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Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors.
Di Pucchio T, Pilla L, Capone I, Ferrantini M, Montefiore E, Urbani F, Patuzzo R, Pennacchioli E, Santinami M, Cova A, Sovena G, Arienti F, Lombardo C, Lombardi A, Caporaso P, D'Atri S, Marchetti P, Bonmassar E, Parmiani G, Belardelli F, Rivoltini L. Di Pucchio T, et al. Among authors: ferrantini m. Cancer Res. 2006 May 1;66(9):4943-51. doi: 10.1158/0008-5472.CAN-05-3396. Cancer Res. 2006. PMID: 16651452 Clinical Trial.
Monocyte-derived dendritic cells generated after a short-term culture with IFN-alpha and granulocyte-macrophage colony-stimulating factor stimulate a potent Epstein-Barr virus-specific CD8+ T cell response.
Santodonato L, D'Agostino G, Nisini R, Mariotti S, Monque DM, Spada M, Lattanzi L, Perrone MP, Andreotti M, Belardelli F, Ferrantini M. Santodonato L, et al. Among authors: ferrantini m. J Immunol. 2003 May 15;170(10):5195-202. doi: 10.4049/jimmunol.170.10.5195. J Immunol. 2003. PMID: 12734367
Dendritic cells and cytokines in immune rejection of cancer.
Ferrantini M, Capone I, Belardelli F. Ferrantini M, et al. Cytokine Growth Factor Rev. 2008 Feb;19(1):93-107. doi: 10.1016/j.cytogfr.2007.10.003. Epub 2007 Dec 3. Cytokine Growth Factor Rev. 2008. PMID: 18054517 Review.
IFN-alpha in the generation of dendritic cells for cancer immunotherapy.
Santini SM, Lapenta C, Santodonato L, D'Agostino G, Belardelli F, Ferrantini M. Santini SM, et al. Among authors: ferrantini m. Handb Exp Pharmacol. 2009;(188):295-317. doi: 10.1007/978-3-540-71029-5_14. Handb Exp Pharmacol. 2009. PMID: 19031032 Review.
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