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Year Number of Results
1915 1
1946 7
1947 16
1948 10
1949 15
1950 7
1951 8
1952 9
1953 17
1954 10
1955 21
1956 16
1957 26
1958 16
1959 14
1960 10
1961 10
1962 18
1963 41
1964 47
1965 30
1966 52
1967 45
1968 71
1969 65
1970 75
1971 97
1972 125
1973 95
1974 109
1975 94
1976 74
1977 95
1978 98
1979 110
1980 89
1981 100
1982 91
1983 93
1984 103
1985 108
1986 110
1987 101
1988 139
1989 136
1990 156
1991 183
1992 186
1993 279
1994 261
1995 325
1996 334
1997 380
1998 379
1999 373
2000 513
2001 489
2002 543
2003 591
2004 581
2005 682
2006 729
2007 795
2008 944
2009 1074
2010 1182
2011 1362
2012 1450
2013 1695
2014 1929
2015 2034
2016 2149
2017 2204
2018 2269
2019 2550
2020 3072
2021 3468
2022 3457
2023 3421
2024 3504
2025 3800
2026 1456

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Page 1
Prenatal Delivery of HIF-1α siRNA Using Transferrin-Modified Lipid Nanoparticles Alleviates Hypoxia-Induced Neurodevelopmental Abnormalities via PTEN/PI3K/AKT Signaling.
Du F, Bai Y, Bai K, Yang T, Chen J, Li T, Dai Y. Du F, et al. Int J Nanomedicine. 2026 May 13;21:604443. doi: 10.2147/IJN.S604443. eCollection 2026. Int J Nanomedicine. 2026. PMID: 42152976 Free PMC article.
RESULTS: In this study, we developed a transferrin-modified lipid nanoparticle system for non-invasive, transplacental delivery of HIF-1alpha small interfering RNA to the fetal brain, achieving a siRNA encapsulation efficiency of 84.18% and a loading capacity of 2.5%. Syst …
RESULTS: In this study, we developed a transferrin-modified lipid nanoparticle system for non-invasive, transplacental delivery of HIF-1alph …
Finite-Duration Venetoclax/Azacitidine Followed by Umbilical Cord Blood Infusion Improves Outcomes in Frail Elderly Patients With Untreated Acute Myeloid Leukemia-A Pilot Study.
Ye L, Xie M, Xu G, Mei C, Hu C, Zhou X, Ren Y, Ma L, Yang C, Qian J, Jin J, Tong H. Ye L, et al. Cancer Med. 2026 May;15(5):e71943. doi: 10.1002/cam4.71943. Cancer Med. 2026. PMID: 42152746 Free article.
BACKGROUND: Continuous venetoclax-azacitidine (VA) therapy is currently the major intervention for elderly or unfit acute myeloid leukemia (AML) patients. ...Induction and maintenance regimens were VA. Our consolidation therapy involved intravenous decitabine (20 mg …
BACKGROUND: Continuous venetoclax-azacitidine (VA) therapy is currently the major intervention for elderly or unfit acute myeloid leu …
The impact of second trimester detailed ultrasonography on anxiety and depression in high and low risk pregnancy.
Eser MD, Dogan Y. Eser MD, et al. BMC Pregnancy Childbirth. 2026 May 19. doi: 10.1186/s12884-026-09289-6. Online ahead of print. BMC Pregnancy Childbirth. 2026. PMID: 42151874 Free article.
METHODS: This observational prospective study included pregnant women admitted for second-trimester fetal anatomy screening. The patients were categorized into three groups based on their pregnancy risk status, low-risk, maternal-placental risk, or fetal risk. ...CO …
METHODS: This observational prospective study included pregnant women admitted for second-trimester fetal anatomy screening. The pati …
Advanced nanoformulations of NUAK1 regulate NLRP3 inflammasome for preeclampsia management in mice.
Jiang P, Ying X, Li Z, Fei W, Yao Y, Xu J, Li H, Chen L, Luo Q. Jiang P, et al. Nat Commun. 2026 May 18. doi: 10.1038/s41467-026-72775-0. Online ahead of print. Nat Commun. 2026. PMID: 42151142 Free article.
Preeclampsia (PE) is a severe pregnancy complication driven by placental dysfunction and oxidative stress, which currently lacks effective targeted therapies. Here, we evaluated the therapeutic potential of folic acid-modified lipid nanoparticles (NPs) co-loaded with polyd …
Preeclampsia (PE) is a severe pregnancy complication driven by placental dysfunction and oxidative stress, which currently lacks effective t …
Autophagy markers in umbilical cord blood-derived PBMCs and their association with preterm morbidities: a prospective multicenter cohort study.
Armağan C, Akyıldız C, Bakır G, Üçüncü Egeli T, Türe B, Erdoğan F, Taştan B, Engür D, Olukman Ö, Sütçüoğlu S, Uygur Ö, Gonülal D, Deliloğlu B, Duman N, Genç Ş, Özkan H. Armağan C, et al. BMJ Paediatr Open. 2026 May 18;10(1):e004363. doi: 10.1136/bmjpo-2025-004363. BMJ Paediatr Open. 2026. PMID: 42150845 Free PMC article.
Incidence and factors associated with neonatal hypoglycaemia in Chinese newborns delivered via caesarean section: a cross-sectional study.
Pu L, Yang Y, Shi J, Zhang Y, He L, Shen A, Wang C. Pu L, et al. BMJ Open. 2026 May 18;16(5):e101376. doi: 10.1136/bmjopen-2025-101376. BMJ Open. 2026. PMID: 42150835 Free PMC article.
CONCLUSIONS: Neonatal hypoglycaemia was common among Chinese newborns delivered via caesarean section, but most episodes were asymptomatic and resolved with routine feeding within 24 hours. Gestational age, fetal growth classification, elective caesarean delivery, parity a …
CONCLUSIONS: Neonatal hypoglycaemia was common among Chinese newborns delivered via caesarean section, but most episodes were asymptomatic a …
Multiscale modeling of blood circulation with cerebral autoregulation and network pathway analysis for hemodynamic redistribution in the vascular network with anatomical variations and stenosis conditions.
Liu J, Kanoke A, Endo H, Niizuma K, Suito H. Liu J, et al. PLoS Comput Biol. 2026 May 18;22(5):e1013853. doi: 10.1371/journal.pcbi.1013853. Online ahead of print. PLoS Comput Biol. 2026. PMID: 42149930 Free article.
Progressive stenosis modeling further demonstrated the transition from a complete CoW to a fetal-type posterior cerebral artery (PCA) configuration, with early ACoA flow reversal followed by the ipsilateral PCoA activation, in agreement with experimental and transcranial D …
Progressive stenosis modeling further demonstrated the transition from a complete CoW to a fetal-type posterior cerebral artery (PCA) …
A Novel Combination of Biallelic Variants in the VARS2 Gene: A Severe Phenotype.
Capela J, Reis M, Almeida I, Novo M, Ramalho A, Lipari P, Rodrigues M. Capela J, et al. Acta Med Port. 2026 May 18. doi: 10.20344/amp.23831. Online ahead of print. Acta Med Port. 2026. PMID: 42148851 Free article.
Both presented early hypertrophic cardiomyopathy and lactic acidosis, with fatal outcomes within the first year of life. The first also presented severe fetal growth restriction and a ventricular septal defect; the second developed epilepsy, respiratory failure, and psycho …
Both presented early hypertrophic cardiomyopathy and lactic acidosis, with fatal outcomes within the first year of life. The first also pres …
Refractory seizures as a manifestation of anti-epileptic drug induced hypocalcemia and vitamin D deficiency.
Gallucci A, Bolick J, Thelmo F. Gallucci A, et al. JCEM Case Rep. 2026 May 14;4(6):luag126. doi: 10.1210/jcemcr/luag126. eCollection 2026 Jun. JCEM Case Rep. 2026. PMID: 42147081 Free PMC article.
The patient was intubated and sedated and brought for emergency caesarean section due to persistent fetal decelerations in the setting of refractory status epilepticus. Laboratory investigations revealed a serum calcium level of 5.30 mg/dL (SI: 1.32 mmol/L) (reference rang …
The patient was intubated and sedated and brought for emergency caesarean section due to persistent fetal decelerations in the settin …
Metabolic maturity patterns in neonates: dissecting the interactive effects of gestational age and birth weight on metabolic profiles.
Tang H, Ma Y, Zhou Y, Yan H, Zhang H. Tang H, et al. Front Pediatr. 2026 May 1;14:1800632. doi: 10.3389/fped.2026.1800632. eCollection 2026. Front Pediatr. 2026. PMID: 42146933 Free PMC article.
CONCLUSION: Neonatal metabolic maturity is shaped by the synergistic interplay between intrauterine duration and fetal growth. The characteristic "high amino acid/low long-chain acylcarnitine" pattern observed in preterm infants, especially in those with lower birth weight …
CONCLUSION: Neonatal metabolic maturity is shaped by the synergistic interplay between intrauterine duration and fetal growth. The ch …
A Long-lived Avatar for Modeling Age-Related Vascular Disease.
Qin W, Tran TN, Xiao Y, Ta K, Kandel I, Kumar A, Pandey R, Dongchau BMA, Shah VV, Nguyen TKC, Carter KN, Brannan KW, Wang G, Jain A, Mojiri A, Cooke JP. Qin W, et al. bioRxiv [Preprint]. 2026 May 4:2026.04.29.721776. doi: 10.64898/2026.04.29.721776. bioRxiv. 2026. PMID: 42146676 Free PMC article. Preprint.
BACKGROUND: Current microphysiological models do not support long-term investigations into the chronic effects of vascular risk factors and the development of vascular diseases. Prolonged culture frequently leads to cellular senescence and loss of functional integrity, res …
BACKGROUND: Current microphysiological models do not support long-term investigations into the chronic effects of vascular risk factors and …
Compartment-specific soluble immune profiles associated with preterm birth, perinatal death, and low birthweight in pregnant individuals living with HIV.
Corry J, Zotova N, Tabala M, Kasindi FL, Massamba BL, Babakazo P, Manuzak JA, Liyanage NPM, Funderburg NT, Yotebieng M, Kwiek JJ. Corry J, et al. bioRxiv [Preprint]. 2026 May 6:2026.05.04.722284. doi: 10.64898/2026.05.04.722284. bioRxiv. 2026. PMID: 42146551 Free PMC article. Preprint.
BACKGROUND: Human immunodeficiency virus (HIV) infection in pregnancy is associated with preterm birth (PTB), low birthweight (LBW), and perinatal death (PND). Although antiretroviral therapy (ART) suppresses viral load it does not prevent HIV-associated adverse pregnancy …
BACKGROUND: Human immunodeficiency virus (HIV) infection in pregnancy is associated with preterm birth (PTB), low birthweight (LBW), and per …
Systemic lupus erythematosus in pregnancy: Maternal and fetal outcomes and management strategies (Review).
Omar I, Alakhras A, Ahmad M, Mutwali S. Omar I, et al. Med Int (Lond). 2026 May 6;6(4):35. doi: 10.3892/mi.2026.319. eCollection 2026 Jul-Aug. Med Int (Lond). 2026. PMID: 42145565 Free PMC article. Review.
Pregnancy in women with SLE is no longer considered uniformly prohibitive; however, it remains a high-risk clinical scenario due to maternal disease activity, lupus nephritis, antiphospholipid antibodies, chronic organ damage, and treatment-related factors that can adversely affe …
Pregnancy in women with SLE is no longer considered uniformly prohibitive; however, it remains a high-risk clinical scenario due to maternal …
Comparative study of oral iron and intravenous iron therapy in pregnancy induced anemia.
Khapre SS, Yograj S. Khapre SS, et al. Bioinformation. 2026 Mar 31;22(3):1655-1659. doi: 10.6026/973206300221655. eCollection 2026. Bioinformation. 2026. PMID: 42145415 Free PMC article.
Pregnancy-induced anemia, primarily caused by iron deficiency, poses significant risks to maternal and fetal health, especially in developing countries. Oral iron therapy is commonly used but has limitations due to poor compliance and gastrointestinal side effects. …
Pregnancy-induced anemia, primarily caused by iron deficiency, poses significant risks to maternal and fetal health, especially in de …
Prevalence of common respiratory viruses of infants with respiratory tract infections in European countries in the past decade: a systematic review and meta-analysis comparing between the pre-COVID-19, pandemic, and post-COVID-19 periods.
Mapindra MP, Mahindra MP, McNamara P, Kartasasmita C, Semple MG, Clark H, Madsen J. Mapindra MP, et al. Eur J Pediatr. 2026 May 16;185(6):401. doi: 10.1007/s00431-026-07065-4. Eur J Pediatr. 2026. PMID: 42142180 Free PMC article. Review.
WHAT IS KNOWN: The COVID-19 pandemic induced an infection precautions policy, which reduced the spread of respiratory infectious diseases. Respiratory Syncytial Virus (RSV) was estimated as one of the most common causes of respiratory infections in infants. Still, ther …
WHAT IS KNOWN: The COVID-19 pandemic induced an infection precautions policy, which reduced the spread of respiratory infectious diseas …
The in utero experience of NOD fetuses imprints disposition of B- and T-cell populations, autoantibody patterns, and diabetes development.
Renman E, Lejon K. Renman E, et al. Autoimmunity. 2026 Dec 31;59(1):2671674. doi: 10.1080/08916934.2026.2671674. Epub 2026 May 16. Autoimmunity. 2026. PMID: 42141919 Free article.
Maternal factors during fetal development may influence the onset and progression of autoimmune diseases such as type 1 diabetes (T1D). ...
Maternal factors during fetal development may influence the onset and progression of autoimmune diseases such as type 1 diabet …
Antenatal depressive symptoms impair offspring neurodevelopment by inducing maternal gut microbiota dysbiosis during pregnancy.
Zhou F, Wang L, Zhao Y, Hu C, Meng Y, Fan J, Fraser WD, Baillargeon JP, Ouyang F, Lye SJ, Dennis CL, Shen J, Wu Y, Huang H. Zhou F, et al. Gut Microbes. 2026 Dec 31;18(1):2672188. doi: 10.1080/19490976.2026.2672188. Epub 2026 May 15. Gut Microbes. 2026. PMID: 42141775 Free PMC article.
To establish causality, fecal microbiota transplantation (FMT) from women with AND symptoms was administered to germ-free dams, resulting in impaired intestinal barrier integrity, heightened neuroinflammatory signaling, and altered polyunsaturated fatty acid and amino acid metabo …
To establish causality, fecal microbiota transplantation (FMT) from women with AND symptoms was administered to germ-free dams, resulting in …
Melatonin Receptor Signaling in Human Pathologies: From Molecular Mechanisms to Therapeutic Targets.
Huang YS, Wu SD, Chen HC, Lu KC, Ka SM, Wu CC. Huang YS, et al. Function (Oxf). 2026 May 15. doi: 10.1152/function.011.2026. Online ahead of print. Function (Oxf). 2026. PMID: 42139078 Free article. Review.
