Ferrer J - Search Results

1

Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.

Maestro MA, Cardalda C, Boj SF, Luco RF, Servitja JM, Ferrer J. Maestro MA, et al. Among authors: ferrer j. Endocr Dev. 2007;12:33-45. doi: 10.1159/000109603. Endocr Dev. 2007. PMID: 17923767 Review.

2

A genetic switch in pancreatic beta-cells: implications for differentiation and haploinsufficiency.

Ferrer J. Ferrer J. Diabetes. 2002 Aug;51(8):2355-62. doi: 10.2337/diabetes.51.8.2355. Diabetes. 2002. PMID: 12145145 Review.

3

A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious.

Luco RF, Maestro MA, del Pozo N, Philbrick WM, de la Ossa PP, Ferrer J. Luco RF, et al. Among authors: ferrer j. Diabetes. 2006 Aug;55(8):2202-11. doi: 10.2337/db05-1534. Diabetes. 2006. PMID: 16873682

4

Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets.

Luco RF, Maestro MA, Sadoni N, Zink D, Ferrer J. Luco RF, et al. Among authors: ferrer j. PLoS Genet. 2008 May 23;4(5):e1000079. doi: 10.1371/journal.pgen.1000079. PLoS Genet. 2008. PMID: 18497863 Free PMC article.

5

Functional targets of the monogenic diabetes transcription factors HNF-1alpha and HNF-4alpha are highly conserved between mice and humans.

Boj SF, Servitja JM, Martin D, Rios M, Talianidis I, Guigo R, Ferrer J. Boj SF, et al. Among authors: ferrer j. Diabetes. 2009 May;58(5):1245-53. doi: 10.2337/db08-0812. Epub 2009 Feb 2. Diabetes. 2009. PMID: 19188435 Free PMC article.

6

Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.

Servitja JM, Pignatelli M, Maestro MA, Cardalda C, Boj SF, Lozano J, Blanco E, Lafuente A, McCarthy MI, Sumoy L, Guigó R, Ferrer J. Servitja JM, et al. Among authors: ferrer j. Mol Cell Biol. 2009 Jun;29(11):2945-59. doi: 10.1128/MCB.01389-08. Epub 2009 Mar 16. Mol Cell Biol. 2009. PMID: 19289501 Free PMC article.

7

Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.

Solar M, Cardalda C, Houbracken I, Martín M, Maestro MA, De Medts N, Xu X, Grau V, Heimberg H, Bouwens L, Ferrer J. Solar M, et al. Among authors: ferrer j. Dev Cell. 2009 Dec;17(6):849-60. doi: 10.1016/j.devcel.2009.11.003. Dev Cell. 2009. PMID: 20059954 Free article.

8

Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.

Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM, Maestro MA, Alshaikh A, Bundak R, del Castillo G, Deeb A, Deiss D, Fernandez JM, Godbole K, Hussain K, O'Connell M, Klupa T, Kolouskova S, Mohsin F, Perlman K, Sumnik Z, Rial JM, Ugarte E, Vasanthi T; Neonatal Diabetes International Group; Johnstone K, Flanagan SE, Martínez R, Castaño C, Patch AM, Fernández-Rebollo E, Raile K, Morgan N, Harries LW, Castaño L, Ellard S, Ferrer J, Perez de Nanclares G, Hattersley AT. Garin I, et al. Among authors: ferrer j. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3105-10. doi: 10.1073/pnas.0910533107. Epub 2010 Jan 28. Proc Natl Acad Sci U S A. 2010. PMID: 20133622 Free PMC article.

9

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program.

van Arensbergen J, García-Hurtado J, Moran I, Maestro MA, Xu X, Van de Casteele M, Skoudy AL, Palassini M, Heimberg H, Ferrer J. van Arensbergen J, et al. Among authors: ferrer j. Genome Res. 2010 Jun;20(6):722-32. doi: 10.1101/gr.101709.109. Epub 2010 Apr 15. Genome Res. 2010. PMID: 20395405 Free PMC article.

10

Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha.

Boj SF, Petrov D, Ferrer J. Boj SF, et al. Among authors: ferrer j. PLoS Genet. 2010 May 27;6(5):e1000970. doi: 10.1371/journal.pgen.1000970. PLoS Genet. 2010. PMID: 20523905 Free PMC article.

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