization of the retinoblastoma binding proteins RBP1 and RBP2.
Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D, et al. Fattaey AR, et al. Oncogene. 1993 Nov;8(11):3149-56. Oncogene. 1993. PMID: 8414517
Several cellular proteins have been shown to bind directly to pRB and the genes encoding a number of them have been isolated. ...The products of the RBP1 and RBP2 genes are ubiquitously expressed, large (200 kDa for RBP1 and 195 kDa for RBP2) nuclear phosphoproteins with s …
Several cellular proteins have been shown to bind directly to pRB and the genes encoding a number of them have been isolated. ...The …
Cell cycle and biochemical effects of PD 0183812. A potent inhibitor of the cyclin D-dependent kinases CDK4 and CDK6.
Fry DW, Bedford DC, Harvey PH, Fritsch A, Keller PR, Wu Z, Dobrusin E, Leopold WR, Fattaey A, Garrett MD. Fry DW, et al. Among authors: fattaey a. J Biol Chem. 2001 May 18;276(20):16617-23. doi: 10.1074/jbc.M008867200. Epub 2001 Feb 6. J Biol Chem. 2001. PMID: 11278443 Free article.
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells.
Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M, Ng L, Nye JA, Sampson-Johannes A, Fattaey A, McCormick F. Bischoff JR, et al. Science. 1996 Oct 18;274(5286):373-6. doi: 10.1126/science.274.5286.373. Science. 1996. PMID: 8832876
The human adenovirus E1B gene encodes a 55-kilodalton protein that inactivates the cellular tumor suppressor protein p53. Here it is shown that a mutant adenovirus that does not express this viral protein can replicate in and lyse p53-deficient human tumor cells but …
The human adenovirus E1B gene encodes a 55-kilodalton protein that inactivates the cellular tumor suppressor protein p53. Here it is …
Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.
Vidal M, Brachmann RK, Fattaey A, Harlow E, Boeke JD. Vidal M, et al. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10315-20. doi: 10.1073/pnas.93.19.10315. Proc Natl Acad Sci U S A. 1996. PMID: 8816797 Free PMC article.
We have engineered yeast strains in which the interaction of two proteins expressed in the context of the two-hybrid system or the interaction between a DNA-binding protein and its binding site in the context of the one-hybrid system is deleterious to growth. Under these c …
We have engineered yeast strains in which the interaction of two proteins expressed in the context of the two-hybrid system or the interacti …
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