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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1975 1
1977 1
1978 1
1980 1
1981 1
1984 2
1986 1
1992 1
1993 1
1996 2
1997 3
1998 2
1999 1
2000 3
2001 3
2002 6
2003 11
2004 5
2005 11
2006 9
2007 6
2008 6
2009 8
2010 8
2011 14
2012 11
2013 14
2014 10
2015 7
2016 12
2017 10
2018 13
2019 6
2020 3
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179 results
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Page 1
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.
Gerber PA, Rutter GA. Gerber PA, et al. Antioxid Redox Signal. 2017 Apr 1;26(10):501-518. doi: 10.1089/ars.2016.6755. Epub 2016 Jun 30. Antioxid Redox Signal. 2017. PMID: 27225690 Free PMC article. Review.
Recent Advances: Oversupply of nutrients, including glucose and fatty acids, and the subsequent overstimulation of beta cells, are believed to be an important contributor to insulin secretory failure in T2D. ...CRITICAL ISSUES: Not all subjects with …
Recent Advances: Oversupply of nutrients, including glucose and fatty acids, and the subsequent overstimulation of beta …
Non-Alcoholic Fatty Pancreas Disease (NAFPD): A Silent Spectator or the Fifth Component of Metabolic Syndrome? A Literature Review.
Romana BS, Chela H, Dailey FE, Nassir F, Tahan V. Romana BS, et al. Endocr Metab Immune Disord Drug Targets. 2018;18(6):547-554. doi: 10.2174/1871530318666180328111302. Endocr Metab Immune Disord Drug Targets. 2018. PMID: 29595117 Review.
Chronic exposure of β-cells to hyperglycemia and higher levels of free fatty acids results in increased intracellular triglyceride accumulation, which ultimately causes reduced insulin secretion, insulin resistance, cell apoptosis and subsequent …
Chronic exposure of β-cells to hyperglycemia and higher levels of free fatty acids results in increased intracellular t …
The Vasculature in Prediabetes.
Wasserman DH, Wang TJ, Brown NJ. Wasserman DH, et al. Circ Res. 2018 Apr 13;122(8):1135-1150. doi: 10.1161/CIRCRESAHA.118.311912. Circ Res. 2018. PMID: 29650631 Free PMC article. Review.
In prediabetes, hyperglycemia, insulin resistance, and inflammation and metabolic derangements associated with concomitant obesity cause endothelial vasodilator and fibrinolytic dysfunction, leading to increased risk of cardiovascular and renal disease. Impor …
In prediabetes, hyperglycemia, insulin resistance, and inflammation and metabolic derangements associated with concomit …
Protection against the Metabolic Syndrome by Guar Gum-Derived Short-Chain Fatty Acids Depends on Peroxisome Proliferator-Activated Receptor γ and Glucagon-Like Peptide-1.
den Besten G, Gerding A, van Dijk TH, Ciapaite J, Bleeker A, van Eunen K, Havinga R, Groen AK, Reijngoud DJ, Bakker BM. den Besten G, et al. PLoS One. 2015 Aug 20;10(8):e0136364. doi: 10.1371/journal.pone.0136364. eCollection 2015. PLoS One. 2015. PMID: 26292284 Free PMC article.
The major products of colonic fermentation of dietary fiber, the short-chain fatty acids (SCFAs), have been suggested to play an important role. ...In this study we investigated the molecular mechanism via which the dietary fiber guar gum protects against the met
The major products of colonic fermentation of dietary fiber, the short-chain fatty acids (SCFAs), have been suggested to play …
Zonation of glucose and fatty acid metabolism in the liver: mechanism and metabolic consequences.
Hijmans BS, Grefhorst A, Oosterveer MH, Groen AK. Hijmans BS, et al. Biochimie. 2014 Jan;96:121-9. doi: 10.1016/j.biochi.2013.06.007. Epub 2013 Jun 20. Biochimie. 2014. PMID: 23792151 Review.
