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Proliferation of human malignant astrocytomas is dependent on Ras activation.
Guha A, Feldkamp MM, Lau N, Boss G, Pawson A. Guha A, et al. Among authors: feldkamp mm. Oncogene. 1997 Dec 4;15(23):2755-65. doi: 10.1038/sj.onc.1201455. Oncogene. 1997. PMID: 9419966
Aberrant G protein signaling in nervous system tumors.
Woods SA, Marmor E, Feldkamp M, Lau N, Apicelli AJ, Boss G, Gutmann DH, Guha A. Woods SA, et al. Among authors: feldkamp m. J Neurosurg. 2002 Sep;97(3):627-42. doi: 10.3171/jns.2002.97.3.0627. J Neurosurg. 2002. PMID: 12296648 Review.
Isotype-specific Ras.GTP-levels predict the efficacy of farnesyl transferase inhibitors against human astrocytomas regardless of Ras mutational status.
Feldkamp MM, Lau N, Roncari L, Guha A. Feldkamp MM, et al. Cancer Res. 2001 Jun 1;61(11):4425-31. Cancer Res. 2001. PMID: 11389071 Free article.
Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma.
Lau N, Feldkamp MM, Roncari L, Loehr AH, Shannon P, Gutmann DH, Guha A. Lau N, et al. Among authors: feldkamp mm. J Neuropathol Exp Neurol. 2000 Sep;59(9):759-67. doi: 10.1093/jnen/59.9.759. J Neuropathol Exp Neurol. 2000. PMID: 11005256
The farnesyltransferase inhibitor L-744,832 inhibits the growth of astrocytomas through a combination of antiproliferative, antiangiogenic, and proapoptotic activities.
Feldkamp MM, Lau N, Guha A. Feldkamp MM, et al. Ann N Y Acad Sci. 1999;886:257-60. doi: 10.1111/j.1749-6632.1999.tb09430.x. Ann N Y Acad Sci. 1999. PMID: 10667233 No abstract available.
Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.
Feldkamp MM, Lau N, Guha A. Feldkamp MM, et al. Oncogene. 1999 Dec 9;18(52):7514-26. doi: 10.1038/sj.onc.1203105. Oncogene. 1999. PMID: 10602510 Free article.
Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens.
Feldkamp MM, Lala P, Lau N, Roncari L, Guha A. Feldkamp MM, et al. Neurosurgery. 1999 Dec;45(6):1442-53. doi: 10.1097/00006123-199912000-00034. Neurosurgery. 1999. PMID: 10598712
Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras.
Feldkamp MM, Lau N, Rak J, Kerbel RS, Guha A. Feldkamp MM, et al. Int J Cancer. 1999 Mar 31;81(1):118-24. doi: 10.1002/(sici)1097-0215(19990331)81:1<118::aid-ijc20>;2-5. Int J Cancer. 1999. PMID: 10077162 Free article.
Neurofibromatosis type 1 peripheral nerve tumors: aberrant activation of the Ras pathway.
Feldkamp MM, Angelov L, Guha A. Feldkamp MM, et al. Surg Neurol. 1999 Feb;51(2):211-8. doi: 10.1016/s0090-3019(97)00356-x. Surg Neurol. 1999. PMID: 10029430
Neurofibromatosis type 1: piecing the puzzle together.
Feldkamp MM, Gutmann DH, Guha A. Feldkamp MM, et al. Can J Neurol Sci. 1998 Aug;25(3):181-91. doi: 10.1017/s0317167100033990. Can J Neurol Sci. 1998. PMID: 9706718 Review.
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