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Kv7 channels can function without constitutive calmodulin tethering.
Gómez-Posada JC, Aivar P, Alberdi A, Alaimo A, Etxeberría A, Fernández-Orth J, Zamalloa T, Roura-Ferrer M, Villace P, Areso P, Casis O, Villarroel A. Gómez-Posada JC, et al. PLoS One. 2011;6(9):e25508. doi: 10.1371/journal.pone.0025508. Epub 2011 Sep 28. PLoS One. 2011. PMID: 21980481 Free PMC article.
Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants.
Alaimo A, Etxeberria A, Gómez-Posada JC, Gomis-Perez C, Fernández-Orth J, Malo C, Villarroel A. Alaimo A, et al. Among authors: Fernandez-Orth J. Channels (Austin). 2018;12(1):299-310. doi: 10.1080/19336950.2018.1511512. Channels (Austin). 2018. PMID: 30126342 Free PMC article.
An unconventional calmodulin-anchoring site within the AB module of Kv7.2 channels.
Gomis-Perez C, Alaimo A, Fernandez-Orth J, Alberdi A, Aivar-Mateo P, Bernardo-Seisdedos G, Malo C, Areso P, Felipe A, Villarroel A. Gomis-Perez C, et al. Among authors: Fernandez-Orth J. J Cell Sci. 2015 Aug 15;128(16):3155-63. doi: 10.1242/jcs.174128. Epub 2015 Jul 6. J Cell Sci. 2015. PMID: 26148514 Free article.
Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex.
Alaimo A, Alberdi A, Gomis-Perez C, Fernández-Orth J, Bernardo-Seisdedos G, Malo C, Millet O, Areso P, Villarroel A. Alaimo A, et al. PLoS One. 2014 Jan 28;9(1):e86711. doi: 10.1371/journal.pone.0086711. eCollection 2014. PLoS One. 2014. PMID: 24489773 Free PMC article.
Cooperativity between calmodulin-binding sites in Kv7.2 channels.
Alaimo A, Alberdi A, Gomis-Perez C, Fernández-Orth J, Gómez-Posada JC, Areso P, Villarroel A. Alaimo A, et al. J Cell Sci. 2013 Jan 1;126(Pt 1):244-53. doi: 10.1242/jcs.114082. Epub 2012 Nov 30. J Cell Sci. 2013. PMID: 23203804
14-3-3 Proteins regulate K2P 5.1 surface expression on T lymphocytes.
Fernández-Orth J, Ehling P, Ruck T, Pankratz S, Hofmann MS, Landgraf P, Dieterich DC, Smalla KH, Kähne T, Seebohm G, Budde T, Wiendl H, Bittner S, Meuth SG. Fernández-Orth J, et al. Traffic. 2017 Jan;18(1):29-43. doi: 10.1111/tra.12455. Epub 2016 Nov 27. Traffic. 2017. PMID: 27743426 Free article.
TREK-king the blood-brain-barrier.
Bittner S, Ruck T, Fernández-Orth J, Meuth SG. Bittner S, et al. Among authors: Fernandez-Orth J. J Neuroimmune Pharmacol. 2014 Jun;9(3):293-301. doi: 10.1007/s11481-014-9530-8. Epub 2014 Feb 21. J Neuroimmune Pharmacol. 2014. PMID: 24557892 Review.
The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis.
Hundehege P, Cerina M, Eichler S, Thomas C, Herrmann AM, Göbel K, Müntefering T, Fernandez-Orth J, Bock S, Narayanan V, Budde T, Speckmann EJ, Wiendl H, Schubart A, Ruck T, Meuth SG. Hundehege P, et al. Among authors: Fernandez-Orth J. Neural Regen Res. 2019 Nov;14(11):1950-1960. doi: 10.4103/1673-5374.259622. Neural Regen Res. 2019. PMID: 31290453 Free PMC article.
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