Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1958 1
1960 1
1961 1
1964 2
1965 4
1966 7
1967 12
1968 11
1969 38
1970 24
1971 40
1972 60
1973 93
1974 57
1975 114
1976 54
1977 68
1978 57
1979 67
1980 58
1981 63
1982 71
1983 62
1984 59
1985 65
1986 90
1987 58
1988 100
1989 95
1990 98
1991 85
1992 165
1993 126
1994 109
1995 126
1996 165
1997 183
1998 180
1999 147
2000 131
2001 97
2002 107
2003 88
2004 66
2005 65
2006 61
2007 59
2008 48
2009 50
2010 62
2011 70
2012 48
2013 45
2014 32
2015 30
2016 28
2017 31
2018 29
2019 31
2020 27
2021 51
2022 56
2023 39
2024 18

Text availability

Article attribute

Article type

Publication date

Search Results

4,053 results

Results by year

Filters applied: . Clear all
Page 1
Fenfluramine repurposing from weight loss to epilepsy: What we do and do not know.
Odi R, Invernizzi RW, Gallily T, Bialer M, Perucca E. Odi R, et al. Pharmacol Ther. 2021 Oct;226:107866. doi: 10.1016/j.pharmthera.2021.107866. Epub 2021 Apr 22. Pharmacol Ther. 2021. PMID: 33895186 Review.
In particular, appetite suppression can be ascribed mainly to the enantiomers d-fenfluramine and d-norfenfluramine, the primary metabolite of d-fenfluramine, whereas cardiac valvulopathy can be ascribed mainly to d-norfenfluramine. ...Despite evidence that stimulati …
In particular, appetite suppression can be ascribed mainly to the enantiomers d-fenfluramine and d-norfenfluramine, the primary metab …
Review of fenfluramine in the treatment of the developmental disabilities.
Aman MG, Kern RA. Aman MG, et al. J Am Acad Child Adolesc Psychiatry. 1989 Jul;28(4):549-65. doi: 10.1097/00004583-198907000-00014. J Am Acad Child Adolesc Psychiatry. 1989. PMID: 2670881 Review.
Fenfluramine, a serotonin reducing agent, has been the subject of intense research effort in recent years. A variety of biochemical studies summarized suggest that some autistic children and many nonautistic severely retarded individuals have elevated blood serotonin conce …
Fenfluramine, a serotonin reducing agent, has been the subject of intense research effort in recent years. A variety of biochemical s …
Fenfluramine acts as a positive modulator of sigma-1 receptors.
Martin P, de Witte PAM, Maurice T, Gammaitoni A, Farfel G, Galer B. Martin P, et al. Epilepsy Behav. 2020 Apr;105:106989. doi: 10.1016/j.yebeh.2020.106989. Epub 2020 Mar 10. Epilepsy Behav. 2020. PMID: 32169824 Free article.
This study investigated a potential role for sigma(1) receptor activity in complementing fenfluramine's serotonergic pharmacology. METHODS: Radioligand binding assays tested the affinity of fenfluramine for 47 receptors associated with seizures in the literat …
This study investigated a potential role for sigma(1) receptor activity in complementing fenfluramine's serotonergic pharmacol …
Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity.
Pinder RM, Brogden RN, Sawyer PR, Speight TM, Avery GS. Pinder RM, et al. Drugs. 1975;10(4):241-323. doi: 10.2165/00003495-197510040-00001. Drugs. 1975. PMID: 765100 Review.
Fenfluramine has been used for a number of years as a short-term adjunct to diet in the management of obesity. ...Unlike other amphetamine-derived anorectics, fenfluramine is not a central stimulant in therapeutic doses, and it probably has little abuse potential... …
Fenfluramine has been used for a number of years as a short-term adjunct to diet in the management of obesity. ...Unlike other amphet …
Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population.
Schoonjans AS, Marchau F, Paelinck BP, Lagae L, Gammaitoni A, Pringsheim M, Keane MG, Ceulemans B. Schoonjans AS, et al. Curr Med Res Opin. 2017 Oct;33(10):1773-1781. doi: 10.1080/03007995.2017.1355781. Epub 2017 Jul 31. Curr Med Res Opin. 2017. PMID: 28704161 Review.
This review was conducted to assess cardiac safety of fenfluramine when used at lower doses for treatment of DS. METHODS: Pubmed was searched for clinical studies of fenfluramine in obese adults who reported incidence of heart valve disease. These data were reviewed …
This review was conducted to assess cardiac safety of fenfluramine when used at lower doses for treatment of DS. METHODS: Pubmed was …
A close look at fenfluramine and dexfenfluramine.
Vivero LE, Anderson PO, Clark RF. Vivero LE, et al. J Emerg Med. 1998 Mar-Apr;16(2):197-205. doi: 10.1016/S0736-4679(97)00289-8. J Emerg Med. 1998. PMID: 9543401 Review.
Concomitant administration of fenfluramine or dexfenfluramine with medications that enhance serotonin levels (e.g., antidepressants, monoamine oxidase inhibitors, and migraine medications) can precipitate serotonin syndrome. Sudden discontinuation of fenfluramine …
Concomitant administration of fenfluramine or dexfenfluramine with medications that enhance serotonin levels (e.g., antidepres …
Fenfluramine studies.
Derôme-Tremblay M, Nathan C. Derôme-Tremblay M, et al. Science. 1989 Feb 24;243(4894 Pt 1):991. doi: 10.1126/science.2922597. Science. 1989. PMID: 2922597 No abstract available.
[Evaluation of the treatment with fenfluramine of autism in children].
de Villard R, Ceillier-Hoppenot B, Flachaire E, Dalery J, Rebaud B, Maillet J, Revol O, Mamelle JC, Quincy C. de Villard R, et al. Pediatrie. 1988;43(8):703-8. Pediatrie. 1988. PMID: 3065724 Review. French.
The effects of fenfluramine were studied in a group of 44 children with the autistic syndrome and in 26 non autistic children with behavior abnormalities, mostly hyperkinetic children, as a control group. ...Platelet serotonin levels were studied in both groups, showing a …
The effects of fenfluramine were studied in a group of 44 children with the autistic syndrome and in 26 non autistic children with be …
Clinical studies with d-fenfluramine.
Guy-Grand B. Guy-Grand B. Am J Clin Nutr. 1992 Jan;55(1 Suppl):173S-176S. doi: 10.1093/ajcn/55.1.173s. Am J Clin Nutr. 1992. PMID: 1728829 Review.
d-Fenfluramine (dF) (15 mg twice daily) has been studied in controlled trials in human obesity and has been shown to increase adherence to diet, to enhance its efficacy, and most importantly, to prevent weight regain when continued over 1 y. ...
d-Fenfluramine (dF) (15 mg twice daily) has been studied in controlled trials in human obesity and has been shown to increase adheren …
Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies.
Sachdev M, Miller WC, Ryan T, Jollis JG. Sachdev M, et al. Am Heart J. 2002 Dec;144(6):1065-73. doi: 10.1067/mhj.2002.126733. Am Heart J. 2002. PMID: 12486432 Review.
BACKGROUND: Fenfluramine-derivative diet pills were withdrawn from the market in 1997 because of an association with valvular regurgitation, but subsequent estimates of the prevalence of this condition have varied widely. We systematically reviewed evidence regarding the p …
BACKGROUND: Fenfluramine-derivative diet pills were withdrawn from the market in 1997 because of an association with valvular regurgi …
4,053 results