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Circuit mechanisms underlying embryonic retinal waves.
Voufo C, Chen AQ, Smith BE, Yan R, Feller MB, Tiriac A. Voufo C, et al. Elife. 2023 Feb 15;12:e81983. doi: 10.7554/eLife.81983. Elife. 2023. PMID: 36790167 Free PMC article.
To assay the impact of stage 1 waves on retinal development, we compared the spatial distribution of a subtype of retinal ganglion cells, intrinsically photosensitive retinal ganglion cells (ipRGCs), which undergo a significant amount of cell death, in WT and beta2- …
To assay the impact of stage 1 waves on retinal development, we compared the spatial distribution of a subtype of retinal ganglion cells …
Cardiac Rhabdomyoma in Four Göttingen Minipigs.
Feller LE, Sargeant A, Ehrhart EJ, Balmer B, Nelson K, Lamoureux J. Feller LE, et al. Toxicol Pathol. 2023 Jan;51(1-2):61-66. doi: 10.1177/01926233221148393. Epub 2023 Feb 1. Toxicol Pathol. 2023. PMID: 36726336
In all cases, microscopic evaluation revealed well-circumscribed, expansile nodules composed of bundles of large, highly vacuolated, ovoid to polygonal cells with variable cytoplasmic processes radiating from a centrally located nucleus. Cells displayed patchy accum …
In all cases, microscopic evaluation revealed well-circumscribed, expansile nodules composed of bundles of large, highly vacuolated, ovoid t …
Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors.
Bachmann LM, Hanl M, Feller F, Sinatra L, Schöler A, Pietzsch J, Laube M, Hansen FK. Bachmann LM, et al. Molecules. 2023 Jan 20;28(3):1061. doi: 10.3390/molecules28031061. Molecules. 2023. PMID: 36770730 Free PMC article.
The most promising dual inhibitors, C3 and C4, evoked antiproliferative effects in the low micromolar concentration range and caused a significant increase in apoptotic cells. In contrast to previous reports, the simultaneous inhibition of HDAC and COX activity by dual HDA …
The most promising dual inhibitors, C3 and C4, evoked antiproliferative effects in the low micromolar concentration range and caused a signi …
A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions.
Detraux D, Caruso M, Feller L, Fransolet M, Meurant S, Mathieu J, Arnould T, Renard P. Detraux D, et al. Elife. 2023 Jul 10;12:e78546. doi: 10.7554/eLife.78546. Elife. 2023. PMID: 37428012 Free PMC article.
Using embryonic stem cells (ESCs) in regenerative medicine or in disease modeling requires a complete understanding of these cells. ...In addition, heme synthesis inhibition promotes the acquisition of 2 cell-like cells in a heme-independent manner caused by …
Using embryonic stem cells (ESCs) in regenerative medicine or in disease modeling requires a complete understanding of these cells …
Targeted Protein Degradation of Histone Deacetylases by Hydrophobically Tagged Inhibitors.
Feller F, Hansen FK. Feller F, et al. ACS Med Chem Lett. 2023 Nov 15;14(12):1863-1868. doi: 10.1021/acsmedchemlett.3c00468. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116436 Free PMC article.
The subsequent biological evaluation led to the identification of our best degrader, 1a, which significantly decreased HDAC1 levels in MM.1S multiple myeloma cells....
The subsequent biological evaluation led to the identification of our best degrader, 1a, which significantly decreased HDAC1 levels in MM.1S …