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Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.
Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. Zhong Z, et al. Among authors: fernandez ja. J Clin Invest. 2009 Nov;119(11):3437-49. doi: 10.1172/JCI38476. Epub 2009 Oct 19. J Clin Invest. 2009. PMID: 19841542 Free PMC article.
Protein C inhibitor is expressed in tubular cells of human kidney.
Radtke KP, Fernández JA, Greengard JS, Tang WW, Wilson CB, Loskutoff DJ, Scharrer I, Griffin JH. Radtke KP, et al. Among authors: fernandez ja. J Clin Invest. 1994 Nov;94(5):2117-24. doi: 10.1172/JCI117566. J Clin Invest. 1994. PMID: 7525654 Free PMC article.
Activated protein C resistance: molecular mechanisms.
Griffin JH, Heeb MJ, Kojima Y, Fernández JA, Kojima K, Hackeng TM, Greengard JS. Griffin JH, et al. Among authors: fernandez ja. Thromb Haemost. 1995 Jul;74(1):444-8. Thromb Haemost. 1995. PMID: 8578503 Review.
Upregulation of the antithrombotic protein C pathway at birth.
Petäjä J, Fernández JA, Fellman V, Griffin JH. Petäjä J, et al. Among authors: fernandez ja. Pediatr Hematol Oncol. 1998 Nov-Dec;15(6):489-99. doi: 10.3109/08880019809018310. Pediatr Hematol Oncol. 1998. PMID: 9842642
746 results