We also discuss the clinical relevance of single nucleotide polymorphisms (SNPs) associated with the MTNR1A receptor and the range of diseases linked to its dysfunction. Current understanding and future perspectives regarding the gene regulation and stimulation of MTNR1A e …
We also discuss the clinical relevance of single nucleotide polymorphisms (SNPs) associated with the MTNR1A receptor and the range of dis …
The relationship of soluble urokinase plasminogen activator receptor levels with preterm premature rupture of membranes and predictive value in neonatal intensive care unit admission.
Koc BL, Tanacan A, Haliloglu E, Yilmaz HE, Ersak DT, Aktas BA, Kara O, Sahin D. Koc BL, et al. Rev Assoc Med Bras (1992). 2026 May 11;72(2):e20251351. doi: 10.1590/1806-9282.20251351. eCollection 2026. Rev Assoc Med Bras (1992). 2026. PMID: 42138934 Free PMC article.
Soluble urokinase plasminogen activator receptor has been described as a biomarker of infectious and inflammatory diseases. The aim of this study was to evaluate maternal serum soluble urokinase plasminogen activator receptor levels in pregnant women with preterm premature …
Soluble urokinase plasminogen activator receptor has been described as a biomarker of infectious and inflammatory diseases. The aim o …
Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia.
Puno A, Michno WP, Li L, Everitt A, McCluskey K, Htun S, Nagar D, Choi JB, Dai Y, Park S, Gurwitz E, Willsey JA, Birey F, Pasca AM. Puno A, et al. Elife. 2026 May 15;14:RP108134. doi: 10.7554/eLife.108134. Elife. 2026. PMID: 42138713 Free PMC article.
But when it came to testing in humans, therapies that looked promising in rodents failed to show benefit in patients, suggesting possible interspecies differences and the need to study human cells. ...They identify adrenomedullin as a potential target for developing effect …
But when it came to testing in humans, therapies that looked promising in rodents failed to show benefit in patients, suggesting poss …
MiR-21-5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression.
Krause BJ, Calle X, Kumar RV, Niu Y, Ramirez-Herrera O, Gonzalez D, Bernal B, Ford SG, Crew RC, Cochrane ALK, Arenas GA, Di Genova A, Giussani DA. Krause BJ, et al. Compr Physiol. 2026 Jun;16(3):e70173. doi: 10.1002/cph4.70173. Compr Physiol. 2026. PMID: 42138560 Free PMC article.
Fetal hypoxia is a common complication of pregnancy and increases the cardiovascular risk in offspring, contributing to a significant burden on life-long health. ...Since miRNA-21-5p downregulation contributes to fetal growth restriction (FGR) and cardiovascular imp …
Fetal hypoxia is a common complication of pregnancy and increases the cardiovascular risk in offspring, contributing to a significant …
In-utero cell transplantation for hypophosphatasia with gene-edited hESC-derived MSCs in a murine model.
Kitamura N, Hasegawa A, Takahashi-Nakamura A, Kasahara M, Akutsu H, Sago H, Samura O, Okamoto A, Umezawa A. Kitamura N, et al. Mol Ther Adv. 2026 Feb 13;34(2):201696. doi: 10.1016/j.omta.2026.201696. eCollection 2026 Jun 11. Mol Ther Adv. 2026. PMID: 42137584 Free PMC article.
We have developed an ex vivo in-utero gene cell therapy as a new treatment that can intervene at the fetal stage. We transduced the hALPL-D10 gene into human embryonic stem cell-derived mesenchymal stem cells to generate cells that overexpress TNAP. ...In addition, …
We have developed an ex vivo in-utero gene cell therapy as a new treatment that can intervene at the fetal stage. We transduce …
First-trimester free thyroxine as an independent predictor of gestational diabetes mellitus: a retrospective cohort study.
Do TTT, Le TT, Ho TTT, Vu LTN, Bui TC, Hoang HT. Do TTT, et al. Adv Lab Med. 2026 Apr 28;7(2):132-139. doi: 10.1515/almed-2026-0007. eCollection 2026 Jun. Adv Lab Med. 2026. PMID: 42136982 Free PMC article.
OBJECTIVES: Gestational diabetes mellitus (GDM) and thyroid dysfunction are two common endocrine diseases during pregnancy, both of which can adversely affect maternal and fetal health. ...
OBJECTIVES: Gestational diabetes mellitus (GDM) and thyroid dysfunction are two common endocrine diseases during pregnancy, both of w …
Efficacy and Safety of Thalidomidein Patients with Transfusion-Dependent B-Thalassemia: A Systematic Review, Meta-Analysis and GRADE Evaluation.
Li J, Ji P, Zhong Q, Dong L, Yi H, Chen B, Zhang X, Duan T. Li J, et al. Mediterr J Hematol Infect Dis. 2026 May 1;18(1):e2026033. doi: 10.4084/MJHID.2026.033. eCollection 2026. Mediterr J Hematol Infect Dis. 2026. PMID: 42136903 Free PMC article. Review.
BACKGROUND: The immunomodulatory drug thalidomide is a promising alternative therapy for transfusion-dependent beta-thalassemia (TDT) due to its potent induction of fetal hemoglobin. ...The meta-analysis of RCTs demonstrated that, compared with the control group, th …
BACKGROUND: The immunomodulatory drug thalidomide is a promising alternative therapy for transfusion-dependent beta-thalassemia (TDT) …
Coagulation function changes after high-intensity focused ultrasound therapy for uterine fibroids and adenomyosis: a large retrospective cohort study.
Zhang X, Ni J, Xu W, Bi R, Yang Y, Yang X, Lin B, Li H, Aili A, Li Z. Zhang X, et al. Int J Hyperthermia. 2026 Dec;43(1):2628224. doi: 10.1080/02656736.2026.2628224. Epub 2026 May 15. Int J Hyperthermia. 2026. PMID: 42136322 Free article.
OBJECTIVE: High-intensity focused ultrasound (HIFU) therapy is increasingly used in the management of various solid tumors. However, limited data are available regarding the association between HIFU treatment and coagulation function. MATERIALS AND METHODS: A total of 1,18 …
OBJECTIVE: High-intensity focused ultrasound (HIFU) therapy is increasingly used in the management of various solid tumors. However, …
Impact of leucine-rich diet on placenta's proteomic and metabolomic profiles of pregnant tumor-bearing rats.
Dos Santos IF, Salgado CM, Carregari VC, Dos Santos RW, de Souza DM, Viana LR, Gomes-Marcondes MCC. Dos Santos IF, et al. Cancer Biol Ther. 2026 Dec 31;27(1):2670792. doi: 10.1080/15384047.2026.2670792. Epub 2026 May 14. Cancer Biol Ther. 2026. PMID: 42135921 Free PMC article.
RESULTS: Tumor affected maternal weight, but leucine attenuated the decrease in placental weight and fetal resorption. Leucine supplementation restored the placental proteins involved in the nuclear structure, cytoskeleton, and immune response. ...CONCLUSION: A leucine-ric …
RESULTS: Tumor affected maternal weight, but leucine attenuated the decrease in placental weight and fetal resorption. Leucine supple …
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN-Digenic Myopathy.
Orbach R, Donkervoort S, Hedberg-Oldfors C, Baranello G, Saade D, D'Souza P, Patel R, Michael E, Foley AR, Bharucha-Goebel D, Haugland SJ, McAnally M, Hamid OA, Chao K, Macnamara EF, Beggs AH, Sarkozy A, Mueller J, Moore SA, Finkel RS, Tifft CJ, Muntoni F, Oldfors A, Bönnemann CG. Orbach R, et al. Ann Clin Transl Neurol. 2026 May 14. doi: 10.1002/acn3.70401. Online ahead of print. Ann Clin Transl Neurol. 2026. PMID: 42135902 Free article.
RESULTS: From the cohort of eight male patients (5-19 years at last evaluation), five presented prenatally with reduced fetal movements. At the time of birth, five had hypotonia, two had contractures, and two had respiratory distress. ...
RESULTS: From the cohort of eight male patients (5-19 years at last evaluation), five presented prenatally with reduced fetal movemen …
Reversible Sepsis-Induced Myocardial Dysfunction in Term Pregnancy: A Case Report of a Rare Medical Condition.
Balkan B, Gonulduru N, Kaya E, Yilmaz G. Balkan B, et al. Cureus. 2026 Apr 12;18(4):e106877. doi: 10.7759/cureus.106877. eCollection 2026 Apr. Cureus. 2026. PMID: 42131678 Free PMC article.
An emergency cesarean section was performed due to clinical deterioration of the mother and fetal distress. Postnatal echocardiography showed a left ventricular ejection fraction (LVEF) of 38% and global hypokinesia, but no apical ballooning or regional wall motion abnorma …
An emergency cesarean section was performed due to clinical deterioration of the mother and fetal distress. Postnatal echocardiograph …
Current Use and Barriers to POCUS in Women's Health: A National Survey of Veterans Affairs Medical Centers.
Gupta M, Hanson S, Wagner S, Shamshirsaz AA, Ranzini A, Mader MJ, Soni NJ. Gupta M, et al. POCUS J. 2026 May 11;11(1):104-109. doi: 10.24908/pocusj.v11i01.19484. eCollection 2026 May. POCUS J. 2026. PMID: 42131550 Free PMC article.
POCUS can be divided into gynecologic and obstetric applications-the latter can be further categorized into fetal POCUS and maternal POCUS. While fetal POCUS primarily assesses the fetus, maternal POCUS is crucial for evaluating conditions that impact a mother's hea …
POCUS can be divided into gynecologic and obstetric applications-the latter can be further categorized into fetal POCUS and maternal …
Diagnosis of a Right Congenital Diaphragmatic Hernia in a Neonate with POCUS.
DaVolio A, Hays BS, Thompson MO, Walsh MJ, Garg PM, Rodriguez RJ. DaVolio A, et al. POCUS J. 2026 May 11;11(1):121-125. doi: 10.24908/pocusj.v11i01.19486. eCollection 2026 May. POCUS J. 2026. PMID: 42131544 Free PMC article.
Point of care ultrasound (POCUS) can be used to diagnose neonatal lung diseases, especially in the setting of a newborn with significant respiratory distress. A neonate was born at 38.4 weeks gestational age to a 36-year-old Gravida 5 Para 3013 woman with prenatal concerns …
Point of care ultrasound (POCUS) can be used to diagnose neonatal lung diseases, especially in the setting of a newborn with signific …
Blood-based predictive biomarkers for preterm birth: Redefining risk stratification in modern perinatal care.
Andonotopo W, Bachnas MA, Dewantiningrum J, Pramono MBA, Sanjaya INH, Darmawan E, Aldiansyah D, Stanojevic M, Kurjak A. Andonotopo W, et al. Tzu Chi Med J. 2026 Jan 12;38(2):181-189. doi: 10.4103/tcmj.TCMJ-D-25-00042. eCollection 2026 Apr-Jun. Tzu Chi Med J. 2026. PMID: 42131411 Free PMC article. Review.
Spontaneous preterm birth (sPTB) remains a leading cause of neonatal morbidity and mortality worldwide, with current screening tools - such as cervical length measurement and fetal fibronectin - showing limited predictive value, particularly in asymptomatic women. ...Emerg …
Spontaneous preterm birth (sPTB) remains a leading cause of neonatal morbidity and mortality worldwide, with current screening tools - such …
Surgical Management of Pott's Paraplegia in a 27-Week Pregnant Woman with Continuation of Pregnancy: A Case Report.
Shaikh H, Chouhan A. Shaikh H, et al. J Orthop Case Rep. 2026 May;16(5):48-53. doi: 10.13107/jocr.2026.v16.i05.7200. J Orthop Case Rep. 2026. PMID: 42131035 Free PMC article.
INTRODUCTION: Spinal tuberculosis is primarily managed with antitubercular therapy, while surgical intervention is reserved for cases with neurological compromise or spinal instability. ...In view of acute neurological deterioration, urgent posterior decompression and stab …
INTRODUCTION: Spinal tuberculosis is primarily managed with antitubercular therapy, while surgical intervention is reserved for cases …
Prophylactic tranexamic acid for the prevention of postpartum haemorrhage in women with placenta praevia: multicentre, double blind, randomised, placebo controlled, phase 3 trial.
Zhang L, Bi S, Chen L, Du L, He F, Qiao Y, Li Z, Zeng W, Zhao X, Chen X, Li X, Ding G, Zhou W, Sun B, Guo Q, Guo X, Jin F, Wang X, Zhu Q, Sun Q, Jiang S, Wang X, Cai F, Jiang Y, Gao J, Wang Z, Wang Z, Zhang L, Liu JM, Huang L, Yu L, Chen J, Zhang S, Poon LC, Li HT, Chen D; study’s collaborator group. Zhang L, et al. BMJ. 2026 May 13;393:e089636. doi: 10.1136/bmj-2026-089636. BMJ. 2026. PMID: 42128454 Free PMC article. Clinical Trial.
Dysmorphological and Neuropsychological Phenotypes of Prenatally Alcohol-Exposed 6-Year-Old Children: A Prospective Longitudinal Birth Cohort Study.
Jolma M, Wallén E, Saure E, Rämö K, Kahila H, Kaminen-Ahola N. Jolma M, et al. Alcohol Clin Exp Res (Hoboken). 2026 May;50(5):e70320. doi: 10.1111/acer.70320. Alcohol Clin Exp Res (Hoboken). 2026. PMID: 42125938 Free PMC article.
BACKGROUND: Prenatal alcohol exposure (PAE) disrupts embryonic development, resulting in variable fetal alcohol spectrum disorder (FASD) phenotypes characterized by dysmorphological and neurodevelopmental abnormalities. ...RESULTS: Among the PAE group, 76% (19/25) of the c …
BACKGROUND: Prenatal alcohol exposure (PAE) disrupts embryonic development, resulting in variable fetal alcohol spectrum disorder (FA …
Maternal Nutrition During Pregnancy and Fetal Outcome, Short- and Long-Term Health Effects: A Narrative Review.
Capra ME, Bellani A, Berzieri M, Fradusco A, Esposito S, Biasucci G. Capra ME, et al. Nutrients. 2026 Apr 27;18(9):1375. doi: 10.3390/nu18091375. Nutrients. 2026. PMID: 42123976 Free PMC article. Review.
These observations led to the formulation of the Barker Hypothesis, which postulates that adverse nutritional exposures during fetal life can induce persistent physiological and metabolic adaptations, thereby increasing susceptibility to chronic diseases later in li …
These observations led to the formulation of the Barker Hypothesis, which postulates that adverse nutritional exposures during fetal …
PCYT1B-Targeting miRNAs as Potential Biomarkers for Placental Diseases.
Shin HE, Seok J, Kim JY, Cha DH, Shin JS, Kim GJ. Shin HE, et al. Int J Mol Sci. 2026 Apr 30;27(9):4039. doi: 10.3390/ijms27094039. Int J Mol Sci. 2026. PMID: 42123616 Free PMC article.
Obstetrical diseases are complications associated with pregnancy or childbirth that can cause maternal sequelae and fetal complications. ...However, reliable diagnostic markers and therapeutic strategies for obstetrical diseases remain limited. The aim of thi …
Obstetrical diseases are complications associated with pregnancy or childbirth that can cause maternal sequelae and fetal comp …
Inflammation at the Maternal-Fetal Interface: Mechanisms Linking Maternal-Fetal Immunity to Preeclampsia and Fetal Growth Restriction.
