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Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?
Le Hellard S, Theisen FM, Haberhausen M, Raeder MB, Fernø J, Gebhardt S, Hinney A, Remschmidt H, Krieg JC, Mehler-Wex C, Nöthen MM, Hebebrand J, Steen VM. Le Hellard S, et al. Among authors: ferno j. Mol Psychiatry. 2009 Mar;14(3):308-17. doi: 10.1038/sj.mp.4002133. Epub 2008 Jan 15. Mol Psychiatry. 2009. PMID: 18195716
Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.
Le Hellard S, Mühleisen TW, Djurovic S, Fernø J, Ouriaghi Z, Mattheisen M, Vasilescu C, Raeder MB, Hansen T, Strohmaier J, Georgi A, Brockschmidt FF, Melle I, Nenadic I, Sauer H, Rietschel M, Nöthen MM, Werge T, Andreassen OA, Cichon S, Steen VM. Le Hellard S, et al. Among authors: ferno j. Mol Psychiatry. 2010 May;15(5):463-72. doi: 10.1038/mp.2008.110. Epub 2008 Oct 21. Mol Psychiatry. 2010. PMID: 18936756
Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver.
Fernø J, Vik-Mo AO, Jassim G, Håvik B, Berge K, Skrede S, Gudbrandsen OA, Waage J, Lunder N, Mørk S, Berge RK, Jørgensen HA, Steen VM. Fernø J, et al. Psychopharmacology (Berl). 2009 Mar;203(1):73-84. doi: 10.1007/s00213-008-1370-x. Epub 2008 Oct 30. Psychopharmacology (Berl). 2009. PMID: 18989661
86 results