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Genetic analysis of muscle development in Drosophila melanogaster.
de la Pompa JL, Garcia JR, Ferrús A. de la Pompa JL, et al. Dev Biol. 1989 Feb;131(2):439-54. doi: 10.1016/s0012-1606(89)80016-8. Dev Biol. 1989. PMID: 2492244
A quantitative, rather than a qualitative, specificity is found in the mutant phenotypes. All muscles are altered by mutations in any given gene, but the severity of these alterations is muscle specific. The locus stripe seems to have a polar organization whe
A quantitative, rather than a qualitative, specificity is found in the mutant phenotypes. All muscles are altered by mutations
Parameters of mitotic recombination in minute mutants of Drosophila melanogaster.
Ferrus A. Ferrus A. Genetics. 1975 Apr;79(4):589-99. Genetics. 1975. PMID: 805750 Free PMC article.
A sample of 16 Minutes, representing 12 loci distributed over all the chromosome arms and including 3 pairs of alleles and 4 deficiencies, has been studied with respect to several developmental and recombinational parameters. ...
A sample of 16 Minutes, representing 12 loci distributed over all the chromosome arms and including 3 pairs of alleles and 4 deficien
Two frequenins in Drosophila: unveiling the evolutionary history of an unusual neuronal calcium sensor (NCS) duplication.
Sánchez-Gracia A, Romero-Pozuelo J, Ferrús A. Sánchez-Gracia A, et al. BMC Evol Biol. 2010 Feb 19;10:54. doi: 10.1186/1471-2148-10-54. BMC Evol Biol. 2010. PMID: 20170488 Free PMC article.
BACKGROUND: Drosophila frequenin (Frq), the homolog of the mammalian neuronal calcium sensor-1 (NCS-1), is a high affinity calcium-binding protein with ubiquitous expression in the nervous system. ...In D. melanogaster, frequenin is encoded by two genes (frq1 and frq2), …
BACKGROUND: Drosophila frequenin (Frq), the homolog of the mammalian neuronal calcium sensor-1 (NCS-1), is a high affinity calcium-bi …
Frq2 from Drosophila melanogaster: cloning, expression, purification, crystallization and preliminary X-ray analysis.
Baños-Mateos S, Chaves-Sanjuán A, Mansilla A, Ferrús A, Sánchez-Barrena MJ. Baños-Mateos S, et al. Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):530-4. doi: 10.1107/S2053230X14005408. Epub 2014 Mar 25. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24699756 Free PMC article.
The full-length protein was purified using a two-step chromatographic procedure. Two different diffracting crystal forms were obtained using a progressive streak-seeding method and detergents....
The full-length protein was purified using a two-step chromatographic procedure. Two different diffracting crystal forms were obtaine …
Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster.
Gradilla AC, Mansilla A, Ferrús A. Gradilla AC, et al. Genetics. 2011 Nov;189(3):871-83. doi: 10.1534/genetics.111.132191. Epub 2011 Sep 6. Genetics. 2011. PMID: 21900267 Free PMC article.
The EcR gene encodes three protein isoforms--A, B1, and B2--with variant N-terminal domains that mediate tissue and developmental stage-specific responses to 20E. Ariadne-1a is a conserved member of the RING finger family of ubiquitin ligases first identified in Dro …
The EcR gene encodes three protein isoforms--A, B1, and B2--with variant N-terminal domains that mediate tissue and developmental sta …
Troponin I and Tropomyosin regulate chromosomal stability and cell polarity.
Sahota VK, Grau BF, Mansilla A, Ferrús A. Sahota VK, et al. J Cell Sci. 2009 Aug 1;122(Pt 15):2623-31. doi: 10.1242/jcs.050880. Epub 2009 Jun 30. J Cell Sci. 2009. PMID: 19567471
The Troponin-Tropomyosin (Tn-Tm) complex regulates muscle contraction through a series of Ca(2+)-dependent conformational changes that control actin-myosin interactions. ...These data illustrate, for the first time, a role for TnI in the nucleus and/or the cytoskele …
The Troponin-Tropomyosin (Tn-Tm) complex regulates muscle contraction through a series of Ca(2+)-dependent conformational changes tha …
Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology.
Romero-Pozuelo J, Dason JS, Atwood HL, Ferrús A. Romero-Pozuelo J, et al. Eur J Neurosci. 2007 Nov;26(9):2428-43. doi: 10.1111/j.1460-9568.2007.05877.x. Epub 2007 Oct 26. Eur J Neurosci. 2007. PMID: 17970740
In both cases, a 70% reduction in quantal content per bouton occurred, demonstrating that this trait does not result from homeostatic adaptations of the synapse during development. ...By contrast, excess-of-function conditions yielded a 1.4- to 2-fold increase in qu …
In both cases, a 70% reduction in quantal content per bouton occurred, demonstrating that this trait does not result from homeostatic …
Transcriptional adaptor ADA3 of Drosophila melanogaster is required for histone modification, position effect variegation, and transcription.
Grau B, Popescu C, Torroja L, Ortuño-Sahagún D, Boros I, Ferrús A. Grau B, et al. Mol Cell Biol. 2008 Jan;28(1):376-85. doi: 10.1128/MCB.01307-07. Epub 2007 Oct 29. Mol Cell Biol. 2008. PMID: 17967867 Free PMC article.
The Drosophila melanogaster gene diskette (also known as dik or dAda3) encodes a protein 29% identical to human ADA3, a subunit of GCN5-containing histone acetyltransferase (HAT) complexes. ...Variegation for white (w(m4)) and scute (Hw(v)) genes, caused by rearrang …
The Drosophila melanogaster gene diskette (also known as dik or dAda3) encodes a protein 29% identical to human ADA3, a subuni …
Transcription of Drosophila troponin I gene is regulated by two conserved, functionally identical, synergistic elements.
Marín MC, Rodríguez JR, Ferrús A. Marín MC, et al. Mol Biol Cell. 2004 Mar;15(3):1185-96. doi: 10.1091/mbc.e03-09-0663. Epub 2004 Jan 12. Mol Biol Cell. 2004. PMID: 14718563 Free PMC article.
Using exon specific probes, we show that transvection is based on transcriptional changes in the homologous chromosome and that Zeste and Suppressor of Zeste 3 gene products act as repressors for wings-up A. ...Troponin I (TnI) is expressed before muscle progenitors begin …
Using exon specific probes, we show that transvection is based on transcriptional changes in the homologous chromosome and that Zeste and Su …
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