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Teratogen update: methotrexate.
Hyoun SC, Običan SG, Scialli AR. Hyoun SC, et al. Birth Defects Res A Clin Mol Teratol. 2012 Apr;94(4):187-207. doi: 10.1002/bdra.23003. Epub 2012 Mar 20. Birth Defects Res A Clin Mol Teratol. 2012. PMID: 22434686 Review.
Methotrexate and aminopterin are folic acid antagonists that inhibit dihydrofolate reductase, resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis. ...More recent case reports of methotrexate exposure for the misdiagnosis of ectopic pregnancy …
Methotrexate and aminopterin are folic acid antagonists that inhibit dihydrofolate reductase, resulting in a block in the synthesis o …
[Fetal aminopterin syndrome].
Muto R, Ohashi H. Muto R, et al. Ryoikibetsu Shokogun Shirizu. 2001;(33):676-7. Ryoikibetsu Shokogun Shirizu. 2001. PMID: 11462628 Review. Japanese. No abstract available.
Developmental delay in fetal aminopterin/methotrexate syndrome.
Del Campo M, Kosaki K, Bennett FC, Jones KL. Del Campo M, et al. Teratology. 1999 Jul;60(1):10-2. doi: 10.1002/(SICI)1096-9926(199907)60:1<10::AID-TERA5>3.0.CO;2-H. Teratology. 1999. PMID: 10413333 Review.
Maternal exposures to aminopterin and methotrexate have been associated with a pattern of malformation which includes prenatal-onset growth deficiency, severe lack of ossification of the calvarium, hypoplastic supraorbital ridges, small, low-set ears, micrognathia, and lim …
Maternal exposures to aminopterin and methotrexate have been associated with a pattern of malformation which includes prenatal-onset …
[Fetal aminopterin syndrome].
Harada M. Harada M. Ryoikibetsu Shokogun Shirizu. 2000;(30 Pt 5):88-9. Ryoikibetsu Shokogun Shirizu. 2000. PMID: 11057154 Review. Japanese. No abstract available.