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Creeping baselines and adaptive resistance to antibiotics.
Fernández L, Breidenstein EB, Hancock RE. Fernández L, et al. Drug Resist Updat. 2011 Feb;14(1):1-21. doi: 10.1016/j.drup.2011.01.001. Epub 2011 Feb 1. Drug Resist Updat. 2011. PMID: 21288762 Review.
Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies.
de la Fuente-Núñez C, Reffuveille F, Fernández L, Hancock RE. de la Fuente-Núñez C, et al. Curr Opin Microbiol. 2013 Oct;16(5):580-9. doi: 10.1016/j.mib.2013.06.013. Epub 2013 Jul 20. Curr Opin Microbiol. 2013. PMID: 23880136 Review.
The Lon protease is essential for full virulence in Pseudomonas aeruginosa.
Breidenstein EB, Janot L, Strehmel J, Fernandez L, Taylor PK, Kukavica-Ibrulj I, Gellatly SL, Levesque RC, Overhage J, Hancock RE. Breidenstein EB, et al. PLoS One. 2012;7(11):e49123. doi: 10.1371/journal.pone.0049123. Epub 2012 Nov 7. PLoS One. 2012. PMID: 23145092 Free PMC article.
The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS.
Fernández L, Jenssen H, Bains M, Wiegand I, Gooderham WJ, Hancock RE. Fernández L, et al. Antimicrob Agents Chemother. 2012 Dec;56(12):6212-22. doi: 10.1128/AAC.01530-12. Epub 2012 Sep 24. Antimicrob Agents Chemother. 2012. PMID: 23006746 Free PMC article.
Role of intracellular proteases in the antibiotic resistance, motility, and biofilm formation of Pseudomonas aeruginosa.
Fernández L, Breidenstein EB, Song D, Hancock RE. Fernández L, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):1128-32. doi: 10.1128/AAC.05336-11. Epub 2011 Nov 28. Antimicrob Agents Chemother. 2012. PMID: 22123702 Free PMC article.
The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A.
Arroyo LA, Herrera CM, Fernandez L, Hankins JV, Trent MS, Hancock RE. Arroyo LA, et al. Antimicrob Agents Chemother. 2011 Aug;55(8):3743-51. doi: 10.1128/AAC.00256-11. Epub 2011 Jun 6. Antimicrob Agents Chemother. 2011. PMID: 21646482 Free PMC article.
Involvement of an ATP-dependent protease, PA0779/AsrA, in inducing heat shock in response to tobramycin in Pseudomonas aeruginosa.
Kindrachuk KN, Fernández L, Bains M, Hancock RE. Kindrachuk KN, et al. Antimicrob Agents Chemother. 2011 May;55(5):1874-82. doi: 10.1128/AAC.00935-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357290 Free PMC article.
Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS.
Fernández L, Gooderham WJ, Bains M, McPhee JB, Wiegand I, Hancock RE. Fernández L, et al. Antimicrob Agents Chemother. 2010 Aug;54(8):3372-82. doi: 10.1128/AAC.00242-10. Epub 2010 Jun 14. Antimicrob Agents Chemother. 2010. PMID: 20547815 Free PMC article.
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
Fernández L, Hancock RE. Fernández L, et al. Clin Microbiol Rev. 2012 Oct;25(4):661-81. doi: 10.1128/CMR.00043-12. Clin Microbiol Rev. 2012. PMID: 23034325 Free PMC article. Review.
Characterization of the polymyxin B resistome of Pseudomonas aeruginosa.
Fernández L, Alvarez-Ortega C, Wiegand I, Olivares J, Kocíncová D, Lam JS, Martínez JL, Hancock RE. Fernández L, et al. Antimicrob Agents Chemother. 2013 Jan;57(1):110-9. doi: 10.1128/AAC.01583-12. Epub 2012 Oct 15. Antimicrob Agents Chemother. 2013. PMID: 23070157 Free PMC article.
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