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Changes in endocannabinoid receptors and enzymes in the spinal cord of SOD1(G93A) transgenic mice and evaluation of a Sativex(®) -like combination of phytocannabinoids: interest for future therapies in amyotrophic lateral sclerosis.
Moreno-Martet M, Espejo-Porras F, Fernández-Ruiz J, de Lago E. Moreno-Martet M, et al. CNS Neurosci Ther. 2014 Sep;20(9):809-15. doi: 10.1111/cns.12262. Epub 2014 Apr 7. CNS Neurosci Ther. 2014. PMID: 24703394 Free PMC article.
Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.
Lastres-Becker I, Hansen HH, Berrendero F, De Miguel R, Pérez-Rosado A, Manzanares J, Ramos JA, Fernández-Ruiz J. Lastres-Becker I, et al. Synapse. 2002 Apr;44(1):23-35. doi: 10.1002/syn.10054. Synapse. 2002. PMID: 11842443
UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide.
de Lago E, Fernández-Ruiz J, Ortega-Gutiérrez S, Viso A, López-Rodríguez ML, Ramos JA. de Lago E, et al. Eur J Pharmacol. 2002 Aug 2;449(1-2):99-103. doi: 10.1016/s0014-2999(02)01996-9. Eur J Pharmacol. 2002. PMID: 12163112
The endogenous cannabinoid system and the basal ganglia. biochemical, pharmacological, and therapeutic aspects.
Romero J, Lastres-Becker I, de Miguel R, Berrendero F, Ramos JA, Fernández-Ruiz J. Romero J, et al. Pharmacol Ther. 2002 Aug;95(2):137-52. doi: 10.1016/s0163-7258(02)00253-x. Pharmacol Ther. 2002. PMID: 12182961 Review.
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.
Lastres-Becker I, de Miguel R, De Petrocellis L, Makriyannis A, Di Marzo V, Fernández-Ruiz J. Lastres-Becker I, et al. J Neurochem. 2003 Mar;84(5):1097-109. doi: 10.1046/j.1471-4159.2003.01595.x. J Neurochem. 2003. PMID: 12603833
Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.
López-Rodríguez ML, Viso A, Ortega-Gutiérrez S, Fowler CJ, Tiger G, de Lago E, Fernández-Ruiz J, Ramos JA. López-Rodríguez ML, et al. J Med Chem. 2003 Apr 10;46(8):1512-22. doi: 10.1021/jm0210818. J Med Chem. 2003. PMID: 12672252
Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors.
López-Rodríguez ML, Viso A, Ortega-Gutiérrez S, Fowler CJ, Tiger G, de Lago E, Fernández-Ruiz J, Ramos JA. López-Rodríguez ML, et al. Eur J Med Chem. 2003 Apr;38(4):403-12. doi: 10.1016/s0223-5234(03)00045-x. Eur J Med Chem. 2003. PMID: 12750028
In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake.
de Lago E, Ligresti A, Ortar G, Morera E, Cabranes A, Pryce G, Bifulco M, Baker D, Fernandez-Ruiz J, Di Marzo V. de Lago E, et al. Eur J Pharmacol. 2004 Jan 26;484(2-3):249-57. doi: 10.1016/j.ejphar.2003.11.027. Eur J Pharmacol. 2004. PMID: 14744610
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