The metabolic syndrome is characterized by the inability of insulin to adequately suppress hepatic gluconeogenesis, leading to hyperglycemia, hyperinsulinemia and eventually to type II diabetes. ...These observations suggest the co-existence of insu
The metabolic syndrome is characterized by the inability of insulin to adequately suppress hepatic gluconeogenesis, lea …
[THE UNESTERIFIED FATTY ACIDS IN BLOOD PLASMA AND INTERCELLULAR MEDIUM: EFFECT OF INSULIN AND ALBUMIN (THE LECTURE)].
Titov VN, Shoibonov BB. Titov VN, et al. Klin Lab Diagn. 2016 Feb;61(2):93-101. Klin Lab Diagn. 2016. PMID: 27455563 Russian.
Increasing of content of unesterifed fatty acids in blood plasma, as it always occurs in vivo, stops absorption of glucose by cells initiating hyperglycemia, hyperinsulinemia, and syndrome of resistance to insulin. ...The biological role …
Increasing of content of unesterifed fatty acids in blood plasma, as it always occurs in vivo, stops absorption of glucose
Trafficking of nonesterified fatty acids in insulin resistance and relationship to dysglycemia.
Walker RE, Ford JL, Boston RC, Savinova OV, Harris WS, Green MH, Shearer GC. Walker RE, et al. Am J Physiol Endocrinol Metab. 2020 Mar 1;318(3):E392-E404. doi: 10.1152/ajpendo.00331.2019. Epub 2020 Jan 7. Am J Physiol Endocrinol Metab. 2020. PMID: 31910030 Clinical Trial.
We used total NEFA and individual fatty acids in the NEFA MM, comparing the model parameters in metabolic syndrome (MetSyn) subjects (n = 52) with optimally healthy controls (OptHC; n = 14). ...Using the glucose MM, MetSyn subjects had lower [-7 …
We used total NEFA and individual fatty acids in the NEFA MM, comparing the model parameters in metabolic syndrome
Metabolic consequences of hyperglycemia and insulin resistance.
Jellinger PS. Jellinger PS. Clin Cornerstone. 2007;8 Suppl 7:S30-42. doi: 10.1016/s1098-3597(07)80019-6. Clin Cornerstone. 2007. PMID: 18154189 Review.
Other metabolic effects of insulin include inhibition of glucose release from the liver, inhibition of the release of free fatty acids (FFAs) from adipose tissue, and stimulation of the process by which amino acids are incorporated into p …
Other metabolic effects of insulin include inhibition of glucose release from the liver, inhibition of the release of f …
Hepatic insulin resistance, metabolic syndrome and cardiovascular disease.
Meshkani R, Adeli K. Meshkani R, et al. Clin Biochem. 2009 Sep;42(13-14):1331-46. doi: 10.1016/j.clinbiochem.2009.05.018. Epub 2009 Jun 6. Clin Biochem. 2009. PMID: 19501581 Review.
BACKGROUND: The metabolic syndrome is a constellation of common metabolic disorders that is associated with cardiovascular disease. ...Hepatic insulin resistance in turn causes impaired suppression of glucose production by insulin in hepa …
BACKGROUND: The metabolic syndrome is a constellation of common metabolic disorders that is associated with cardiovascu …
Insulin resistance in obesity as the underlying cause for the metabolic syndrome.
Gallagher EJ, Leroith D, Karnieli E. Gallagher EJ, et al. Mt Sinai J Med. 2010 Sep-Oct;77(5):511-23. doi: 10.1002/msj.20212. Mt Sinai J Med. 2010. PMID: 20960553 Review.
Many factors contribute to this syndrome, including decreased physical activity, genetic predisposition, chronic inflammation, free fatty acids, and mitochondrial dysfunction. ...Increased production of free fatty acids, inflammatory cytokines, …
Many factors contribute to this syndrome, including decreased physical activity, genetic predisposition, chronic inflammation, free …
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