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p70s6k function is essential for G1 progression.
Lane HA, Fernandez A, Lamb NJ, Thomas G. Lane HA, et al. Nature. 1993 May 13;363(6425):170-2. doi: 10.1038/363170a0. Nature. 1993. PMID: 8483501
The main kinase responsible, p70s6k (refs 6-8), is activated through the phosphorylation of four sites clustered in a putative autoinhibitory domain, which is mediated by a signalling pathway distinct from those used by other well characterized mitogen-activated ser …
The main kinase responsible, p70s6k (refs 6-8), is activated through the phosphorylation of four sites clustered in a putative autoin …
Deregulation of translational control of the 65-kDa regulatory subunit (PR65 alpha) of protein phosphatase 2A leads to multinucleated cells.
Wera S, Fernandez A, Lamb NJ, Turowski P, Hemmings-Mieszczak M, Mayer-Jaekel RE, Hemmings BA. Wera S, et al. J Biol Chem. 1995 Sep 8;270(36):21374-81. doi: 10.1074/jbc.270.36.21374. J Biol Chem. 1995. PMID: 7673173
Cells transfected or microinjected with a PR65 alpha expression vector lacking the 5'-UTR, express high levels of PR65 alpha, accumulating in both nucleus and cytoplasm. ...A., and Glover, D. M. (1993) Cell 72, 621-633) suggest that PP2A participates in the regulati …
Cells transfected or microinjected with a PR65 alpha expression vector lacking the 5'-UTR, express high levels of PR65 alpha, accumul …
Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression.
Turowski P, Fernandez A, Favre B, Lamb NJ, Hemmings BA. Turowski P, et al. J Cell Biol. 1995 Apr;129(2):397-410. doi: 10.1083/jcb.129.2.397. J Cell Biol. 1995. PMID: 7721943 Free PMC article.
Specifically a demethylated form of PP2Ac is found in the cytoplasm of G1 cells, and in the nucleus of S and G2 cells. In addition nuclear PP2A holoenzymes appear to undergo conformational changes at the G0/G1 and G1/S boundaries. ...
Specifically a demethylated form of PP2Ac is found in the cytoplasm of G1 cells, and in the nucleus of S and G2 cells. In addition nu …
Nuclear localization of p85s6k: functional requirement for entry into S phase.
Reinhard C, Fernandez A, Lamb NJ, Thomas G. Reinhard C, et al. EMBO J. 1994 Apr 1;13(7):1557-65. EMBO J. 1994. PMID: 8156994 Free PMC article.
Immunolocalization of a newly described isoform of p70s6k, termed p85s6k, demonstrated a predominantly nuclear location in rat embryo fibroblasts (REF-52), a compartment in which growth factor-mediated phosphorylation of S6 has recently been reported. ...The …
Immunolocalization of a newly described isoform of p70s6k, termed p85s6k, demonstrated a predominantly nuclear location in rat …
Role of translocation in the activation and function of protein kinase B.
Andjelković M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA. Andjelković M, et al. J Biol Chem. 1997 Dec 12;272(50):31515-24. doi: 10.1074/jbc.272.50.31515. J Biol Chem. 1997. PMID: 9395488
A dominant negative form of phosphoinositide 3-kinase (PI3-K) did not affect m/p-PKBalpha activity. The pleckstrin homology (PH) domain of m/p-PKBalpha was not required for its activation or phosphorylation on Thr308 and Ser473, suggesting that this domain may serve as
A dominant negative form of phosphoinositide 3-kinase (PI3-K) did not affect m/p-PKBalpha activity. The pleckstrin homology (PH) doma
PAF-induced airway responses in sheep: effects of a PAF antagonist and nedocromil sodium.
Soler M, Mansour E, Fernandez A, D'Brot J, Ahmed T, Abraham WM. Soler M, et al. J Allergy Clin Immunol. 1990 Mar;85(3):661-8. doi: 10.1016/0091-6749(90)90108-g. J Allergy Clin Immunol. 1990. PMID: 2155959
Platelet-activating factor (PAF) is a potent inflammatory mediator that can cause bronchoconstriction and airway hyperresponsiveness in selected human subjects and animals. ...Two to 4 hours after PAF instillation, PD4 decreased by 55 +/- 9% from a baseline of 39 +/ …
Platelet-activating factor (PAF) is a potent inflammatory mediator that can cause bronchoconstriction and airway hyperresponsiveness …
Detection of CSF1 rearrangements deleting the 3' UTR in tenosynovial giant cell tumors.
Ho J, Peters T, Dickson BC, Swanson D, Fernandez A, Frova-Seguin A, Valentin MA, Schramm U, Sultan M, Nielsen TO, Demicco EG. Ho J, et al. Genes Chromosomes Cancer. 2020 Feb;59(2):96-105. doi: 10.1002/gcc.22807. Epub 2019 Sep 12. Genes Chromosomes Cancer. 2020. PMID: 31469468
While fusions to collagen promoters have been described, the mechanism of CSF1 overexpression has been unclear in a majority of cases. ...The diversity of fusion partners but consistent integrity of CSF1 functional domains encoded by exons 1-5 support a hypothesis t …
While fusions to collagen promoters have been described, the mechanism of CSF1 overexpression has been unclear in a majority of cases …
MAKO CT-based robotic arm-assisted system is a reliable procedure for total knee arthroplasty: a systematic review.
Batailler C, Fernandez A, Swan J, Servien E, Haddad FS, Catani F, Lustig S. Batailler C, et al. Among authors: fernandez a. Knee Surg Sports Traumatol Arthrosc. 2020 Sep 25. doi: 10.1007/s00167-020-06283-z. Online ahead of print. Knee Surg Sports Traumatol Arthrosc. 2020. PMID: 32975626 Review.
HPS11 and OCA8: two new types of albinism associated with mutations in BLOC1S5 and DCT genes.
Garrido G, Fernández A, Montoliu L. Garrido G, et al. Among authors: fernandez a. Pigment Cell Melanoma Res. 2020 Sep 24. doi: 10.1111/pcmr.12929. Online ahead of print. Pigment Cell Melanoma Res. 2020. PMID: 32969584
Boundary sequences flanking the mouse tyrosinase locus ensure faithful pattern of gene expression.
Seruggia D, Fernández A, Cantero M, Fernández-Miñán A, Gomez-Skarmeta JL, Pelczar P, Montoliu L. Seruggia D, et al. Among authors: fernandez a. Sci Rep. 2020 Sep 23;10(1):15494. doi: 10.1038/s41598-020-72543-0. Sci Rep. 2020. PMID: 32968154
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