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Circuit mechanisms underlying embryonic retinal waves.
Voufo C, Chen AQ, Smith BE, Yan R, Feller MB, Tiriac A. Voufo C, et al. Elife. 2023 Feb 15;12:e81983. doi: 10.7554/eLife.81983. Elife. 2023. PMID: 36790167 Free PMC article.
To assay the impact of stage 1 waves on retinal development, we compared the spatial distribution of a subtype of retinal ganglion cells, intrinsically photosensitive retinal ganglion cells (ipRGCs), which undergo a significant amount of cell death, in WT and beta2- …
To assay the impact of stage 1 waves on retinal development, we compared the spatial distribution of a subtype of retinal ganglion cells …
Targeted Protein Degradation of Histone Deacetylases by Hydrophobically Tagged Inhibitors.
Feller F, Hansen FK. Feller F, et al. ACS Med Chem Lett. 2023 Nov 15;14(12):1863-1868. doi: 10.1021/acsmedchemlett.3c00468. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116436 Free PMC article.
The subsequent biological evaluation led to the identification of our best degrader, 1a, which significantly decreased HDAC1 levels in MM.1S multiple myeloma cells....
The subsequent biological evaluation led to the identification of our best degrader, 1a, which significantly decreased HDAC1 levels in MM.1S …
A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions.
Detraux D, Caruso M, Feller L, Fransolet M, Meurant S, Mathieu J, Arnould T, Renard P. Detraux D, et al. Elife. 2023 Jul 10;12:e78546. doi: 10.7554/eLife.78546. Elife. 2023. PMID: 37428012 Free PMC article.
Using embryonic stem cells (ESCs) in regenerative medicine or in disease modeling requires a complete understanding of these cells. ...In addition, heme synthesis inhibition promotes the acquisition of 2 cell-like cells in a heme-independent manner caused by …
Using embryonic stem cells (ESCs) in regenerative medicine or in disease modeling requires a complete understanding of these cells …