Miranda J, Maestre N, Devia M, Zapata R, Ochoa-Díaz MM, Annicchiarico W. Miranda J, et al. Int J Mol Sci. 2026 Apr 29;27(9):3954. doi: 10.3390/ijms27093954. Int J Mol Sci. 2026. PMID: 42123539 Free PMC article. Review.
This review, therefore, focuses on how immune dysregulation contributes to placental dysfunction in preeclampsia and FGR, synthesizing current knowledge of the maternal-fetal immune interface and exploring therapeutic strategies that link pathogenic mechanisms to targeted …
This review, therefore, focuses on how immune dysregulation contributes to placental dysfunction in preeclampsia and FGR, synthesizing curre …
Common Biomarkers of Endothelial Dysfunction Across Highly Prevalent Diseases with Cardiovascular Risk: Functional Characterization and Prognostic Implications.
Martinez-Sanchez J, Torramadé-Moix S, Moreno-Castaño AB, Lafoz E, Rovira J, Diekmann F, Rodas LM, Cuadrado-Payán E, Galceran I, Cases A, Dantas AP, Barberà JA, Tura-Ceide O, Crispi F, Gratacós E, García-Calderó H, García-Pagán JC, Hernández-Gea V, Escolar G, Pereira A, Diaz-Ricart M. Martinez-Sanchez J, et al. Int J Mol Sci. 2026 Apr 25;27(9):3829. doi: 10.3390/ijms27093829. Int J Mol Sci. 2026. PMID: 42123411 Free PMC article.
For serum ED biomarkers, 18 metabolites and 24 proteins showed AUC-ROC and hit rates >77.5%, and six metabolites were associated with event-free survival. These diseases share ED driven by systemic inflammatory, oxidative, and metabolic stress, are partially reversible …
For serum ED biomarkers, 18 metabolites and 24 proteins showed AUC-ROC and hit rates >77.5%, and six metabolites were associated with eve …
Altered Lipid Profile and Oxidative Stress During Pregnancy: Impact on the Fetus and Risk of Metabolic Disorders in Adulthood.
Jovanovic K, Jovandaric MZ, Jovanovic D, Milincic M, Krstic M, Cegar B, Nikolic DM. Jovanovic K, et al. Int J Mol Sci. 2026 Apr 23;27(9):3744. doi: 10.3390/ijms27093744. Int J Mol Sci. 2026. PMID: 42123329 Free PMC article. Review.
This review aims to evaluate mechanistic pathways linking maternal lipid metabolism, oxidative stress, placental function, and fetal organ remodeling. Mechanistic and translational studies were identified through searches of PubMed, Scopus, the Cochrane Library, and Web of …
This review aims to evaluate mechanistic pathways linking maternal lipid metabolism, oxidative stress, placental function, and fetal …
Seroprevalence of anti-Toxoplasma antibodies among hospitalized newborns and their mothers: associated factors and maternal awareness in a cross-sectional study in Yasuj, Iran.
Arefkhah N, Zeinipour A, Moshfe A, Omidian M, Omidian M. Arefkhah N, et al. BMC Pregnancy Childbirth. 2026 May 13. doi: 10.1186/s12884-026-09226-7. Online ahead of print. BMC Pregnancy Childbirth. 2026. PMID: 42121106 Free article.
BACKGROUND: Toxoplasma gondii is a major congenital parasitic pathogen that can be transmitted vertically and is associated with a wide spectrum of adverse fetal and neonatal outcomes. In Iran, data on concurrent maternal-neonatal serological assessments remain limited, pa …
BACKGROUND: Toxoplasma gondii is a major congenital parasitic pathogen that can be transmitted vertically and is associated with a wide spec …
Clinical outcomes and practical management implications in rudimentary horn pregnancies: a systematic review and pooled analysis (2010-2025).
Emrich NLA, Padrón LT, Schröder C, Mustea A, Strizek B, Gembruch U, Cruz JJ. Emrich NLA, et al. Arch Gynecol Obstet. 2026 May 12;313(1):194. doi: 10.1007/s00404-026-08455-7. Arch Gynecol Obstet. 2026. PMID: 42118334 Free PMC article. Review.
PURPOSE: Rudimentary horn pregnancies are rare and carry significant maternal and fetal risks. This study aims to systematically review published cases of rudimentary horn pregnancies describing data about time of diagnosis, time of rupture, and live birth rate (LBR), with …
PURPOSE: Rudimentary horn pregnancies are rare and carry significant maternal and fetal risks. This study aims to systematically revi …
Continuous persistent occiput transverse position during labor - associations of different midwifery interventions with cervical dilation rate and birth outcomes: A retrospective cohort study.
Jiang M, Zheng M. Jiang M, et al. Medicine (Baltimore). 2026 May 8;105(19):e48574. doi: 10.1097/MD.0000000000048574. Medicine (Baltimore). 2026. PMID: 42116384 Free PMC article.
Persistent occiput transverse (OT) position during active labor can impede effective fetal descent and rotation, increasing the likelihood of labor dystocia and operative birth. ...
Persistent occiput transverse (OT) position during active labor can impede effective fetal descent and rotation, increasing the likel …
Maternal nutritional depletion and inflammatory stress in late-onset fetal growth restriction: Rethinking hemogram-derived indices for clinical dietary counseling.
Güler AE, Çakir A. Güler AE, et al. Medicine (Baltimore). 2026 May 8;105(19):e48597. doi: 10.1097/MD.0000000000048597. Medicine (Baltimore). 2026. PMID: 42116373 Free PMC article.
Fetal growth restriction (FGR) is a multifactorial condition involving placental dysfunction and maternal systemic stress. ...Women with abdominal circumference and/or estimated fetal weight < 3rd percentile between 34 to 37 weeks were included as late-onset FGR. …
Fetal growth restriction (FGR) is a multifactorial condition involving placental dysfunction and maternal systemic stress. ...Women w …
Leiomyosarcoma of uterus in pregnancy: A case report.
Lin M, Chen C, Wu X, Lin H, Lin Y, Lin J. Lin M, et al. Medicine (Baltimore). 2026 May 8;105(19):e48608. doi: 10.1097/MD.0000000000048608. Medicine (Baltimore). 2026. PMID: 42116313 Free PMC article.
Due to the large tumor size, which affected fetal delivery and incision closure, she underwent cesarean section combined with myomectomy. ...
Due to the large tumor size, which affected fetal delivery and incision closure, she underwent cesarean section combined with myomect …
Physical activity levels and their multilevel determinants in pregnant women screened for contraindications: a cross-sectional study in Shanghai, China.
Wang X, Wang X, Xu F, Wang J, Dai Y, Sun L, Tao H, Gu C. Wang X, et al. BMC Public Health. 2026 May 11. doi: 10.1186/s12889-026-27663-z. Online ahead of print. BMC Public Health. 2026. PMID: 42116073 Free article.
RESULTS: The two-stage screening identified 127 women (15.47%) with contraindications: 29 (3.53%) with absolute contraindications (including severe respiratory, cardiovascular, or systemic diseases, fetal growth restriction, unexplained persistent vaginal bleeding, …
RESULTS: The two-stage screening identified 127 women (15.47%) with contraindications: 29 (3.53%) with absolute contraindications (including …
A new 308 A-G substitution in HBG2 in an acyanotic newborn: case report.
Pellicani S, Capozza M, Andolfo I, Russo R, Iolascon A, Laforgia N. Pellicani S, et al. Ital J Pediatr. 2026 May 11. doi: 10.1186/s13052-026-02275-w. Online ahead of print. Ital J Pediatr. 2026. PMID: 42116066 Free article.
The infant exhibited no signs of respiratory distress and normal blood gas analysis, but pulse oximetry revealed persistent arterial oxygen saturation of 88% in room air. Supplemental oxygen therapy (FiO2 23%) was initiated, resulting in a gradual improvement in saturation …
The infant exhibited no signs of respiratory distress and normal blood gas analysis, but pulse oximetry revealed persistent arterial oxygen …
More disease-modifying therapies for sickle cell disease: Are small molecules and drug repurposing the way forward?
Quinn CT. Quinn CT. Semin Hematol. 2026 Apr 15:S0037-1963(26)00026-0. doi: 10.1053/j.seminhematol.2026.04.001. Online ahead of print. Semin Hematol. 2026. PMID: 42115086 Free article.
Despite advances in understanding the molecular and cellular pathophysiology of sickle cell disease (SCD), the development of effective pharmacologic therapies has been slow. Hydroxyurea, a small molecule repurposed decades ago, remains the cornerstone of disease-modifying …
Despite advances in understanding the molecular and cellular pathophysiology of sickle cell disease (SCD), the development of effective phar …
Mapping the evidence on stillbirth prevention across the reproductive continuum: an umbrella review.
Gadapani Pathak B, Vats P, Manna S, Yadav S, Bhatt A, Mukherjee R, Patil R, Dayma G, Mazumder S. Gadapani Pathak B, et al. BMJ Open. 2026 May 11;16(5):e110895. doi: 10.1136/bmjopen-2025-110895. BMJ Open. 2026. PMID: 42114873 Free PMC article.
ELIGIBILITY CRITERIA: Systematic reviews and meta-analyses synthesising randomised controlled trials or quasi-experimental studies that reported stillbirth, perinatal mortality, fetal loss or fetal death were included. Reviews focused exclusively on predefined high- …
ELIGIBILITY CRITERIA: Systematic reviews and meta-analyses synthesising randomised controlled trials or quasi-experimental studies that repo …
The Value of Anti-Drug Antibody Detection in Discriminating Patients from Healthy Controls and Predicting the Gross Motor Functional State in Patients with Pompe Disease.
Aziz-Ahari S, Aminian M, Rahimian A, Nafissi S, Heidari M, Rabbani A, Zarnani AH, Mohebbi A, Badv RS, Salajegheh N, Mortezagholi S, Masoumi S, Hadipour Z, Boostani R, Beiraghi Toosi M, Sayadpour Zanjani K, Khajeh A, Tonkaboni SH, Sadeghi M, Fatehi F, Vafaei E, Ashrafi MR. Aziz-Ahari S, et al. Iran J Allergy Asthma Immunol. 2026 Feb 1;25(2):212-221. doi: 10.18502/ijaai.v25i2.20800. Iran J Allergy Asthma Immunol. 2026. PMID: 42113496 Free article.
Anti-recombinant human acid alpha-glucosidase (anti-rhGAA) antibody formation is a major challenge in patients with Pompe disease receiving enzyme replacement therapy (ERT). The clinical significance of these antibodies and their detection methods remain uncertain. ...
Anti-recombinant human acid alpha-glucosidase (anti-rhGAA) antibody formation is a major challenge in patients with Pompe disease receiving …
Photobiomodulation in acute rejection of fetal intestinal grafts: morphological aspects and lymphocyte activation.
Honório S, Barbosa Carvalho P, Cristine de Souza Almeida R, Evangelista Alves Costa A, de Fátima Jacysyn J, Kiyomi Koike M, Russo Costa do Bomfim F, Frasson de Souza Montero E. Honório S, et al. Lasers Med Sci. 2026 May 11;41(1):90. doi: 10.1007/s10103-026-04883-8. Lasers Med Sci. 2026. PMID: 42113271 Free PMC article.
This study aimed to evaluate the effects of PBM on fetal intestinal transplantation in mice. The study was conducted in two phases. In the first phase, 77 mice were utilized to assess histological outcomes. Fetal intestines from pregnant C57BL/6 mice were transplan …
This study aimed to evaluate the effects of PBM on fetal intestinal transplantation in mice. The study was conducted in two phases. …
In Vitro Antidiabetic Activity and Mechanism of Action of Methanolic Extract of Opuntia stricta Cladodes.
Kampamba M, Ezeala CC, Zombe K, Bwalya AG. Kampamba M, et al. Biomed Res Int. 2026;2026(1):e9325356. doi: 10.1155/bmri/9325356. Biomed Res Int. 2026. PMID: 42113019 Free PMC article.
In INS-1 beta-cells, proliferation increased at 125 mug/mL after 24 h compared to untreated (111.8% 2.2% vs. 100.0% 3.8%, p < 0.001), exceeding 10% fetal bovine serum (FBS) (97.8% 4.1%) but declined significantly at 48 and 72 h (p < 0.05). ...

In INS-1 beta-cells, proliferation increased at 125 mug/mL after 24 h compared to untreated (111.8% 2.2% vs. 100.0% 3.8%, p < 0.001),

…
Atorvastatin as a pleiotropic anticancer agent: mechanisms, evidence, and therapeutic repurposing potential.
Su J, Ji C, Niu X, Wu Z, Shi L, Kang L, Li D, Ma Y, Pang G, Ma X, Zhou CM, Jiang X, Pang B. Su J, et al. Front Immunol. 2026 Apr 24;17:1808729. doi: 10.3389/fimmu.2026.1808729. eCollection 2026. Front Immunol. 2026. PMID: 42112329 Free PMC article. Review.
Accumulating preclinical and clinical evidence suggests that ATV possesses significant anticancer properties beyond its lipid-lowering effects, positioning it as a promising candidate for adjunctive cancer therapy. The anticancer efficacy of ATV stems fundamentally from it …
Accumulating preclinical and clinical evidence suggests that ATV possesses significant anticancer properties beyond its lipid-lowering effec …
Engineered artificial antigen-presenting cells for tumor immunotherapy: Design strategies, clinical applications, and translational challenges.
Cai H, Zhao Y, Cai Y, Luo X, Li J, Wu Y, Yang J, Wang C, Zhang Y, Ding H, Cheng S, Wang Y. Cai H, et al. Mater Today Bio. 2026 May 2;38:103192. doi: 10.1016/j.mtbio.2026.103192. eCollection 2026 Jun. Mater Today Bio. 2026. PMID: 42111759 Free PMC article. Review.
Immunotherapy has long played a pivotal role in cancer treatment, and antigen-presenting cell (APC)-based immunotherapy represents a promising strategy, though its full potential remains to be realized. This therapy stimulates T cell activation and proliferation through AP …
Immunotherapy has long played a pivotal role in cancer treatment, and antigen-presenting cell (APC)-based immunotherapy represents a promisi …
A clinical conceptual framework for testing and designing neuromotor rehabilitation programs in individuals with Bainbridge Ropers syndrome: a perspective study.
Yaddanapudi S, Quach PTM, Villanueva J, McGregor K, Brady A, Singh H. Yaddanapudi S, et al. Front Neurol. 2026 Apr 24;17:1692574. doi: 10.3389/fneur.2026.1692574. eCollection 2026. Front Neurol. 2026. PMID: 42111080 Free PMC article.
The Additional Sex Combs Like gene (ASXL) encodes a group of transcriptional regulator proteins that bind to chromatin primarily during fetal development. Mutation of the third transcription factor from this gene (ASXL-3) is responsible for the clinical condition of Bainbr …
The Additional Sex Combs Like gene (ASXL) encodes a group of transcriptional regulator proteins that bind to chromatin primarily during f …
Management and treatment of breast cancer in pregnant women.
