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Butyl 2-(4-[1.1'-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain.
Liberatore AM, Schulz J, Favre-Guilmard C, Pommier J, Lannoy J, Pawlowski E, Barthelemy MA, Huchet M, Auguet M, Chabrier PE, Bigg D. Liberatore AM, et al. Among authors: favre guilmard c. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1746-9. doi: 10.1016/j.bmcl.2006.12.064. Epub 2006 Dec 22. Bioorg Med Chem Lett. 2007. PMID: 17234409
A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo.
Donald S, Elliott M, Gray B, Hornby F, Lewandowska A, Marlin S, Favre-Guilmard C, Périer C, Cornet S, Kalinichev M, Krupp J, Fonfria E. Donald S, et al. Among authors: favre guilmard c. Pharmacol Res Perspect. 2018 Nov 22;6(6):e00446. doi: 10.1002/prp2.446. eCollection 2018 Dec. Pharmacol Res Perspect. 2018. PMID: 30519475 Free PMC article.
Recombinant botulinum neurotoxin serotype A1 in vivo characterization.
Périer C, Martin V, Cornet S, Favre-Guilmard C, Rocher MN, Bindler J, Wagner S, Andriambeloson E, Rudkin B, Marty R, Vignaud A, Beard M, Lezmi S, Kalinichev M. Périer C, et al. Among authors: favre guilmard c. Pharmacol Res Perspect. 2021 Oct;9(5):e00857. doi: 10.1002/prp2.857. Pharmacol Res Perspect. 2021. PMID: 34632725 Free PMC article.
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, Zhang S, Dong M, Stenmark P, Krupp J. Elliott M, et al. Among authors: favre guilmard c. Sci Adv. 2019 Jan 16;5(1):eaau7196. doi: 10.1126/sciadv.aau7196. eCollection 2019 Jan. Sci Adv. 2019. PMID: 30746458 Free PMC article.