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85 results
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Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation.
Hinnerwisch J, Fenton WA, Furtak KJ, Farr GW, Horwich AL. Hinnerwisch J, et al. Among authors: fenton wa. Cell. 2005 Jul 1;121(7):1029-41. doi: 10.1016/j.cell.2005.04.012. Cell. 2005. PMID: 15989953
ATP-triggered ADP release from the asymmetric chaperonin GroEL/GroES/ADP7 is not the rate-limiting step of the GroEL/GroES reaction cycle.
Tyagi NK, Fenton WA, Horwich AL. Tyagi NK, et al. Among authors: fenton wa. FEBS Lett. 2010 Mar 5;584(5):951-3. doi: 10.1016/j.febslet.2010.01.021. Epub 2010 Jan 17. FEBS Lett. 2010. PMID: 20083109 Free PMC article.
GroEL/GroES cycling: ATP binds to an open ring before substrate protein favoring protein binding and production of the native state.
Tyagi NK, Fenton WA, Horwich AL. Tyagi NK, et al. Among authors: fenton wa. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20264-9. doi: 10.1073/pnas.0911556106. Epub 2009 Nov 13. Proc Natl Acad Sci U S A. 2009. PMID: 19915138 Free PMC article.
Chaperonin-mediated protein folding: using a central cavity to kinetically assist polypeptide chain folding.
Horwich AL, Fenton WA. Horwich AL, et al. Among authors: fenton wa. Q Rev Biophys. 2009 May;42(2):83-116. doi: 10.1017/S0033583509004764. Epub 2009 Jul 29. Q Rev Biophys. 2009. PMID: 19638247 Review.
Two families of chaperonin: physiology and mechanism.
Horwich AL, Fenton WA, Chapman E, Farr GW. Horwich AL, et al. Among authors: fenton wa. Annu Rev Cell Dev Biol. 2007;23:115-45. doi: 10.1146/annurev.cellbio.23.090506.123555. Annu Rev Cell Dev Biol. 2007. PMID: 17489689 Review.
Perturbed ATPase activity and not "close confinement" of substrate in the cis cavity affects rates of folding by tail-multiplied GroEL.
Farr GW, Fenton WA, Horwich AL. Farr GW, et al. Among authors: fenton wa. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5342-7. doi: 10.1073/pnas.0700820104. Epub 2007 Mar 19. Proc Natl Acad Sci U S A. 2007. PMID: 17372195 Free PMC article.
GroEL-GroES-mediated protein folding.
Horwich AL, Farr GW, Fenton WA. Horwich AL, et al. Among authors: fenton wa. Chem Rev. 2006 May;106(5):1917-30. doi: 10.1021/cr040435v. Chem Rev. 2006. PMID: 16683761 Review. No abstract available.
Roles of the N-domains of the ClpA unfoldase in binding substrate proteins and in stable complex formation with the ClpP protease.
Hinnerwisch J, Reid BG, Fenton WA, Horwich AL. Hinnerwisch J, et al. Among authors: fenton wa. J Biol Chem. 2005 Dec 9;280(49):40838-44. doi: 10.1074/jbc.M507879200. Epub 2005 Oct 5. J Biol Chem. 2005. PMID: 16207718
No evidence for a forced-unfolding mechanism during ATP/GroES binding to substrate-bound GroEL: no observable protection of metastable Rubisco intermediate or GroEL-bound Rubisco from tritium exchange.
Park ES, Fenton WA, Horwich AL. Park ES, et al. Among authors: fenton wa. FEBS Lett. 2005 Feb 14;579(5):1183-6. doi: 10.1016/j.febslet.2005.01.013. FEBS Lett. 2005. PMID: 15710410
Substrate polypeptide presents a load on the apical domains of the chaperonin GroEL.
Motojima F, Chaudhry C, Fenton WA, Farr GW, Horwich AL. Motojima F, et al. Among authors: fenton wa. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15005-12. doi: 10.1073/pnas.0406132101. Epub 2004 Oct 12. Proc Natl Acad Sci U S A. 2004. PMID: 15479763 Free PMC article.
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