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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 2
1982 1
1983 3
1984 3
1985 4
1987 4
1988 5
1989 3
1990 5
1991 4
1992 8
1993 8
1994 14
1995 6
1996 9
1997 11
1998 3
1999 10
2000 12
2001 8
2002 4
2003 7
2004 7
2005 7
2006 6
2007 8
2008 5
2010 3
2011 3
2012 4
2013 6
2014 7
2015 5
2016 5
2017 4
2018 9
2019 7
2020 7
2021 2
2022 4
2023 2
2024 5
2025 10
2026 4

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244 results

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Page 1
Drugging the undruggable RAS: Mission possible?
Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Cox AD, et al. Among authors: fesik sw. Nat Rev Drug Discov. 2014 Nov;13(11):828-51. doi: 10.1038/nrd4389. Epub 2014 Oct 17. Nat Rev Drug Discov. 2014. PMID: 25323927 Free PMC article. Review.
The BCL-2 protein family: from discovery to drug development.
Croce CM, Vaux D, Strasser A, Opferman JT, Czabotar PE, Fesik SW. Croce CM, et al. Among authors: fesik sw. Cell Death Differ. 2025 Aug;32(8):1369-1381. doi: 10.1038/s41418-025-01481-z. Epub 2025 Apr 9. Cell Death Differ. 2025. PMID: 40204952 Free PMC article. Review.
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.
Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL. Lee KM, et al. Among authors: fesik sw. Cell Metab. 2017 Oct 3;26(4):633-647.e7. doi: 10.1016/j.cmet.2017.09.009. Cell Metab. 2017. PMID: 28978427 Free PMC article.
Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies.
Meyer CT, Smith BN, Wang J, Teuscher KB, Grieb BC, Howard GC, Silver AJ, Lorey SL, Stott GM, Moore WJ, Lee T, Savona MR, Weissmiller AM, Liu Q, Quaranta V, Fesik SW, Tansey WP. Meyer CT, et al. Among authors: fesik sw. Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2408889121. doi: 10.1073/pnas.2408889121. Epub 2024 Aug 21. Proc Natl Acad Sci U S A. 2024. PMID: 39167600 Free PMC article.
Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy.
Bröker J, Waterson AG, Hodges TR, Abbott JR, Arnold A, Böttcher J, Braun N, Cui J, Fuchs JE, Gerstberger T, Gogg S, Hanner S, Herdeis L, Howell LW, Mantoulidis A, Mayer M, Phan J, Rocchetti F, Sankar K, Sarkar D, Schaaf O, Sensintaffar JL, Sun Q, Wunberg T, Fesik SW. Bröker J, et al. Among authors: fesik sw. J Med Chem. 2025 Aug 14;68(15):15649-15668. doi: 10.1021/acs.jmedchem.5c00576. Epub 2025 Jul 25. J Med Chem. 2025. PMID: 40709733 Free PMC article.
Targeting MYC through WDR5.
Thomas LR, Adams CM, Fesik SW, Eischen CM, Tansey WP. Thomas LR, et al. Among authors: fesik sw. Mol Cell Oncol. 2020 Jan 10;7(2):1709388. doi: 10.1080/23723556.2019.1709388. eCollection 2020. Mol Cell Oncol. 2020. PMID: 32158922 Free PMC article.
Fragment-based drug discovery using NMR spectroscopy.
Harner MJ, Frank AO, Fesik SW. Harner MJ, et al. Among authors: fesik sw. J Biomol NMR. 2013 Jun;56(2):65-75. doi: 10.1007/s10858-013-9740-z. Epub 2013 May 18. J Biomol NMR. 2013. PMID: 23686385 Free PMC article. Review.
Drugging an undruggable pocket on KRAS.
Kessler D, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, Mayer M, Gollner A, Covini D, Fischer S, Gerstberger T, Gmaschitz T, Goodwin C, Greb P, Häring D, Hela W, Hoffmann J, Karolyi-Oezguer J, Knesl P, Kornigg S, Koegl M, Kousek R, Lamarre L, Moser F, Munico-Martinez S, Peinsipp C, Phan J, Rinnenthal J, Sai J, Salamon C, Scherbantin Y, Schipany K, Schnitzer R, Schrenk A, Sharps B, Siszler G, Sun Q, Waterson A, Wolkerstorfer B, Zeeb M, Pearson M, Fesik SW, McConnell DB. Kessler D, et al. Among authors: fesik sw. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15823-15829. doi: 10.1073/pnas.1904529116. Epub 2019 Jul 22. Proc Natl Acad Sci U S A. 2019. PMID: 31332011 Free PMC article.
244 results