Mielniczek K, Leśniewska M, Chawrylak K, Pelc Z, Sędłak K, Polkowski WP, Rawicz-Pruszyński K. Mielniczek K, et al. Arch Med Sci. 2025 Apr 20;22(1):1-11. doi: 10.5114/aoms/196998. eCollection 2026 Jan. Arch Med Sci. 2025. PMID: 42110629 Free PMC article.
Hormone therapy should not be used during pregnancy as it may affect the fetus. Studies suggest that estrogen or progestogen therapy during pregnancy may cause malformations in children exposed in utero. One known phenomenon is the congenital fetal defect Gol …
Hormone therapy should not be used during pregnancy as it may affect the fetus. Studies suggest that estrogen or progestogen thera …
Vagus nerve stimulation as an anti-inflammatory therapy for maternal immune activation-induced alterations in offspring microglia and neurodevelopment.
Gargus M, Poyhia L, Errico JP, Rogers MKN, Tremblay ME. Gargus M, et al. Front Neurosci. 2026 Apr 24;20:1827714. doi: 10.3389/fnins.2026.1827714. eCollection 2026. Front Neurosci. 2026. PMID: 42110197 Free PMC article. Review.
These cytokines can be produced in the maternal periphery and placenta, leading to the transmission of maternal cytokines into the fetal brain and causing upregulation of endogenous production. In the fetal brain, IL-6 and IL-17a act on microglia, the innate immune …
These cytokines can be produced in the maternal periphery and placenta, leading to the transmission of maternal cytokines into the fetal …
DNA Methylation and Fetal Programming of Cardiovascular Disease: From Congenital Heart Diseases to Adult Cardiovascular Dysfunction.
Chen Z, Qiu M, Li Y, Xie W, Chen T, Qiu H, Zhang Y, Wen S. Chen Z, et al. Rev Cardiovasc Med. 2026 Apr 2;27(4):46174. doi: 10.31083/RCM46174. eCollection 2026 Apr. Rev Cardiovasc Med. 2026. PMID: 42110157 Free PMC article. Review.
DNA methylation, the most extensively studied epigenetic mechanism, acts as a critical interface between maternal environmental influences and fetal cardiovascular development. During embryogenesis, tightly orchestrated methylation remodeling regulates the transcriptional …
DNA methylation, the most extensively studied epigenetic mechanism, acts as a critical interface between maternal environmental influences a …
Cross-ancestry analysis of gestational diabetes mellitus identifies novel loci, drug targets and biological pathways.
Zhao W, Hu H, Li M, Liu L, Peng W, Chu Y. Zhao W, et al. Front Endocrinol (Lausanne). 2026 Apr 23;17:1718746. doi: 10.3389/fendo.2026.1718746. eCollection 2026. Front Endocrinol (Lausanne). 2026. PMID: 42109742 Free PMC article.
BACKGROUND: Gestational diabetes mellitus (GDM) is a common pregnancy complication with adverse maternal and fetal outcomes, yet its genetic basis is not fully understood. Previous genome-wide association studies (GWAS) have identified only a limited number of susceptibili …
BACKGROUND: Gestational diabetes mellitus (GDM) is a common pregnancy complication with adverse maternal and fetal outcomes, yet its …
Neonatal and Pregnancy Outcomes in Pregnant Adults With Pediatric-Onset Crohn's Disease.
Swamy S, Achkar JP, Ehrenberg S, Zajichek A, Milinovich A, Shah RS, Barry J, Kim SC, Kurowski JA. Swamy S, et al. Gastro Hep Adv. 2026 Apr 7;5(6):100959. doi: 10.1016/j.gastha.2026.100959. eCollection 2026. Gastro Hep Adv. 2026. PMID: 42109271 Free PMC article.
A CD flare during pregnancy resulted in a 10.9% reduction in BW percentile at delivery (95% CI: -20.05 to -1.64). Antitumor necrosis factor therapy at the time of conception was associated with an 8.7% increase in BW percentiles (95% CI: 1.13-16.27). ...Longer disease dura …
A CD flare during pregnancy resulted in a 10.9% reduction in BW percentile at delivery (95% CI: -20.05 to -1.64). Antitumor necrosis factor …
Dexamethasone affects the circadian clock in the fetal mouse suprachiasmatic nucleus at the transcriptional level.
Sládek M, Cadenato P, Semenovykh K, Houdek P, Sumová A. Sládek M, et al. Biomed Pharmacother. 2026 May 9;199:119486. doi: 10.1016/j.biopha.2026.119486. Online ahead of print. Biomed Pharmacother. 2026. PMID: 42107912 Free article.
Dexamethasone (DEX) is used in clinical practice as a life-saving therapy in threatened preterm birth; however, such treatment also represents a powerful signal that can reprogram fetal physiology, including the circadian system. ...We demonstrate that GRs are homog …
Dexamethasone (DEX) is used in clinical practice as a life-saving therapy in threatened preterm birth; however, such treatment also r …
LNGFR promoting osteogenic differentiation of ectomesenchyme stem cells via activation of GHR-JAK-STAT/IGF1 signaling pathway.
Wang K, Zeng X, Zhang Y, Zou Y, Ye J, Zhao Y, Jin H, Zhang J, Nie X, Cheng G. Wang K, et al. Stem Cell Res Ther. 2026 May 9. doi: 10.1186/s13287-026-05052-y. Online ahead of print. Stem Cell Res Ther. 2026. PMID: 42106838 Free article.
Furthermore, impaired skeletal development and reduced mineralization were observed in lngfr(-/-) fetal mice in vivo. Circular RNA (circRNA) sequencing identified the growth hormone (GH) pathway as a key factor involved in LNGFR-regulated osteogenesis of EMSCs. ...
Furthermore, impaired skeletal development and reduced mineralization were observed in lngfr(-/-) fetal mice in vivo. Circular RNA (c …
Functional analysis of a novel splice site variant of RAB3GAP2 in a fetus with congenital cataracts.
Tan X, Huang Y, Wei X, Lai Q, Pang L, Lan J, Liu Q, Qin J, Zeng F, Chen L, Yuan D. Tan X, et al. BMC Med Genomics. 2026 May 9. doi: 10.1186/s12920-026-02385-8. Online ahead of print. BMC Med Genomics. 2026. PMID: 42106822 Free article.
This study aimed to assess the pathogenicity of the RAB3GAP2 variant c.304 + 5G > T. METHODS: Fetal lenses were evaluated using ultrasound. Whole exome sequencing (WES) was employed to identify splicing variants in RAB3GAP2, and Sanger sequencing confirmed the results. …
This study aimed to assess the pathogenicity of the RAB3GAP2 variant c.304 + 5G > T. METHODS: Fetal lenses were evaluated using ul …
Thyroid function changes in pregnant women with thyroid cancer and their association with adverse fetal outcomes: a parallel controlled study.
Hua ZF, Chen J, Wu JN, Peng T. Hua ZF, et al. BMC Pregnancy Childbirth. 2026 May 9. doi: 10.1186/s12884-026-09222-x. Online ahead of print. BMC Pregnancy Childbirth. 2026. PMID: 42106713 Free article.
BACKGROUND: The effects of thyroid hormone replacement or suppression therapy in women with thyroid cancer on thyroid function during pregnancy and subsequent adverse fetal outcomes are still largely unknown. To compare thyroid function at 8 weeks of gestation and i …
BACKGROUND: The effects of thyroid hormone replacement or suppression therapy in women with thyroid cancer on thyroid function during …
Sex-specific associations of sedentary behaviour and physical activity with placental and fetal IL-6 in pregnant women with obesity. Impact on neonatal adiposity in the DALI randomised controlled trial.
Acosta-Manzano P, Hill DJ, Leopold-Posch B, Desoye G, van Poppel MNM; DALI core investigator group. Acosta-Manzano P, et al. Diabetes Res Clin Pract. 2026 May 7;237:113292. doi: 10.1016/j.diabres.2026.113292. Online ahead of print. Diabetes Res Clin Pract. 2026. PMID: 42105870 Free article.
Higher placental IL-6 expression is linked to reduced fetal insulinemia and insulin resistance, contributing to lower neonatal adiposity. TWITTER SUMMARY/SOCIAL MEDIA: In pregnant women with obesity, higher moderate-vigorous physical activity and lower sedentary time upreg …
Higher placental IL-6 expression is linked to reduced fetal insulinemia and insulin resistance, contributing to lower neonatal adipos …
Stem cell-based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection.
Li Z, Kang Y, Niu Y. Li Z, et al. Animal Model Exp Med. 2026 May 9. doi: 10.1002/ame2.70211. Online ahead of print. Animal Model Exp Med. 2026. PMID: 42104727 Free article. Review.
Of particular concern, immune rejection remains a critical barrier even after the transplantation of autologous SC-islets, necessitating continued reliance on immunosuppressive therapy. Cell encapsulation and gene editing strategies have emerged as potential approaches to …
Of particular concern, immune rejection remains a critical barrier even after the transplantation of autologous SC-islets, necessitating con …
Referral linkages to support pregnant and postpartum individuals with opioid use disorders in Florida: a social network analysis.
Ratta AK, Elger RS, Vermeer W, Wright T, Oxner A, Fryer K, Marshall J. Ratta AK, et al. Addict Sci Clin Pract. 2026 May 8;21(1):42. doi: 10.1186/s13722-026-00675-1. Addict Sci Clin Pract. 2026. PMID: 42104470 Free PMC article.
CADENCE clinics were inter-linked; CADENCE Co-located pediatric/ psychiatric/Maternal-Fetal Medicine clinic was most connected (38 ties), followed by CADENCE Outpatient Prenatal Care clinic (16 ties), and CADENCE Addiction Medicine (9 ties). ...
CADENCE clinics were inter-linked; CADENCE Co-located pediatric/ psychiatric/Maternal-Fetal Medicine clinic was most connected (38 ti …
A systematic review of couple- or household-targeted interventions for smoking cessation in pregnancy.
Mullin S, Burden C, Grant K, Merriel A, Davies A. Mullin S, et al. BMC Public Health. 2026 May 8. doi: 10.1186/s12889-026-27484-0. Online ahead of print. BMC Public Health. 2026. PMID: 42104326 Free article.
They included behavioural support (n = 6 women, n = 4 partners), written or self-help materials (n = 4 women, n = 6 partners), nicotine replacement therapy (n = 1 women, n = 1 partners), demonstration of smoking effects on the fetal heart (n = 1 women) and incentive …
They included behavioural support (n = 6 women, n = 4 partners), written or self-help materials (n = 4 women, n = 6 partners), nicotine repl …
Cross-species insights into placental evolution and diseases at the single-cell resolution.
Tan G, Zhang A, Cao X, Yang J, Cui Y, Wang F, Shi T, Li H, Wang H, Shan H, Ren J, Zhou Y, Wang M, Luo F, Guo X, Huo W, Liu Y, Niyazbekova Z, Wang X, Xiao Z, Zheng Y, Jiang Y. Tan G, et al. Nat Commun. 2026 May 9. doi: 10.1038/s41467-026-72652-w. Online ahead of print. Nat Commun. 2026. PMID: 42103736 Free article.
The placenta is essential for fetal development, yet its molecular evolution across mammals remains elusive. Here, we present a comprehensive single-cell transcriptomic atlas of ~300,000 cells from ten species representing the four primary placental types: discoid, cotyled …
The placenta is essential for fetal development, yet its molecular evolution across mammals remains elusive. Here, we present a compr …
Maternal RSV vaccination generates high-affinity antibodies that efficiently transfer to infants, providing enhanced passive immunity.
Liu D, Posadas O, Mishra AK, Mire MM, Pike M, Englund JA, Kachikis A, Khurana S. Liu D, et al. Nat Commun. 2026 May 8. doi: 10.1038/s41467-026-72659-3. Online ahead of print. Nat Commun. 2026. PMID: 42103721 Free article.
A bivalent pre-fusion (preF) protein RSV vaccine was licensed for pregnant persons in 2023 (Abrysvo, Pfizer), but the impact of RSV maternal immunization on maternal-fetal immunity has not been well characterized. We analyze neutralizing antibody responses, binding antibod …
A bivalent pre-fusion (preF) protein RSV vaccine was licensed for pregnant persons in 2023 (Abrysvo, Pfizer), but the impact of RSV maternal …
Risk factors and population attributable fraction for large-for-gestational-age and macrosomic births in low- and middle-income countries between 2000 and 2025: a protocol for systematic review and meta-analysis.
Kirakoya-Samadoulougou F, Blencowe H, Ilboudo D, Ukwishaka J, Suarez Idueta L, Hazel EA, Ohuma E, Erchick DJ, Katz J, Lee AC, Black RE. Kirakoya-Samadoulougou F, et al. BMJ Open. 2026 May 8;16(5):e110407. doi: 10.1136/bmjopen-2025-110407. BMJ Open. 2026. PMID: 42103388 Free PMC article.
Targeting Hyperoxia-Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants.
Koloko Ngassie ML, Drake LY, Zhu Y, Ortiz Y, Pfeffer-Kleemann DA, Thompson MA, Hamrick SK, Pabelick CM, Prakash YS. Koloko Ngassie ML, et al. Aging Cell. 2026 May;25(5):e70538. doi: 10.1111/acel.70538. Aging Cell. 2026. PMID: 42101153 Free PMC article.
Supplemental oxygen (hyperoxia), often provided to premature infants, can disrupt lung growth and contribute to development of neonatal and pediatric lung diseases, necessitating understanding of underlying mechanisms. We previously showed that even moderate hyperoxia (&lt …
Supplemental oxygen (hyperoxia), often provided to premature infants, can disrupt lung growth and contribute to development of neonatal and …
Cardiometabolomic signatures and gut microbiota dynamics in perinatally undernourished F1 offspring: Decoding the metabolic footprint.
Ranade AV, Hegde PS, Agni MB, Rai P, Upadhyay SS, Aravind A, Keshava Prasad TS, Gowda KMD. Ranade AV, et al. J Biosci. 2026;51:19. J Biosci. 2026. PMID: 42100978 Free article.
Perinatal undernutrition, an important concern during fetal development, may affect growth and metabolic programming, resulting in lasting health implications. Maternal nutrition is crucial in modulating fetal endocrine systems and metabolic functions, influencing t …
Perinatal undernutrition, an important concern during fetal development, may affect growth and metabolic programming, resulting in la …
ASF1B promotes erythropoiesis by regulating the establishment and enrichment of H3.3 nucleosomes.
Liu J, Song X, Zhou L, Zhao Y, Kim J, Li J, Dean A, Guo X. Liu J, et al. Nucleic Acids Res. 2026 May 5;54(9):gkag447. doi: 10.1093/nar/gkag447. Nucleic Acids Res. 2026. PMID: 42100853 Free PMC article.
We found that the expression of ASF1B was abundant together with histone variant H3.3 during in mouse fetal liver cells. However, the mechanism underlying this coordination is still unclear. ...However, loss of ASF1B de-repressed the expression of embryonic/fetal gl …
We found that the expression of ASF1B was abundant together with histone variant H3.3 during in mouse fetal liver cells. However, the …
Opioid analgesic use during pregnancy: a drug utilization cohort study in Catalonia.
