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533 results
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Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.
Joerger AC, Ang HC, Fersht AR. Joerger AC, et al. Among authors: fersht ar. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. doi: 10.1073/pnas.0607286103. Epub 2006 Oct 2. Proc Natl Acad Sci U S A. 2006. PMID: 17015838 Free PMC article.
Solution structure of a protein denatured state and folding intermediate.
Religa TL, Markson JS, Mayor U, Freund SM, Fersht AR. Religa TL, et al. Among authors: fersht ar. Nature. 2005 Oct 13;437(7061):1053-6. doi: 10.1038/nature04054. Nature. 2005. PMID: 16222301
Use of binding energy in catalysis: optimization of rate in a multistep reaction.
Avis JM, Fersht AR. Avis JM, et al. Among authors: fersht ar. Biochemistry. 1993 May 25;32(20):5321-6. doi: 10.1021/bi00071a006. Biochemistry. 1993. PMID: 8499436
Mutational and kinetic analysis of a mobile loop in tyrosyl-tRNA synthetase.
First EA, Fersht AR. First EA, et al. Among authors: fersht ar. Biochemistry. 1993 Dec 14;32(49):13658-63. doi: 10.1021/bi00212a034. Biochemistry. 1993. PMID: 8257699
Using flexible loop mimetics to extend phi-value analysis to secondary structure interactions.
Ferguson N, Pires JR, Toepert F, Johnson CM, Pan YP, Volkmer-Engert R, Schneider-Mergener J, Daggett V, Oschkinat H, Fersht A. Ferguson N, et al. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13008-13. doi: 10.1073/pnas.221467398. Epub 2001 Oct 30. Proc Natl Acad Sci U S A. 2001. PMID: 11687614 Free PMC article.
Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography.
Karadimitris A, Gadola S, Altamirano M, Brown D, Woolfson A, Klenerman P, Chen JL, Koezuka Y, Roberts IA, Price DA, Dusheiko G, Milstein C, Fersht A, Luzzatto L, Cerundolo V. Karadimitris A, et al. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3294-8. doi: 10.1073/pnas.051604498. Proc Natl Acad Sci U S A. 2001. PMID: 11248072 Free PMC article.
Ultrafast folding of WW domains without structured aromatic clusters in the denatured state.
Ferguson N, Johnson CM, Macias M, Oschkinat H, Fersht A. Ferguson N, et al. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13002-7. doi: 10.1073/pnas.221467198. Epub 2001 Oct 30. Proc Natl Acad Sci U S A. 2001. PMID: 11687613 Free PMC article.
Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007.
Synnott NC, Bauer MR, Madden S, Murray A, Klinger R, O'Donovan N, O'Connor D, Gallagher WM, Crown J, Fersht AR, Duffy MJ. Synnott NC, et al. Among authors: fersht ar. Cancer Lett. 2018 Feb 1;414:99-106. doi: 10.1016/j.canlet.2017.09.053. Epub 2017 Oct 22. Cancer Lett. 2018. PMID: 29069577
Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.
Joerger AC, Bauer MR, Wilcken R, Baud MGJ, Harbrecht H, Exner TE, Boeckler FM, Spencer J, Fersht AR. Joerger AC, et al. Among authors: fersht ar. Structure. 2015 Dec 1;23(12):2246-2255. doi: 10.1016/j.str.2015.10.016. Structure. 2015. PMID: 26636255 Free PMC article.
Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere.
Wilcken R, Zimmermann MO, Bauer MR, Rutherford TJ, Fersht AR, Joerger AC, Boeckler FM. Wilcken R, et al. Among authors: fersht ar. ACS Chem Biol. 2015 Dec 18;10(12):2725-32. doi: 10.1021/acschembio.5b00515. Epub 2015 Oct 1. ACS Chem Biol. 2015. PMID: 26378745 Free PMC article.
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