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Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M. Ingram JR, et al. Among authors: fedorov aa, fedorov e. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3912-3917. doi: 10.1073/pnas.1801524115. Epub 2018 Mar 26. Proc Natl Acad Sci U S A. 2018. PMID: 29581255 Free PMC article.
Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family.
Odokonyero D, Sakai A, Patskovsky Y, Malashkevich VN, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Agarwal R, Wang C, Ozerova ND, Yew WS, Sauder JM, Swaminathan S, Burley SK, Almo SC, Glasner ME. Odokonyero D, et al. Among authors: fedorov ev, fedorov aa. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8535-40. doi: 10.1073/pnas.1318703111. Epub 2014 May 28. Proc Natl Acad Sci U S A. 2014. PMID: 24872444 Free PMC article.
Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex.
Garrett-Thomson SC, Massimi A, Fedorov EV, Bonanno JB, Scandiuzzi L, Hillerich B, Seidel RD 3rd, Love JD, Garforth SJ, Guha C, Almo SC. Garrett-Thomson SC, et al. PLoS One. 2020 Jun 4;15(6):e0233578. doi: 10.1371/journal.pone.0233578. eCollection 2020. PLoS One. 2020. PMID: 32497097 Free PMC article.
Structure of CD84 provides insight into SLAM family function.
Yan Q, Malashkevich VN, Fedorov A, Fedorov E, Cao E, Lary JW, Cole JL, Nathenson SG, Almo SC. Yan Q, et al. Among authors: fedorov e, fedorov a. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10583-8. doi: 10.1073/pnas.0703893104. Epub 2007 Jun 11. Proc Natl Acad Sci U S A. 2007. PMID: 17563375 Free PMC article.
Structural Basis of CD160:HVEM Recognition.
Liu W, Garrett SC, Fedorov EV, Ramagopal UA, Garforth SJ, Bonanno JB, Almo SC. Liu W, et al. Structure. 2019 Aug 6;27(8):1286-1295.e4. doi: 10.1016/j.str.2019.05.010. Epub 2019 Jun 20. Structure. 2019. PMID: 31230945 Free PMC article.
HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
Liu W, Chou TF, Garrett-Thomson SC, Seo GY, Fedorov E, Ramagopal UA, Bonanno JB, Wang Q, Kim K, Garforth SJ, Kakugawa K, Cheroutre H, Kronenberg M, Almo SC. Liu W, et al. Among authors: fedorov e. J Exp Med. 2021 Dec 6;218(12):e20211112. doi: 10.1084/jem.20211112. Epub 2021 Oct 28. J Exp Med. 2021. PMID: 34709351 Free PMC article.
Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily.
Lukk T, Sakai A, Kalyanaraman C, Brown SD, Imker HJ, Song L, Fedorov AA, Fedorov EV, Toro R, Hillerich B, Seidel R, Patskovsky Y, Vetting MW, Nair SK, Babbitt PC, Almo SC, Gerlt JA, Jacobson MP. Lukk T, et al. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4122-7. doi: 10.1073/pnas.1112081109. Epub 2012 Mar 5. Proc Natl Acad Sci U S A. 2012. PMID: 22392983 Free PMC article.
214 results