Driessen V, Camacho-Arteaga L, Giner-Soriano M, Bellas L, Agustí A. Driessen V, et al. Front Pharmacol. 2026 Apr 22;17:1804898. doi: 10.3389/fphar.2026.1804898. eCollection 2026. Front Pharmacol. 2026. PMID: 42100322 Free PMC article.
BACKGROUND: The increasing use of opioids during pregnancy and their potential adverse effects on fetal development have raised public health concerns. This study aimed to investigate the opioid prescribing patterns among pregnant women in Catalonia, Spain. ...We also exam …
BACKGROUND: The increasing use of opioids during pregnancy and their potential adverse effects on fetal development have raised publi …
Echocardiographic strain as an ally in the evaluation of congenital heart disease: a narrative review.
Alvarez Alarcón YL, Montaña-Jimenez LP. Alvarez Alarcón YL, et al. Front Cardiovasc Med. 2026 Apr 22;13:1662430. doi: 10.3389/fcvm.2026.1662430. eCollection 2026. Front Cardiovasc Med. 2026. PMID: 42099792 Free PMC article. Review.
INTRODUCTION: Congenital heart diseases (CHDs) are the most common congenital malformations in newborns and are associated with significant long-term cardiac morbidity. ...RV longitudinal strain and atrial strain have shown prognostic value in early dysfunction and adverse …
INTRODUCTION: Congenital heart diseases (CHDs) are the most common congenital malformations in newborns and are associated with signi …
Integrative circulatory engineering for regenerative therapy: Dynamic perfusion design and metabolic maturation in cardiac tissue engineering.
Homma J, Sekine H. Homma J, et al. Regen Ther. 2026 May 2;32:101123. doi: 10.1016/j.reth.2026.101123. eCollection 2026 Jun. Regen Ther. 2026. PMID: 42099747 Free PMC article.
By contrast, current cardiac tissue engineering platforms, including scaffold-free myocardial constructs, have achieved robust contraction and basic drug responsiveness but remain constrained by fetal-like cardiomyocyte metabolism and incomplete vascular integration. As pl …
By contrast, current cardiac tissue engineering platforms, including scaffold-free myocardial constructs, have achieved robust contraction a …
Expression of HER2 in the eye and the potential for on-target side effects with antibody-drug conjugates.
Davenport S, Xie B, Hamblett K, Hausman D, Villalobos I, Singh HP, Cobrinik D, Hoon DSB, Zhou JY, Sibug-Saber M, Ma Y, Konecny GE, Heur M, Slamon DJ, Press MF. Davenport S, et al. Sci Rep. 2026 May 7. doi: 10.1038/s41598-026-51353-w. Online ahead of print. Sci Rep. 2026. PMID: 42098228 Free article.
Using immunohistochemistry, HER2 expression was identified in the human corneal, limbal and conjunctival epithelium of fetal and adult human eyes. We also identified HER2 expression in tissues from the Macaca fascicularis (monkey) to confirm a similar distribution of HER2 …
Using immunohistochemistry, HER2 expression was identified in the human corneal, limbal and conjunctival epithelium of fetal and adul …
Placental histology and vascular architecture in spontaneous twin anemia polycythemia sequence.
van de Sande MJA, Tollenaar LSA, Haak MC, Slaghekke F, Lopriore E, van der Meeren LE. van de Sande MJA, et al. Placenta. 2026 Apr 27;181:48-54. doi: 10.1016/j.placenta.2026.04.025. Online ahead of print. Placenta. 2026. PMID: 42097098 Free article.
Cases were excluded for missing pathology reports, intrauterine fetal demise, termination, intrauterine transfusion, or laser surgery. Gross and histological placental features and clinical characteristics were assessed per twin. ...Maternal vascular malperfusion occurred …
Cases were excluded for missing pathology reports, intrauterine fetal demise, termination, intrauterine transfusion, or laser surgery …
Granulicatella adiacens infective endocarditis in pregnancy: diagnostic contribution of metagenomic sequencing-a case report.
Vasselin A, Scavazzin V, Talarmin JP, Lamoureux C, Pérès M, Le Bars H, Fangous MS, Beauruelle C, Ansart S, Héry-Arnaud G. Vasselin A, et al. ASM Case Rep. 2026 Feb 24;2(3):e00237-25. doi: 10.1128/asmcr.00237-25. eCollection 2026 May. ASM Case Rep. 2026. PMID: 42094994 Free PMC article.
Infective endocarditis during pregnancy is uncommon but carries substantial maternal and fetal risk. Plasma metagenomic analysis of microbial cell-free DNA has emerged as a complementary diagnostic tool in culture-negative infections. ...
Infective endocarditis during pregnancy is uncommon but carries substantial maternal and fetal risk. Plasma metagenomic analysis of m …
Infectious causes of pregnancy loss in cattle: a review of loss intensity and major reproductive pathogens involved.
de Morais R, Borges GM, Miranda MDS, Pfeifer LFM, Viana RB, Monteiro BM. de Morais R, et al. Anim Reprod. 2026 Apr 20;23(2):e20250064. doi: 10.1590/1984-3143-AR2025-0064. eCollection 2026. Anim Reprod. 2026. PMID: 42094298 Free PMC article. Review.
Pregnancy losses represent one of the main economic problems in cattle farming, where up to half of these losses can be associated with infectious diseases. Early identification of risk factors is essential to prevent reproductive and improve productivity in both beef and …
Pregnancy losses represent one of the main economic problems in cattle farming, where up to half of these losses can be associated with infe …
Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting.
Lin X, Lee CH, Zhang T, Antanaviciute A, Hanley T, Glickman JN, Bharadwaj NS, Rosen V, Gumperz JE, Waldor MK, Simmons A, Gensollen T, Blumberg RS. Lin X, et al. Nat Commun. 2026 May 6. doi: 10.1038/s41467-026-72734-9. Online ahead of print. Nat Commun. 2026. PMID: 42091861 Free article.
Importantly, similar stromal cells are present in fetal and neonatal human colon, and human rBMP2 promotes iNKT cell growth. Together, our findings reveal a neonatal colonic stromal niche, orchestrated by microbial cues, that regulates colonic immune homeostasis in later-l …
Importantly, similar stromal cells are present in fetal and neonatal human colon, and human rBMP2 promotes iNKT cell growth. Together …
Blue light-emitting diode phototherapy reduces cerebral parasitic load and inflammation in murine congenital toxoplasmosis model.
Toledo DNM, Carlos N, Dantas-Vieira GC, Burle MMC, Duarte-Junior LA, Cruz Castro ML, Dos Santos TR, Costa GP, de Azevedo CS, Costa DC, Rabelo ÉML, Bianchi RF, Martins-Duarte ÉS, Talvani A. Toledo DNM, et al. Immunobiology. 2026 May 2;231(3):153182. doi: 10.1016/j.imbio.2026.153182. Online ahead of print. Immunobiology. 2026. PMID: 42090933 Free article.
The search for effective therapies to eradicate Toxoplasma gondii, the causative agent of toxoplasmosis, has spanned decades with limited success. ...BLP reduced parasitic load in brain tissue and modulated tissue-specific immune responses, with increased IL-10 in the brai …
The search for effective therapies to eradicate Toxoplasma gondii, the causative agent of toxoplasmosis, has spanned decades with lim …
Digital Health-Based Peer Support Ecosystem for Gestational Diabetes Mellitus in Vietnam (VALID II Study): Multistakeholder Cocreation and Pilot Study.
Dang NAT, Meyrowitsch DW, Linde DS, Vinter CA, Nguyen TD, Nguyen DK, Nguyen TA, Le HM, Vu TKD, Tran TH, Gammeltoft TM, Søndergaard J. Dang NAT, et al. J Med Internet Res. 2026 May 6;28:e82434. doi: 10.2196/82434. J Med Internet Res. 2026. PMID: 42090309 Free PMC article.
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with fetal overgrowth, increased risks of perinatal morbidity and mortality, and long-term complications for mother and child, including cardiovascular disease and type 2 diabetes. ...
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with fetal overgrowth, increased risks of perinatal morbidity and morta …
Unexpected Fetal Supraventricular Tachycardia Temporally Associated With Maternal Antihistamine Use: A Case Report.
Kermani KR, Rajaei S, Goudarzi RM, Abdi N. Kermani KR, et al. Case Rep Obstet Gynecol. 2026 May 4;2026:6498180. doi: 10.1155/crog/6498180. eCollection 2026. Case Rep Obstet Gynecol. 2026. PMID: 42088897 Free PMC article.
Fetal supraventricular tachycardia (SVT) represents the most common cause of sustained fetal tachyarrhythmia and may result in significant hemodynamic compromise when persistent. ...Owing to the persistence of the tachyarrhythmia during hospitalization, transplacent …
Fetal supraventricular tachycardia (SVT) represents the most common cause of sustained fetal tachyarrhythmia and may result in …
Pharmacometric modeling of opioid disposition in pregnancy: a systematic review of PopPK and PBPK approaches, model limitations, and future directions.
Zaidi SS, Abbasi MY, Ganapaneni S, Quinney SK. Zaidi SS, et al. Front Pharmacol. 2026 Apr 20;17:1789714. doi: 10.3389/fphar.2026.1789714. eCollection 2026. Front Pharmacol. 2026. PMID: 42088578 Free PMC article. Review.
PBPK models showed substantial heterogeneity in physiological detail, ranging from simplified fetoplacental compartments to permeability-limited placenta representations and multi-compartment fetal systems. Reproducibility emerged as a concern, with at least one PBPK model …
PBPK models showed substantial heterogeneity in physiological detail, ranging from simplified fetoplacental compartments to permeability-lim …
The Role of Exosomes in Offspring Metabolic Programming in Gestational Diabetes: Mechanisms and Potential Applications.
Zhou J, Wang D, Yu M, Zhai X, Song Y, Liu J, Xiao X. Zhou J, et al. Int J Biol Sci. 2026 Mar 30;22(8):4116-4135. doi: 10.7150/ijbs.131080. eCollection 2026. Int J Biol Sci. 2026. PMID: 42088428 Free PMC article. Review.
Exosomes have recently been identified as key mediators of maternal-fetal communication. In GDM, both the quantity and cargo (e.g., proteins, miRNAs) of exosomes are altered. ...In this review, we summarize the characteristic changes of maternal exosomes in GDM and explore …
Exosomes have recently been identified as key mediators of maternal-fetal communication. In GDM, both the quantity and cargo (e.g., p …
Steroid hormones in early pregnancy and adverse birth outcomes: a Chinese birth cohort.
Wu W, Ji C, Li H, Diao F, Wu L, Ruan X, Luo Y, Luo M. Wu W, et al. Front Endocrinol (Lausanne). 2026 Apr 20;17:1667039. doi: 10.3389/fendo.2026.1667039. eCollection 2026. Front Endocrinol (Lausanne). 2026. PMID: 42087872 Free PMC article.
While maternal steroid hormones are essential for fetal development, their individual and combined effects on ABO remain unclear. METHODS: This prospective cohort study included 364 pregnant women (30.7 4.0 years) in Guangzhou, China. ...CONCLUSIONS: Maternal hormonal mi …
While maternal steroid hormones are essential for fetal development, their individual and combined effects on ABO remain unclear. MET …
Epigenetic Perspectives on Maternal Gut Microbiota's Impact on Embryonic and Fetal Development.
Xu S, Huang Y, Hu C, Ding W, Pu Z, Li Q, Xu Z. Xu S, et al. Compr Physiol. 2026 Jun;16(3):e70163. doi: 10.1002/cph4.70163. Compr Physiol. 2026. PMID: 42087484 Free PMC article. Review.
Exposure to harmful environments during pregnancy and maternal nutritional status are key factors that affect offspring development; however, the underlying mechanisms of maternal-fetal interaction remain to be elucidated. In recent years, research on gut microbiota and ep …
Exposure to harmful environments during pregnancy and maternal nutritional status are key factors that affect offspring development; however …
Charting spatial ligand-target activity using Renoir.
Rao N, Kumar T, Kazemi D, Hou S, Khakpoor A, Eapen MM, Pai R, Qiao L, Mishra A, Ginhoux F, Chan JKY, George J, Sharma A, Zafar H. Rao N, et al. Nat Commun. 2026 May 5;17(1):3983. doi: 10.1038/s41467-026-72388-7. Nat Commun. 2026. PMID: 42086556 Free PMC article.
Across spatial datasets with varying resolution (spot to single-cell) ranging from development to disease, Renoir infers cellular niches with distinct ligand-target interactions, spatially maps pathway activities, and identifies context-specific cell-cell interactions, including …
Across spatial datasets with varying resolution (spot to single-cell) ranging from development to disease, Renoir infers cellular niches wit …
Laparoscopic cholecystectomy during pregnancy: A five-year single-centre experience.
Shah MA, Wagay BA, Aijaz SM. Shah MA, et al. J Minim Access Surg. 2026 Apr 27. doi: 10.4103/jmas.jmas_437_25. Online ahead of print. J Minim Access Surg. 2026. PMID: 42085018 Free article.
To evaluate perioperative outcomes, operative feasibility and maternal-fetal safety in pregnant patients undergoing LC in a tertiary care centre. PATIENTS AND METHODS: A hybrid retrospective-prospective observational study was conducted, including pregnant patients who und …
To evaluate perioperative outcomes, operative feasibility and maternal-fetal safety in pregnant patients undergoing LC in a tertiary …
Clinical Outcomes of Fetal Ventriculomegaly: A Retrospective Analysis from a Tertiary Referral Center.
Guo D, He S, Lin N, Dai Y, Li Y, Xu L, Wu X. Guo D, et al. Int J Womens Health. 2026 Apr 29;18:576118. doi: 10.2147/IJWH.S576118. eCollection 2026. Int J Womens Health. 2026. PMID: 42083567 Free PMC article.
OBJECTIVE: To evaluate perinatal outcomes in fetal ventriculomegaly (VM). METHODS: We retrospectively reviewed 720 pregnancies diagnosed with fetal ventriculomegaly (VM) between 2014 and 2018. ...
OBJECTIVE: To evaluate perinatal outcomes in fetal ventriculomegaly (VM). METHODS: We retrospectively reviewed 720 pregnancies diagno …
Compound heterozygous mutations in CC2D2A cause Meckel-Gruber syndrome: a case report and review of the literature.
Liu L, Lv Y, Zhou X. Liu L, et al. J Med Case Rep. 2026 May 4. doi: 10.1186/s13256-026-06070-3. Online ahead of print. J Med Case Rep. 2026. PMID: 42083041 Free article.
CASE PRESENTATION: A 30-year-old Chinese primigravida (G1P0) from Shandong Province was referred at 23 week gestation following prenatal ultrasound detection of fetal anomalies. Key findings included bilateral enlarged hyperechoic kidneys (renal transverse diameter: 35 mm, …
CASE PRESENTATION: A 30-year-old Chinese primigravida (G1P0) from Shandong Province was referred at 23 week gestation following prenatal ult …
The therapeutic potential of zinc-nanoparticles against the cerebellar neurotoxicity induced by bacterial lipopolysaccharides in female rats and their pups.
El-Beltagy AEBM, Eladad M, Kamel K, Elsayyad HIH, Attallah A. El-Beltagy AEBM, et al. Sci Rep. 2026 May 4;16(1):14629. doi: 10.1038/s41598-026-50012-4. Sci Rep. 2026. PMID: 42082605 Free PMC article.
