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Nitric oxide: a new paradigm for second messengers.
Kerwin JF Jr, Lancaster JR Jr, Feldman PL. Kerwin JF Jr, et al. J Med Chem. 1995 Oct 27;38(22):4343-62. doi: 10.1021/jm00022a001. J Med Chem. 1995. PMID: 7473563 Review. No abstract available.
Control of electron transfer in neuronal nitric oxide synthase by calmodulin, substrate, substrate analogs, and nitric oxide.
Stuehr DJ, Abu-Soud HM, Rousseau DL, Feldman PL, Wang J. Stuehr DJ, et al. Adv Pharmacol. 1995;34:207-13. doi: 10.1016/s1054-3589(08)61087-x. Adv Pharmacol. 1995. PMID: 8562435 Review. No abstract available.
Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase.
Brackeen MF, Cowan DJ, Stafford JA, Schoenen FJ, Veal JM, Domanico PL, Rose D, Strickland AB, Verghese M, Feldman PL. Brackeen MF, et al. J Med Chem. 1995 Nov 24;38(24):4848-54. doi: 10.1021/jm00024a012. J Med Chem. 1995. PMID: 7490734
Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of (R*,R*)-(+/-)-methyl 3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase.
Stafford JA, Veal JM, Feldman PL, Valvano NL, Baer PG, Brackeen MF, Brawley ES, Connolly KM, Domanico PL, Han B, et al. Stafford JA, et al. J Med Chem. 1995 Dec 22;38(26):4972-5. doi: 10.1021/jm00026a003. J Med Chem. 1995. PMID: 8544172 No abstract available.
Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes.
Wu Y, Aquino CJ, Cowan DJ, Anderson DL, Ambroso JL, Bishop MJ, Boros EE, Chen L, Cunningham A, Dobbins RL, Feldman PL, Harston LT, Kaldor IW, Klein R, Liang X, McIntyre MS, Merrill CL, Patterson KM, Prescott JS, Ray JS, Roller SG, Yao X, Young A, Yuen J, Collins JL. Wu Y, et al. Among authors: feldman pl. J Med Chem. 2013 Jun 27;56(12):5094-114. doi: 10.1021/jm400459m. Epub 2013 Jun 6. J Med Chem. 2013. PMID: 23678871
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