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The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity.
Camnasio S, Delli Carri A, Lombardo A, Grad I, Mariotti C, Castucci A, Rozell B, Lo Riso P, Castiglioni V, Zuccato C, Rochon C, Takashima Y, Diaferia G, Biunno I, Gellera C, Jaconi M, Smith A, Hovatta O, Naldini L, Di Donato S, Feki A, Cattaneo E. Camnasio S, et al. Among authors: feki a. Neurobiol Dis. 2012 Apr;46(1):41-51. doi: 10.1016/j.nbd.2011.12.042. Neurobiol Dis. 2012. PMID: 22405424
NANOG priming before full reprogramming may generate germ cell tumours.
Grad I, Hibaoui Y, Jaconi M, Chicha L, Bergström-Tengzelius R, Sailani MR, Pelte MF, Dahoun S, Mitsiadis TA, Töhönen V, Bouillaguet S, Antonarakis SE, Kere J, Zucchelli M, Hovatta O, Feki A. Grad I, et al. Among authors: feki a. Eur Cell Mater. 2011 Nov 9;22:258-74; discussio 274. doi: 10.22203/ecm.v022a20. Eur Cell Mater. 2011. PMID: 22071697
Pluripotent stem cells as new drugs? The example of Parkinson's disease.
Preynat-Seauve O, Burkhard PR, Villard J, Zingg W, Ginovart N, Feki A, Dubois-Dauphin M, Hurst SA, Mauron A, Jaconi M, Krause KH. Preynat-Seauve O, et al. Among authors: feki a. Int J Pharm. 2009 Nov 3;381(2):113-21. doi: 10.1016/j.ijpharm.2009.03.003. Epub 2009 Mar 19. Int J Pharm. 2009. PMID: 19782880 Review.
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