LPS correlates with unfavorable developmental consequences, such as preterm birth, fetal demise, teratogenic effects, and intrauterine growth restriction. Zinc is essential for embryogenesis, fetal development, and lactation. ...
LPS correlates with unfavorable developmental consequences, such as preterm birth, fetal demise, teratogenic effects, and intrauterin …
Reversible Neurological Manifestations Preceding Biochemical Deterioration in Postpartum HELLP Syndrome-A Case Report and Literature Review.
Colacurci D, Giannubilo SR, Sarno L, Fulgione C, Mazzarelli LL, Sirico A, Meccariello ML, Albanese A, Quintili D, Lubinski I, Ascione M, Riccardi C, D'Apice G, Motta M, Iannantuoni S, Murolo C, Bifulco G, Di Carlo C, Ciavattini A, Maruotti GM. Colacurci D, et al. J Clin Hypertens (Greenwich). 2026 May;28(5):e70267. doi: 10.1111/jch.70267. J Clin Hypertens (Greenwich). 2026. PMID: 42082345 Free PMC article. Review.
A 22-year-old primigravida was admitted at 36 + 0 weeks for premature rupture of membranes and fetal growth restriction, presenting with mild thrombocytopenia and elevated lactate dehydrogenase but normal liver enzymes. ...The patient was treated with magnesium sulfate, an …
A 22-year-old primigravida was admitted at 36 + 0 weeks for premature rupture of membranes and fetal growth restriction, presenting w …
On the potential origin of the zygote-like cancer stem cell with a focus on fusion for cell rescue.
Cismaru CA, Chira S, Calin GA, Netea-Maier R, Berindan-Neagoe I. Cismaru CA, et al. Front Cell Dev Biol. 2026 Apr 17;14:1797239. doi: 10.3389/fcell.2026.1797239. eCollection 2026. Front Cell Dev Biol. 2026. PMID: 42080089 Free PMC article.
We review experimental evidence for the reactivation of embryonic genes, emergence of cancer stem cells, and therapy resistance by the developmental programme hijack via cell fusion. Furthermore, based on our previous findings on fetal-maternal microchimerism, in th …
We review experimental evidence for the reactivation of embryonic genes, emergence of cancer stem cells, and therapy resistance by th …
Broad ligament defect internal hernia: a rare cause of bowel obstruction in pregnancy.
AlQusaibi BK, Bamalan OA, Danawar NA, Zaki WA. AlQusaibi BK, et al. J Surg Case Rep. 2026 Apr 30;2026(4):rjag335. doi: 10.1093/jscr/rjag335. eCollection 2026 Apr. J Surg Case Rep. 2026. PMID: 42078161 Free PMC article.
The persistence of clinical deterioration despite conservative therapy should prompt urgent surgical evaluation, and when indicated, laparoscopy is considered safe in pregnancy and provides diagnostic and definitive management. This case emphasizes that signs of SBO should …
The persistence of clinical deterioration despite conservative therapy should prompt urgent surgical evaluation, and when indicated, …
Multiplexed Isothermal Amplification Assay for the Detection of Plasmodium falciparum and Trichomonas vaginalis in Urine.
Dupaty J, Shiluli C, Schaus B, Lolabattu SR, Gitaka J, Klapperich C. Dupaty J, et al. ACS Omega. 2026 Apr 13;11(16):24086-24096. doi: 10.1021/acsomega.5c12022. eCollection 2026 Apr 28. ACS Omega. 2026. PMID: 42077865 Free PMC article.
Meanwhile, T. vaginalis, the most prevalent nonviral sexually transmitted infection, exacerbates poor maternal and fetal outcomes when co-infections occur. In this study, we present a multiplexed isothermal nucleic acid amplification assay (iso-IMRS) for simultaneous detec …
Meanwhile, T. vaginalis, the most prevalent nonviral sexually transmitted infection, exacerbates poor maternal and fetal outcomes whe …
The Role of Immunological Bystander Reaction in Recurrent Pregnancy Loss.
Lakhno I. Lakhno I. Cureus. 2026 Mar 31;18(3):e106246. doi: 10.7759/cureus.106246. eCollection 2026 Mar. Cureus. 2026. PMID: 42077679 Free PMC article. Review.
These reactions occur when the maternal immune system's response to a specific target extends to nearby tissues, causing collateral damage to both maternal and fetal cells. This narrative review explores the mechanisms of immune dysregulation at the maternal-fetal i …
These reactions occur when the maternal immune system's response to a specific target extends to nearby tissues, causing collateral damage t …
Mechanism of FoxO1 in the Metabolic Shift of Fetal Rat Heart.
William W, Kartinah NT, Prijanti AR, Yuniadi Y, Yusuf PA, Lim YP. William W, et al. Molecules. 2026 Apr 13;31(8):1275. doi: 10.3390/molecules31081275. Molecules. 2026. PMID: 42075954 Free PMC article.
Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide, underscoring the need to better understand cardiovascular physiology. ...This study investigated FoxO1 in metabolic adaptation using Wistar rats divided into age groups (fetal, post …
Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide, underscoring the need to better understand cardi …
Histopathologic Reassessment of Placental Vascular Lesions Based on the Amsterdam Consensus Criteria: A Retrospective Analysis of 571 Placental Cases.
Altunay Ünal B, Çobankent Aytekin E, Toru HS. Altunay Ünal B, et al. Medicina (Kaunas). 2026 Apr 16;62(4):773. doi: 10.3390/medicina62040773. Medicina (Kaunas). 2026. PMID: 42075645 Free PMC article.
Hematoxylin-eosin-stained sections from all cases were re-evaluated, and maternal vascular malperfusion (MVM), fetal vascular malperfusion (FVM), and other placental vascular pathologies were assessed according to the Amsterdam consensus criteria. ...
Hematoxylin-eosin-stained sections from all cases were re-evaluated, and maternal vascular malperfusion (MVM), fetal vascular malperf …
Visceral Artery Aneurysms in Pregnancy and Women of Childbearing Age: A Primary and Emergency Care Approach.
Kilby J, Hon K, Kocak ED, Hidajat C, Tran A, Gordon J, Gan C. Kilby J, et al. Medicina (Kaunas). 2026 Apr 9;62(4):716. doi: 10.3390/medicina62040716. Medicina (Kaunas). 2026. PMID: 42075588 Free PMC article. Review.
Computed tomography angiography (CTA) remains the gold standard for diagnosis and is safe in pregnancy when clinically justified, with fetal radiation exposure well below teratogenic thresholds. Guidelines from major vascular societies uniformly recommend repairing VAAs in …
Computed tomography angiography (CTA) remains the gold standard for diagnosis and is safe in pregnancy when clinically justified, with fe …
Pregnancy Associated Melanoma: Diagnostic and Therapeutic Challenges.
Atanasescu VP, Atanasescu IE, Mehedintu C, Ristea MR, Alexandru AN, Dogaru IM, Boga BM, Oproiu AM. Atanasescu VP, et al. Medicina (Kaunas). 2026 Mar 27;62(4):642. doi: 10.3390/medicina62040642. Medicina (Kaunas). 2026. PMID: 42075514 Free PMC article. Review.
In select patients, a sentinel lymph node biopsy may also be performed. Due to the risk of fetal harm, systemic therapy (targeted agents and/or immune checkpoint inhibitors) cannot be used for the treatment of PAM during pregnancy. ...
In select patients, a sentinel lymph node biopsy may also be performed. Due to the risk of fetal harm, systemic therapy (targe …
Beyond 25(OH)D: Carboxylated Osteocalcin and the Undercarboxylated/Carboxylated Osteocalcin Ratio as Superior Biomarkers for Vitamin D Recovery in Offspring Affected by Maternal Deficiency.
Chan WT, Lee HC, Yeung CY, Chiang Chiau JS, Cheng ML, Chang SW, Weng SC, Jiang CB. Chan WT, et al. Nutrients. 2026 Apr 15;18(8):1243. doi: 10.3390/nu18081243. Nutrients. 2026. PMID: 42075056 Free PMC article.
Background: Maternal vitamin D deficiency (VDD) compromises fetal skeletal development. The impact of postnatal vitamin D supplementation on osteocalcin (OC) carboxylation, converting undercarboxylated (ucOC) to carboxylated osteocalcin (cOC), in offspring remains unclear, …
Background: Maternal vitamin D deficiency (VDD) compromises fetal skeletal development. The impact of postnatal vitamin D supplementa …
Prenatal Fine Particulate Matter (PM2.5) Exposure and the Riskof Pediatric Inguinal Hernia or Hydrocele: A RetrospectiveCohort Study.
Kim EJ, Bae JG, Koo EJ. Kim EJ, et al. J Clin Med. 2026 Apr 17;15(8):3089. doi: 10.3390/jcm15083089. J Clin Med. 2026. PMID: 42074891 Free PMC article.
Background/Objectives: Inguinal hernia and hydrocele are common pediatric surgical conditions resulting from failed obliteration of the processus vaginalis during fetal development. Although prenatal exposure to fine particulate matter (PM2.5) has been linked to adverse pe …
Background/Objectives: Inguinal hernia and hydrocele are common pediatric surgical conditions resulting from failed obliteration of the proc …
A Cross-Species Single-Cell Atlas Reveals Conserved Regulatory Networks and Candidate Hearing Loss Genes in the Cochlea.
Cheng H, Ai F, Hua W, Bu F. Cheng H, et al. Genes (Basel). 2026 Apr 10;17(4):438. doi: 10.3390/genes17040438. Genes (Basel). 2026. PMID: 42074555 Free PMC article.
To elucidate its cellular and molecular architecture and prioritize candidate genes associated with hearing loss (HL), we constructed a cross-species single-cell transcriptomic atlas of human fetal and postnatal mouse cochleae. Methods: We integrated single-cell and single …
To elucidate its cellular and molecular architecture and prioritize candidate genes associated with hearing loss (HL), we constructed a cros …
Morphological Features and HIF1-Dependent Processes in the Brain of Progeny of Female Rats Exposed to Maternal Hypoxia.
Potapova S, Zugan E, Isakov Y, Tyulkova E, Vetrovoy O. Potapova S, et al. Int J Mol Sci. 2026 Apr 10;27(8):3421. doi: 10.3390/ijms27083421. Int J Mol Sci. 2026. PMID: 42074064 Free PMC article.
Fetal hypoxia and maternal stress during pregnancy are major risk factors for neurological disorders. ...In this study, using immunohistochemistry, quantitative RT-PCR, and Western blotting, we assessed morphological features and HIF1-dependent processes in the fetal …
Fetal hypoxia and maternal stress during pregnancy are major risk factors for neurological disorders. ...In this study, using immunoh …
Amino Acid Dysregulation in the Mother-Fetus Unit: Multi-Compartment Metabolomic Signatures of Gestational Diabetes Mellitus and Fetal Macrosomia.
Frankevich NA, Tokareva AO, Derenko AA, Chagovets VV, Novoselova AV, Frankevich VE, Sukhikh GT. Frankevich NA, et al. Int J Mol Sci. 2026 Apr 8;27(8):3346. doi: 10.3390/ijms27083346. Int J Mol Sci. 2026. PMID: 42073989 Free PMC article.
The role of amino acid disturbances in the mother-fetus system remains poorly understood, despite their critical involvement in gestational diabetes mellitus (GDM), fetal macrosomia (FM) and offspring metabolic programming. This study included 62 mother-newborn dyads strat …
The role of amino acid disturbances in the mother-fetus system remains poorly understood, despite their critical involvement in gestational …
Sleep Disruption, Psychological Stress, and Preeclampsia in High-Risk Pregnancies During the COVID-19 Era.
Kundnani NR, Sharma A, Cornea A, Buciu VB, Brandibur T, Hogea L, Mladin NC, Mogos GFR. Kundnani NR, et al. Life (Basel). 2026 Apr 5;16(4):605. doi: 10.3390/life16040605. Life (Basel). 2026. PMID: 42073415 Free PMC article.
CONCLUSIONS: In high-risk pregnancies, integrated evaluation of sleep and stress parameters may improve the prediction of fetal growth impairment and preeclampsia beyond single-domain models. These findings support the incorporation of psychosocial and behavioral markers i …
CONCLUSIONS: In high-risk pregnancies, integrated evaluation of sleep and stress parameters may improve the prediction of fetal growt …
Impact of Maternal Valaciclovir Therapy on Early Neurodevelopment in Congenital CMV Infection: A Retrospective Pilot Study.
Arcieri F, Vasta A, Volpe G, Natale F, Caravale B, Di Mascio D, D'Ambrosio V, De Cicco M, Terrin G, Oliva L, Prestianni C, Liuzzi G, Manganaro L, Giancotti A. Arcieri F, et al. Children (Basel). 2026 Apr 18;13(4):566. doi: 10.3390/children13040566. Children (Basel). 2026. PMID: 42073143 Free PMC article.
Background/Objectives: Maternal valaciclovir therapy is increasingly used to reduce fetal viral replication in cases of primary cytomegalovirus (CMV) infection during pregnancy. ...
Background/Objectives: Maternal valaciclovir therapy is increasingly used to reduce fetal viral replication in cases of primar …
Impact of Telehealth and Social Drivers of Health on Utilization of Fetal Center Services.
Khanna NM, Kadakia S, Diep QM, Bowker RM. Khanna NM, et al. Children (Basel). 2026 Apr 13;13(4):538. doi: 10.3390/children13040538. Children (Basel). 2026. PMID: 42073118 Free PMC article.
Background: Data is limited regarding the impact of social drivers of health (SDOH) on fetal center (FNMC) service utilization. Objectives: The objectives of this study were to (1) compare FNMC utilization by era (pre-telehealth era vs. ...Results: Race/ethnicity was assoc …
Background: Data is limited regarding the impact of social drivers of health (SDOH) on fetal center (FNMC) service utilization. Objec …
Maternal Corporeal Support in Terminal Stage Brain Astrocytoma: A Case Report and Literature Review.
Sertaridou EN, Tsouvala E, Papaioannou VE, Alexopoulou C. Sertaridou EN, et al. Healthcare (Basel). 2026 Apr 15;14(8):1055. doi: 10.3390/healthcare14081055. Healthcare (Basel). 2026. PMID: 42072955 Free PMC article.
Aim: The presentation of a pregnant woman with a terminal stage brain astrocytoma, admitted in the intensive care unit (ICU) to support the pregnancy, until optimal fetal viability, after she had neurological deterioration and confirmed BD, and a brief literature review of …
Aim: The presentation of a pregnant woman with a terminal stage brain astrocytoma, admitted in the intensive care unit (ICU) to support the …
Maternal-Fetal Implications of Herpes Virus Infection: An Updated Review.
Silva Pereira S, Bussi Rosolen B, Almeida Durães T, Fermoselle de Vita Silva M, Alves de Britto G, Silva Belo C, Cristina Campos T, Callado GY, Cristina Aidé Viviani Fialho S, Braga A, Araujo Júnior E. Silva Pereira S, et al. Diagnostics (Basel). 2026 Apr 13;16(8):1147. doi: 10.3390/diagnostics16081147. Diagnostics (Basel). 2026. PMID: 42072773 Free PMC article. Review.
