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Hyperforin induces Ca(2+)-independent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A(2) activation through select phospholipid interactions.
Hoffmann M, Lopez JJ, Pergola C, Feisst C, Pawelczik S, Jakobsson PJ, Sorg BL, Glaubitz C, Steinhilber D, Werz O. Hoffmann M, et al. Among authors: feisst c. Biochim Biophys Acta. 2010 Apr;1801(4):462-72. doi: 10.1016/j.bbalip.2009.12.007. Epub 2009 Dec 28. Biochim Biophys Acta. 2010. PMID: 20044029
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.
Feisst C, Pergola C, Rakonjac M, Rossi A, Koeberle A, Dodt G, Hoffmann M, Hoernig C, Fischer L, Steinhilber D, Franke L, Schneider G, Rådmark O, Sautebin L, Werz O. Feisst C, et al. Cell Mol Life Sci. 2009 Aug;66(16):2759-71. doi: 10.1007/s00018-009-0078-3. Epub 2009 Jul 5. Cell Mol Life Sci. 2009. PMID: 19579006