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The molecular basis of T cell acute lymphoblastic leukemia.
Van Vlierberghe P, Ferrando A. Van Vlierberghe P, et al. Among authors: ferrando a. J Clin Invest. 2012 Oct;122(10):3398-406. doi: 10.1172/JCI61269. Epub 2012 Oct 1. J Clin Invest. 2012. PMID: 23023710 Free PMC article. Review.
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in t …
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell deve …
Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia.
Ferrando AA, Look AT. Ferrando AA, et al. Semin Hematol. 2000 Oct;37(4):381-95. doi: 10.1016/s0037-1963(00)90018-0. Semin Hematol. 2000. PMID: 11071360 Review.
By contrast, the t(1;19)/E2A-PBX1 identifies a subtype of ALL that responds much better to more intensive regimens that rely on genotoxic drugs. At the extreme end of the risk spectrum, the t(4;11)/MLL-AF4 and t(9;22)/BCR-ABL almost always confer a dire prognosis in …
By contrast, the t(1;19)/E2A-PBX1 identifies a subtype of ALL that responds much better to more intensive regimens that rely on genot …
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT. Ferrando AA, et al. Cancer Cell. 2002 Feb;1(1):75-87. doi: 10.1016/s1535-6108(02)00018-1. Cancer Cell. 2002. PMID: 12086890
Hierarchical clustering analysis of gene expression signatures grouped samples according to their shared oncogenic pathways and identified HOX11L2 activation as a novel event in T cell leukemogenesis. These findings have clinical importance, since HOX11 activation is signi …
Hierarchical clustering analysis of gene expression signatures grouped samples according to their shared oncogenic pathways and identified H …
Myc-induced T cell leukemia in transgenic zebrafish.
Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT. Langenau DM, et al. Among authors: ferrando aa. Science. 2003 Feb 7;299(5608):887-90. doi: 10.1126/science.1080280. Science. 2003. PMID: 12574629
Visualization of leukemic cells expressing a chimeric transgene encoding Myc fused to green fluorescent protein (GFP) revealed that leukemias arose in the thymus, spread locally into gill arches and retro-orbital soft tissue, and then disseminated into skeletal muscle and …
Visualization of leukemic cells expressing a chimeric transgene encoding Myc fused to green fluorescent protein (GFP) revealed that l …
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.
Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ, Look AT. Ferrando AA, et al. Blood. 2003 Jul 1;102(1):262-8. doi: 10.1182/blood-2002-10-3221. Epub 2003 Mar 13. Blood. 2003. PMID: 12637319
Overall, MLL T-ALL cases consistently demonstrated increased levels of expression of a subset of major HOX genes--HOXA9, HOXA10, and HOXC6--and the MEIS1 HOX coregulator (P<.008, one-sided Wilcoxon test), a pattern of gene expression that was reiterated in MLL B- …
Overall, MLL T-ALL cases consistently demonstrated increased levels of expression of a subset of major HOX genes--HOXA9, HOXA10, and …
Gene expression profiling in T-cell acute lymphoblastic leukemia.
Ferrando AA, Look AT. Ferrando AA, et al. Semin Hematol. 2003 Oct;40(4):274-80. doi: 10.1016/s0037-1963(03)00195-1. Semin Hematol. 2003. PMID: 14582078 Review.
Gene expression studies indicate activation of a subset of these genes-HOX11, TAL1, LYL1, LMO1, and LMO2-in a much larger fraction of T-ALL cases than those harboring activating chromosomal translocations. ...Supervised learning approaches applied to microarray data …
Gene expression studies indicate activation of a subset of these genes-HOX11, TAL1, LYL1, LMO1, and LMO2-in a much larger frac …
Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia.
Ferrando AA, Herblot S, Palomero T, Hansen M, Hoang T, Fox EA, Look AT. Ferrando AA, et al. Blood. 2004 Mar 1;103(5):1909-11. doi: 10.1182/blood-2003-07-2577. Epub 2003 Nov 6. Blood. 2004. PMID: 14604958
We propose that aberrant expression of oncogenic transcription factors in a significant fraction of T-ALLs may result from loss of the upstream transcriptional mechanisms that normally down-regulate the expression of these oncogenes during T-cell development....
We propose that aberrant expression of oncogenic transcription factors in a significant fraction of T-ALLs may result from loss of th …
IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.
Barata JT, Boussiotis VA, Yunes JA, Ferrando AA, Moreau LA, Veiga JP, Sallan SE, Look AT, Nadler LM, Cardoso AA. Barata JT, et al. Among authors: ferrando aa. Blood. 2004 Mar 1;103(5):1891-900. doi: 10.1182/blood-2002-12-3861. Epub 2003 Nov 13. Blood. 2004. PMID: 14615384
We established a human interleukin-7 (IL-7)-dependent T-ALL cell line, TAIL7, that maintains several biologic and signaling properties of its parental leukemia cells. ...Because TAIL7 cells seem to be a biologic surrogate for primary leukemia T cells, this cell line …
We established a human interleukin-7 (IL-7)-dependent T-ALL cell line, TAIL7, that maintains several biologic and signaling propertie …
Requirement for cyclin D3 in lymphocyte development and T cell leukemias.
Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, Sicinski P. Sicinska E, et al. Among authors: ferrando aa. Cancer Cell. 2003 Dec;4(6):451-61. doi: 10.1016/s1535-6108(03)00301-5. Cancer Cell. 2003. PMID: 14706337
These studies point to cyclin D3 as a potential target for therapeutic intervention in specific human malignancies....
These studies point to cyclin D3 as a potential target for therapeutic intervention in specific human malignancies....
Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia.
Ferrando AA, Neuberg DS, Dodge RK, Paietta E, Larson RA, Wiernik PH, Rowe JM, Caligiuri MA, Bloomfield CD, Look AT. Ferrando AA, et al. Lancet. 2004 Feb 14;363(9408):535-6. doi: 10.1016/S0140-6736(04)15542-6. Lancet. 2004. PMID: 14975618
Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. ...
Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. ...
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