Acyclovir and valacyclovir are safe and effective in pregnancy. Suppressive therapy from 36 weeks' gestation reduces recurrences and viral shedding at delivery and decreases the need for cesarean delivery, which is recommended when active lesions or prodromal symptoms are …
Acyclovir and valacyclovir are safe and effective in pregnancy. Suppressive therapy from 36 weeks' gestation reduces recurrences and …
Cervicofacial Actinomycosis Presenting as a Fistulized Neck Mass During Pregnancy: A Case Report.
Severin F, Andoni AA, Serban RI, Nicolau A, Mereuta DV, Vlad A, Mocanu F, Roman IA, Palade OD. Severin F, et al. Diagnostics (Basel). 2026 Apr 10;16(8):1140. doi: 10.3390/diagnostics16081140. Diagnostics (Basel). 2026. PMID: 42072766 Free PMC article.
Considering the pregnancy, drainage of the collection was performed under local anesthesia and empiric antibiotic therapy with amoxicilin-clavulanic acid was started. Microbiological confirmation of Actinomyces (Schaalia) georgiae led to infectious disease evaluation that …
Considering the pregnancy, drainage of the collection was performed under local anesthesia and empiric antibiotic therapy with amoxic …
Pregnancy and Peripartum Multidisciplinary Management in Wolfram Syndrome Type 1: A Case Report.
Esteban-Bueno G, Serrano Rodríguez ML. Esteban-Bueno G, et al. Diagnostics (Basel). 2026 Apr 8;16(8):1117. doi: 10.3390/diagnostics16081117. Diagnostics (Basel). 2026. PMID: 42072744 Free PMC article.
Postpartum recovery was favorable, although anemia on postoperative day 1 required transfusion of one unit of packed red blood cells and intravenous iron therapy. Discussion and Conclusions: Pregnancy in WS1 represents a high-risk clinical scenario because of the coexisten …
Postpartum recovery was favorable, although anemia on postoperative day 1 required transfusion of one unit of packed red blood cells and int …
Life-Course Regulation of Health and Disease by Nitric Oxide: Mechanistic Insights.
Hsu CN, Tain YL. Hsu CN, et al. Antioxidants (Basel). 2026 Apr 1;15(4):439. doi: 10.3390/antiox15040439. Antioxidants (Basel). 2026. PMID: 42072081 Free PMC article. Review.
This narrative review examines NO signaling from a life-course perspective, beginning with fetal programming, during which the NO-asymmetric dimethylarginine (ADMA) axis orchestrates placental development and nephron endowment. ...Integrating such early-life strategies wit …
This narrative review examines NO signaling from a life-course perspective, beginning with fetal programming, during which the NO-asy …
Spinal muscular atrophy type I in a 3.5-month-old male infant: A case report.
Nawaz RN, Asjad W, Bashir R, Saeed SAA, Tayyab MZ, Khalid M. Nawaz RN, et al. Medicine (Baltimore). 2026 Apr 24;105(17):e48512. doi: 10.1097/MD.0000000000048512. Medicine (Baltimore). 2026. PMID: 42071833 Free PMC article.
DIAGNOSES: Antenatal history revealed polyhydramnios and reduced fetal movements in the third trimester. Electromyography revealed severe motor neuropathy in lower limbs, and multiplex ligation-dependent probe amplification analysis confirmed homozygous deletion of the sur …
DIAGNOSES: Antenatal history revealed polyhydramnios and reduced fetal movements in the third trimester. Electromyography revealed se …
Cell-free DNA fragmentomics for preeclampsia risk assessment.
Xu W, Chen S, Li J, Zhou S, Yin Y, Qiu Z, Zhang J, Liu C, Zhao Q, Xiao G, Zhou Y, Zhao Z, Zhang X, Yang W, Wang Y, Li H, Yang Z, Feng S, Zhang Q, Chen W, Li H, Ruan X, Li H, Zhang S, Hu L, Qin J, Huang W, Li Z, Cao X, Zhou X, Xu N, Hou D, Dong H, Wang J, Liu Y, Zhang Q, Wang X, Zhao L, Huang H, Xu C. Xu W, et al. Nat Commun. 2026 May 2. doi: 10.1038/s41467-026-72682-4. Online ahead of print. Nat Commun. 2026. PMID: 42069757 Free article.
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet early identification of women at risk remains challenging because reliable biomarkers are limited. ...
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet earl …
Multicohort analysis unveils axon guidance pathways linking small for gestational age to spirometric restriction.
Read JF, Stern DA, Carr TF, Spangenberg AL, Yang M, Luna-Ramirez RI, Guerra S, Morgan WJ, Binder AT, VanWormer JJ, Seroogy CM, Miller RL, Zoratti EM, Ober C, Jackson DJ, Limesand SW, Gold DR, Gern JE; CADRE consortium; Bosco A, Martinez FD. Read JF, et al. Nat Commun. 2026 May 2. doi: 10.1038/s41467-026-72490-w. Online ahead of print. Nat Commun. 2026. PMID: 42069698 Free article.
Using GWAS data and an experimental sheep model, we obtain convergent evidence that axon-guidance genes are associated with spirometric indices (FEV(1)/FVC) at genome-wide significance and are broadly expressed during fetal development across multiple organs. These finding …
Using GWAS data and an experimental sheep model, we obtain convergent evidence that axon-guidance genes are associated with spirometric indi …
Complex inguinal herniation containing a gravid uterus in a bitch - successful surgery and neonatal survival: a case report.
Matyaszczyk M, Sowińska N, Piątek M, Kotwica S. Matyaszczyk M, et al. BMC Vet Res. 2026 May 1. doi: 10.1186/s12917-026-05527-3. Online ahead of print. BMC Vet Res. 2026. PMID: 42067933 Free article.
Only a few cases have been documented, and most were diagnosed in early gestation or following complications such as fetal death. To our knowledge, reports of IGH diagnosed close to term and successfully managed surgically, resulting in live offspring, are limited. ...Phys …
Only a few cases have been documented, and most were diagnosed in early gestation or following complications such as fetal death. To …
Reduced type 2 epithelial-mesenchymal transition serves as a risk factor for the progression from endometriosis to endometriosis-associated ovarian cancer.
Liu Y, Yin D, Wu L, Wang H, Song Y, Huang J, Zhou J, Li H, Liang P, He H. Liu Y, et al. Sci Rep. 2026 May 1. doi: 10.1038/s41598-026-51155-0. Online ahead of print. Sci Rep. 2026. PMID: 42067629 Free article.
Epithelial-mesenchymal transition (EMT) plays a crucial role in the progression of various diseases, but the specific EMT changes in EAOC formation remain unclear. We retrieved transcriptomic data for EAOC and single-cell data for EMS from public databases and systematical …
Epithelial-mesenchymal transition (EMT) plays a crucial role in the progression of various diseases, but the specific EMT changes in …
Meteorological, ozone, maternal and individual-level risk factors for childhood diseases in Singapore: A prospective birth cohort study from 2009 to 2019.
Aik J, Lau HX, Woo M, Shek LP, Lee BW, Goh AEN, Tan KH, Yap FKP, Gluckman P, Chong YS, Eriksson JG, Loo EXL. Aik J, et al. Ecotoxicol Environ Saf. 2026 Jun 1;317:120189. doi: 10.1016/j.ecoenv.2026.120189. Epub 2026 Apr 30. Ecotoxicol Environ Saf. 2026. PMID: 42066443 Free article.
Few studies have examined the effects of these phenomena on childhood respiratory and allergic diseases in tropical countries, hence we aim to bridge this research gap. METHODS: We ascertained the first occurrence of eczema, wheeze and bronchiolitis in 1124 mother-child pa …
Few studies have examined the effects of these phenomena on childhood respiratory and allergic diseases in tropical countries, hence …
High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4+ T cells during third-trimester pregnancy.
Habel JR, Nguyen THO, de Alwis N, Allen EK, Li S, Skinner MJ, Juno JA, Kent SJ, Bond K, Williamson DA, Lappas M, Hannan NJ, Walker S, Schroeder J, Crawford JC, Thomas PG, Kedzierska K, Rowntree LC. Habel JR, et al. Clin Transl Immunology. 2026 Apr 28;15:e70096. doi: 10.1002/cti2.70096. eCollection 2026. Clin Transl Immunology. 2026. PMID: 42065097 Free PMC article.
This provides important mechanistic insight of their adaptation and regulation during placental development, which may drive placental dysfunction or pregnancy complications, including preeclampsia, fetal growth restriction and stillbirth. These new data may inform future …
This provides important mechanistic insight of their adaptation and regulation during placental development, which may drive placental dysfu …
Upregulation of Sox2 Following Saracatinib Treatment Contributes to a Resistant Phenotype in Colorectal Cancer Cells under Growth Factor-Supplemented Conditions.
Yoon C, Na E, Choi MJ, Yoon SP. Yoon C, et al. Oncol Res. 2026 Apr 22;34(5):23. doi: 10.32604/or.2026.074140. eCollection 2026. Oncol Res. 2026. PMID: 42065072 Free PMC article.
METHODS: Wild-type and 5-fluorouracil-resistance acquired SNU-C5 colorectal cancer cells were cultured in both monolayer and spheroid systems under fetal bovine serum (FBS) or growth factor (GF) supplemented conditions. Cell viability assay, flow cytometry, wound healing a …
METHODS: Wild-type and 5-fluorouracil-resistance acquired SNU-C5 colorectal cancer cells were cultured in both monolayer and spheroid system …
Production, pricing, and incentives in the fetal bovine serum market.
Jungbluth AN, Brorsen BW, Peel DS. Jungbluth AN, et al. Transl Anim Sci. 2026 Apr 10;10:txag044. doi: 10.1093/tas/txag044. eCollection 2026. Transl Anim Sci. 2026. PMID: 42064877 Free PMC article.
Fetal bovine serum (FBS) is a valuable byproduct of cattle production, critical for vaccines, cell therapy, and other cell growth applications. ...
Fetal bovine serum (FBS) is a valuable byproduct of cattle production, critical for vaccines, cell therapy, and other cell gro …
Heartbeat: a multimodal dataset of fetal echocardiography and clinical metadata for early detection of congenital heart disease.
Rodríguez S, Pérez A, Echeverry LM, Castillo Á, Ramírez NA, Escobar M, Guarín Monroy S, Vega D, Rodríguez N, Castro-Páez C, Navarro J, Domínguez MT, Laverde N, Sarmiento LA, Afanador D, D'silva Londoño L, Torres Narváez E, Fandiño MJ, Madrid AJ, Quintero JC, Rodríguez N, Briceño JC, Arbeláez P. Rodríguez S, et al. Front Cardiovasc Med. 2026 Apr 15;13:1726484. doi: 10.3389/fcvm.2026.1726484. eCollection 2026. Front Cardiovasc Med. 2026. PMID: 42064861 Free PMC article.
BACKGROUND: Congenital heart diseases (CHDs) remain the leading cause of infant mortality attributable to birth defects. ...METHODS: This study introduces Heartbeat, a multicenter, anonymized multimodal dataset comprising fetal cardiac ultrasound images and associat …
BACKGROUND: Congenital heart diseases (CHDs) remain the leading cause of infant mortality attributable to birth defects. ...METHODS: …
Antenatal management of HNF4A-MODY and INSR mutations in pregnancy.
Wu K, Russell H, Rodrigo N. Wu K, et al. JCEM Case Rep. 2026 Apr 29;4(6):luag090. doi: 10.1210/jcemcr/luag090. eCollection 2026 Jun. JCEM Case Rep. 2026. PMID: 42064724 Free PMC article.
Molecular testing confirmed pathogenic variants in HNF4A and INSR. Noninvasive prenatal testing predicted fetal inheritance of the HNF4A variant. Despite good maternal glycemic control and relatively low insulin requirements, the infant was macrosomic and developed persist …
Molecular testing confirmed pathogenic variants in HNF4A and INSR. Noninvasive prenatal testing predicted fetal inheritance of the HN …
Placental biology links genetic, epigenetic, ancestral, and social determinants to maternal-fetal health inequities.
Schuch V, Mukherjee I, de Carvalho ARN, Olanrewaju R, Davis J, Thomas S, Chakraborty R, Johnson EL. Schuch V, et al. Front Reprod Health. 2026 Apr 15;8:1783837. doi: 10.3389/frph.2026.1783837. eCollection 2026. Front Reprod Health. 2026. PMID: 42064409 Free PMC article. Review.
We further describe how placental epigenetic mechanisms link socioeconomic and environmental exposures to fetal development, placental aging, and long-term maternal-child health. Finally, we discuss how pregnancy and placental datasets remain sparse and fragmented, and con …
We further describe how placental epigenetic mechanisms link socioeconomic and environmental exposures to fetal development, placenta …
Regulatory T cells in human pregnancy: mechanisms, dysregulation, and therapeutic perspectives.
Liu H, Huang W, Hu Z, Han J, Gao R, Qin L. Liu H, et al. Front Immunol. 2026 Apr 15;17:1815957. doi: 10.3389/fimmu.2026.1815957. eCollection 2026. Front Immunol. 2026. PMID: 42064042 Free PMC article. Review.
Regulatory T cells (Tregs) play a central role in maintaining immune tolerance and supporting maternal-fetal homeostasis throughout human pregnancy. Clinical and experimental evidence demonstrates that dysregulation of peripheral and decidual Tregs manifested as quantitati …
Regulatory T cells (Tregs) play a central role in maintaining immune tolerance and supporting maternal-fetal homeostasis throughout h …
Reimagining Placental Perfusion in Preeclampsia: Integrating Doppler Ultrasound, Three-dimensional Vascular Indices, and Predictive Artificial Intelligence.
Andonotopo W, Bachnas MA, Dewantiningrum J, Pramono MBA, Sanjaya INH, Darmawan E, Aldiansyah D, Stanojevic M, Kurjak A. Andonotopo W, et al. J Med Ultrasound. 2026 Mar 21;34(1):22-34. doi: 10.4103/jmu.JMU-D-25-00090. eCollection 2026 Jan-Mar. J Med Ultrasound. 2026. PMID: 42063928 Free PMC article. Review.
Preeclampsia remains a major cause of maternal and fetal morbidity worldwide, originating from abnormal placental development and reduced perfusion. ...
Preeclampsia remains a major cause of maternal and fetal morbidity worldwide, originating from abnormal placental development and red …
Immune microenvironment dynamics in pregnant patients with concomitant autoimmune diseases: mechanisms, challenges, and clinical significance.
Ma ZJ, Chen J, Yang CX, Lin SP, Gong Q, Braunstein Z, Wei YY, Rao XQ, Zhong JX. Ma ZJ, et al. Mil Med Res. 2026;13(1):100015. doi: 10.1016/j.mmr.2026.100015. Epub 2026 Apr 4. Mil Med Res. 2026. PMID: 42063459 Free PMC article. Review.
Throughout pregnancy, the immune microenvironment undergoes dynamic changes in patients with concomitant autoimmune diseases (AIDs). These alterations not only affect disease activity and clinical manifestations, but also play a pivotal role in sustaining maternal-fetal …
Throughout pregnancy, the immune microenvironment undergoes dynamic changes in patients with concomitant autoimmune diseases (AIDs). …
Sex-specific rat placental molecular responses to G protein-coupled estrogen receptor (GPER) activation.
