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T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.
Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S. Ohkura N, et al. Among authors: fehling hj. Immunity. 2012 Nov 16;37(5):785-99. doi: 10.1016/j.immuni.2012.09.010. Epub 2012 Nov 1. Immunity. 2012. PMID: 23123060
Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.
Krotkova A, von Boehmer H, Fehling HJ. Krotkova A, et al. Among authors: fehling hj. J Exp Med. 1997 Aug 29;186(5):767-75. doi: 10.1084/jem.186.5.767. J Exp Med. 1997. PMID: 9271592 Free PMC article.
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