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Overcoming apoptosis deficiency of melanoma-hope for new therapeutic approaches.
Eberle J, Kurbanov BM, Hossini AM, Trefzer U, Fecker LF. Eberle J, et al. Among authors: fecker lf. Drug Resist Updat. 2007 Dec;10(6):218-34. doi: 10.1016/j.drup.2007.09.001. Epub 2007 Dec 3. Drug Resist Updat. 2007. PMID: 18054518 Review.
Activation of mitochondrial apoptosis pathways in cutaneous squamous cell carcinoma cells by diclofenac/hyaluronic acid is related to upregulation of Bad as well as downregulation of Mcl-1 and Bcl-w.
Rodust PM, Fecker LF, Stockfleth E, Eberle J. Rodust PM, et al. Among authors: fecker lf. Exp Dermatol. 2012 Jul;21(7):520-5. doi: 10.1111/j.1600-0625.2012.01516.x. Exp Dermatol. 2012. PMID: 22716247
Apoptosis induction by SAHA in cutaneous T-cell lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling.
Al-Yacoub N, Fecker LF, Möbs M, Plötz M, Braun FK, Sterry W, Eberle J. Al-Yacoub N, et al. Among authors: fecker lf. J Invest Dermatol. 2012 Sep;132(9):2263-74. doi: 10.1038/jid.2012.125. Epub 2012 May 3. J Invest Dermatol. 2012. PMID: 22551975 Free article.
Efficient melanoma cell killing and reduced melanoma growth in mice by a selective replicating adenovirus armed with tumor necrosis factor-related apoptosis-inducing ligand.
Fecker LF, Rückert S, Kurbanov BM, Schmude M, Stockfleth E, Fechner H, Eberle J. Fecker LF, et al. Hum Gene Ther. 2011 Apr;22(4):405-17. doi: 10.1089/hum.2010.108. Epub 2011 Feb 16. Hum Gene Ther. 2011. PMID: 20977303
Enhanced death ligand-induced apoptosis in cutaneous SCC cells by treatment with diclofenac/hyaluronic acid correlates with downregulation of c-FLIP.
Fecker LF, Stockfleth E, Braun FK, Rodust PM, Schwarz C, Köhler A, Leverkus M, Eberle J. Fecker LF, et al. J Invest Dermatol. 2010 Aug;130(8):2098-109. doi: 10.1038/jid.2010.40. Epub 2010 Mar 18. J Invest Dermatol. 2010. PMID: 20237495 Free article.
Efficient and selective tumor cell lysis and induction of apoptosis in melanoma cells by a conditional replication-competent CD95L adenovirus.
Fecker LF, Schmude M, Jost S, Hossini AM, Picó AH, Wang X, Schwarz C, Fechner H, Eberle J. Fecker LF, et al. Exp Dermatol. 2010 Aug;19(8):e56-66. doi: 10.1111/j.1600-0625.2009.00977.x. Exp Dermatol. 2010. PMID: 19725869 Free article.
Apoptosis pathways and oncolytic adenoviral vectors: promising targets and tools to overcome therapy resistance of malignant melanoma.
Eberle J, Fecker LF, Hossini AM, Kurbanov BM, Fechner H. Eberle J, et al. Among authors: fecker lf. Exp Dermatol. 2008 Jan;17(1):1-11. doi: 10.1111/j.1600-0625.2007.00655.x. Exp Dermatol. 2008. PMID: 18095940 Review.
Blockade of death receptor-mediated pathways early in the signaling cascade coincides with distinct apoptosis resistance in cutaneous T-cell lymphoma cells.
Braun FK, Fecker LF, Schwarz C, Walden P, Assaf C, Dürkop H, Sterry W, Eberle J. Braun FK, et al. Among authors: fecker lf. J Invest Dermatol. 2007 Oct;127(10):2425-37. doi: 10.1038/sj.jid.5700868. Epub 2007 May 10. J Invest Dermatol. 2007. PMID: 17495957 Free article.
Loss of proapoptotic Bcl-2-related multidomain proteins in primary melanomas is associated with poor prognosis.
Fecker LF, Geilen CC, Tchernev G, Trefzer U, Assaf C, Kurbanov BM, Schwarz C, Daniel PT, Eberle J. Fecker LF, et al. J Invest Dermatol. 2006 Jun;126(6):1366-71. doi: 10.1038/sj.jid.5700192. J Invest Dermatol. 2006. PMID: 16528364
Efficient TRAIL-R1/DR4-mediated apoptosis in melanoma cells by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Kurbanov BM, Geilen CC, Fecker LF, Orfanos CE, Eberle J. Kurbanov BM, et al. Among authors: fecker lf. J Invest Dermatol. 2005 Nov;125(5):1010-9. doi: 10.1111/j.0022-202X.2005.23900.x. J Invest Dermatol. 2005. PMID: 16297203
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