Manoharan MM, Alencar AKN, Swan KF, Lindsey SH, Pridjian GC, Bayer CL. Manoharan MM, et al. Placenta. 2026 Apr 24;181:37-39. doi: 10.1016/j.placenta.2026.04.024. Online ahead of print. Placenta. 2026. PMID: 42061342 Free article.
Fetal sex-based differences in responses to treatments have been observed in many gestational diseases, including preeclampsia (PE). ...We compared the male and female fetal placental mRNA levels of PE biomarkers in response to GPER stimulation in reduced ute …
Fetal sex-based differences in responses to treatments have been observed in many gestational diseases, including preeclampsia …
Correction of hypoxemia and hypoglycemia restores muscle mitochondrial respiration and remodels mitochondrial proteome in growth-restricted sheep fetuses.
Zhao W, Chrisenberry DB, Varela M, Luna-Ramirez RI, Anderson MJ, Langlais PR, Brown LD, Limesand SW. Zhao W, et al. Am J Physiol Endocrinol Metab. 2026 Jun 1;330(6):E774-E781. doi: 10.1152/ajpendo.00073.2026. Epub 2026 Apr 30. Am J Physiol Endocrinol Metab. 2026. PMID: 42059806 Free article.
Placental insufficiency causes fetal hypoxemia and hypoglycemia and is a major driver of fetal growth restriction (FGR). ...Near-term fetuses were chronically catheterized and received 7-10 days of maternal tracheal oxygen insufflation and fetal intravenous ( …
Placental insufficiency causes fetal hypoxemia and hypoglycemia and is a major driver of fetal growth restriction (FGR). ...Ne …
Case Report: Delivery or not, generalized arterial calcification of infancy in China.
Guo Y, Wang J, Gu Y, Ma Q, Lin L. Guo Y, et al. Front Med (Lausanne). 2026 Apr 14;13:1761482. doi: 10.3389/fmed.2026.1761482. eCollection 2026. Front Med (Lausanne). 2026. PMID: 42058406 Free PMC article.
The majority of cases are caused by biallelic variants in the ENPP1 gene, leading to deficiency of an enzyme critical for preventing pathological calcium deposition in arterial walls. The prognosis of GACI is severe, with fetal and infant mortality rates reaching up to 55% …
The majority of cases are caused by biallelic variants in the ENPP1 gene, leading to deficiency of an enzyme critical for preventing patholo …
Associations between maternal smoking around birth and hepatocellular carcinoma: A bidirectional two-sample Mendelian randomization study in East Asian populations.
Liu W, Yu W, Zhang K, Wang M. Liu W, et al. Tob Induc Dis. 2026 Apr 28;24. doi: 10.18332/tid/218848. eCollection 2026. Tob Induc Dis. 2026. PMID: 42058183 Free PMC article.
INTRODUCTION: Maternal smoking around birth is known to cause a range of adverse fetal outcomes. This study aimed to investigate the potential relationship between maternal smoking around birth and the susceptibility of offspring to hepatocellular carcinoma (HCC) in East A …
INTRODUCTION: Maternal smoking around birth is known to cause a range of adverse fetal outcomes. This study aimed to investigate the …
A new dawn for Parkinson's disease: commentary on the emergence of stem cell-based therapies.
Elvira R, Chooi WH, Wang H, Tan EK, Zhou ZD. Elvira R, et al. Transl Neurodegener. 2026 Apr 29;15(1):20. doi: 10.1186/s40035-026-00556-2. Transl Neurodegener. 2026. PMID: 42057158 Free PMC article. Review.
Here we analyze three landmark 2025 studies, including the phase I/II trial of allogeneic induced pluripotent stem cell-derived dopaminergic progenitors, that mark a significant leap forward for PD therapy. We discuss principles underpinning the therapy, the histori …
Here we analyze three landmark 2025 studies, including the phase I/II trial of allogeneic induced pluripotent stem cell-derived dopaminergic …
Efficacy of Ayurveda Regimen as an Adjunct to Hydroxyurea in Sickle Cell Disease: Protocol for a Prospective, Randomized, Open-Label, Blinded End Point Exploratory Study.
Javed D, Rai AK, Bansal S, Yadav B, Shrivastava M, Goel G, Kumar A, Kumar S, Ahmad A, Singhal R, Sharma BS, Mangal A, Chandrasekhararao B, Srikanth N, Acharya R. Javed D, et al. JMIR Res Protoc. 2026 Apr 29;15:e79603. doi: 10.2196/79603. JMIR Res Protoc. 2026. PMID: 42054235 Free PMC article.
The primary outcome will be a change in hemoglobin electrophoresis parameters (hemoglobin S, fetal hemoglobin, and adult hemoglobin) and the frequency of VOC episodes over 8 months. ...
The primary outcome will be a change in hemoglobin electrophoresis parameters (hemoglobin S, fetal hemoglobin, and adult hemoglobin) …
Considerations for early life genetic therapies in cystic fibrosis.
Cooney AL, Thornell IM, Pezzulo AA, Fischer AJ, Cook DP, Abou Alaiwa MH, Larson Ode KM, Uc A, Zabner J, Ryan AL, Stoltz DA, Sinn PL, McCray PB Jr, Meyerholz DK. Cooney AL, et al. Am J Physiol Lung Cell Mol Physiol. 2026 Apr 29. doi: 10.1152/ajplung.00022.2026. Online ahead of print. Am J Physiol Lung Cell Mol Physiol. 2026. PMID: 42053522 Free article.
Genetic therapies have yet to be approved for clinical use in pwCF, but multiple clinical trials are in progress. ...In this multidisciplinary review, we discuss several pertinent factors such as CFTR localization and function, CF disease origins, emerging developments in …
Genetic therapies have yet to be approved for clinical use in pwCF, but multiple clinical trials are in progress. ...In this multidis …
Impact of a Routine Third Trimester Ultrasound Policy on Obstetric, Neonatal and Service Delivery Outcomes in an Australian Tertiary Centre.
Kumar P, Gordon A, Fisher E, Flores JG, Khan S, Narayan R, Vries BDE, Hyett J, Mogra R. Kumar P, et al. Aust N Z J Obstet Gynaecol. 2026 Jun;66(3):e70139. doi: 10.1111/ajo.70139. Aust N Z J Obstet Gynaecol. 2026. PMID: 42053190 Free PMC article.
MATERIALS AND METHODS: A single-centre retrospective cohort study was conducted comparing a pre-policy cohort that received ultrasound scans measuring biometry and fetal Dopplers when deemed clinically necessary during the third trimester with a post-policy cohort in which …
MATERIALS AND METHODS: A single-centre retrospective cohort study was conducted comparing a pre-policy cohort that received ultrasound scans …
Maternal-Fetal Antibiotic Dynamics in Suspected Chorioamnionitis: A Data Mining Study Using VOSviewer and R Package.
Khormi AH. Khormi AH. Br J Hosp Med (Lond). 2026 Apr 21;87(4):53141. doi: 10.31083/BJHM53141. Br J Hosp Med (Lond). 2026. PMID: 42052999 Free article.
This study aimed to investigate maternal-fetal antibiotic dynamics in suspected chorioamnionitis (MFADESC) using bibliometric data mining tools to determine key research themes and trends. ...
This study aimed to investigate maternal-fetal antibiotic dynamics in suspected chorioamnionitis (MFADESC) using bibliometric data mi …
Expert Consensus on the Diagnosis and Management of Cervical Insufficiency in China (2026 Revision).
Society of Perinatal Medicine, Chinese Medical Association; Obstetrics Group, Society of Obstetrics and Gynecology, Chinese Medical Association. Society of Perinatal Medicine, Chinese Medical Association; Obstetrics Group, Society of Obstetrics and Gynecology, Chinese Medical Association. Matern Fetal Med. 2026 Apr;8(2):104-116. doi: 10.1097/FM9.0000000000000343. Epub 2026 Mar 20. Matern Fetal Med. 2026. PMID: 42051655 Free PMC article.
This consensus provides evidence-based analysis and recommendations on key clinical issues including the diagnosis of cervical incompetence, indications for cervical cerclage, surgical techniques, timing of intervention, perioperative management, and adjunctive therapies, …
This consensus provides evidence-based analysis and recommendations on key clinical issues including the diagnosis of cervical incompetence, …
Do human B-1 lymphocytes truly exist?
Martínez-Gutiérrez MI, Cañedo-Solares I, Gómez-Chávez F, Molina-López LM, Flores-Rabasa R, Magdaleno-Villanueva JA, León-Pedroza JI, Correa D. Martínez-Gutiérrez MI, et al. Front Immunol. 2026 Apr 13;17:1810144. doi: 10.3389/fimmu.2026.1810144. eCollection 2026. Front Immunol. 2026. PMID: 42051506 Free PMC article. Review.
These human B-1 cells are present in blood, skin, pleural and peritoneal cavities, the spleen, and several fetal tissues. They exhibit tonic intracellular signaling and spontaneously secrete antibodies that share certain specificities with classical natural antibodies (e.g …
These human B-1 cells are present in blood, skin, pleural and peritoneal cavities, the spleen, and several fetal tissues. They exhibi …
Severe Hypokalemia Complicated by Wernicke's Encephalopathy and Hypoxic-Ischemic Brain Injury in Pregnancy: A Case from a Resource-Limited ICU.
Tahajud OA, Elmi AH, Ahmed OH, Ali HA. Tahajud OA, et al. Int Med Case Rep J. 2026 Apr 21;19:597732. doi: 10.2147/IMCRJ.S597732. eCollection 2026. Int Med Case Rep J. 2026. PMID: 42051410 Free PMC article.
Her clinical course was further complicated by rhabdomyolysis, hepatic dysfunction, thrombocytopenia, and intrauterine fetal demise. Following prolonged ventilatory support and tracheostomy, she achieved partial neurological recovery and was discharged with ongoing rehabil …
Her clinical course was further complicated by rhabdomyolysis, hepatic dysfunction, thrombocytopenia, and intrauterine fetal demise. …
Maternal Chrono-Nutrition and Placental DNA Methylation: The BiSC Study.
Llauradó-Pont J, Aguilar-Lacasaña S, Cosin-Tomas M, Julvez J, Contreras-Rodríguez O, Kogevinas M, Papantoniou K, Gallo E, Harding BN, Vrijheid M, Dadvand P, Bustamante M, Lassale C. Llauradó-Pont J, et al. Mol Nutr Food Res. 2026 May;70(9):e70465. doi: 10.1002/mnfr.70465. Mol Nutr Food Res. 2026. PMID: 42051041 Free PMC article.
Hits included cg13147785 (E2F8), linked to placental cell cycle regulation, cg17665505 (DAP) and cg18303215 (ABCG5), associated with smoking and lung diseases in adults. To conclude, maternal chrono-nutrition was associated with some CpGs in the placenta, particularly time …
Hits included cg13147785 (E2F8), linked to placental cell cycle regulation, cg17665505 (DAP) and cg18303215 (ABCG5), associated with smoking …
Placental hormones, IGF-1, and early-life growth: endocrine links between birth size and infant metabolic programming-a systematic review.
Soliman AT, Alyafei F, Alaaraj N, Ahmed S, Hamed N, Elsiddig S. Soliman AT, et al. Eur J Pediatr. 2026 Apr 28;185(5):313. doi: 10.1007/s00431-026-06985-5. Eur J Pediatr. 2026. PMID: 42050034 Free PMC article. Review.
The purpose of this study is to systematically review human evidence linking placental hormones and IGF-1 with fetal growth, birth size, and early-life metabolic programming, and to identify disease-specific translational signals relevant to fetal growth restriction …
The purpose of this study is to systematically review human evidence linking placental hormones and IGF-1 with fetal growth, birth si …
Placental mesenchymal dysplasia: diagnostic and management insights from a case report and literature review.
Luo Q, Qin Y, Zeng Z, Huang Y, Sun X, Zheng W. Luo Q, et al. Arch Gynecol Obstet. 2026 Apr 28;313(1):183. doi: 10.1007/s00404-026-08416-0. Arch Gynecol Obstet. 2026. PMID: 42049980 Free PMC article. Review.
Some mothers may develop complications such as hypertensive disorders of pregnancy, while adverse perinatal outcomes-such as preterm delivery or stillbirth due to fetal distress or malformations-may also occur. However, a considerable proportion of maternal and fetal …
Some mothers may develop complications such as hypertensive disorders of pregnancy, while adverse perinatal outcomes-such as preterm deliver …
Time-Threshold Dose-Response Relationship Between Duration of Premature Rupture of Membranes and Maternal, Neonatal, and Laboratory Evidence of Infection: A Systematic Review and Meta-Analysis.
Hassan IS, Nassef AH, Emam MSM, Alwaseef MAE, Madbouly KSEF, Eltrafi NHI, Agaba NFM, Barakat SA, Ali AR, Othman AMAEG, Ageez MN, Omar A, Breika RMYM, Yousef DHAE, Okasha RFA, Gouda NS, Hashish E, Ali DF, Mohamed HS, Ateya RM, Nasr HM, Hegazy HA, Abd Elhalim AEM, Abdelmotogaly HSM, Abdelghany RS. Hassan IS, et al. Clin Ter. 2026 May-Jun;177(3):642-651. doi: 10.7417/CT.2026.2052. Clin Ter. 2026. PMID: 42047155 Free article.
Plasma Asymmetric Dimethylarginine as a Biomarker of Disease Severity and Therapeutic Response in Neonatal Persistent Pulmonary Hypertension: An Observational Prospective Case-Control Study.
Abdou RM, El Wakeel MA, El-Kassas GM, Ali WH, Ahmed HM, Agha M, Abdel Fatah MAA, Abdelghany RS, Madbouly KSEF, Mohamad HB, Hassan IS, Ahmed MAM, Okda HT, Ismail HAM. Abdou RM, et al. Clin Ter. 2026 May-Jun;177(3):539-548. doi: 10.7417/CT.2026.2039. Clin Ter. 2026. PMID: 42047141 Free article.
The CuRe Trial: Groundbreaking Innovation Raising Scientific and Ethical Questions.
Sluzala ZB. Sluzala ZB. Discoveries (Craiova). 2026 Apr 20;14(2):e228. doi: 10.15190/d.2026.7. eCollection 2026 Apr-Jun. Discoveries (Craiova). 2026. PMID: 42046825 Free PMC article.
Preliminary data for the Cellular Therapy for In Utero Repair of Myelomeningocele (CuRe) Trial have recently been published. These data showcase innovation in fetal surgery but introduce ethical questions regarding tissue sourcing. The CuRe Trial utilizes early gest …
Preliminary data for the Cellular Therapy for In Utero Repair of Myelomeningocele (CuRe) Trial have recently been published. These da …
The role of large language models in the diagnosis and management of obstetric patients: a pilot feasibility study using simulated obstetric cases.
Psilopatis I, Redling K, Filippi V, Kappos S, Emons J, Mosimann B, Zwimpfer TA. Psilopatis I, et al. Arch Gynecol Obstet. 2026 Apr 27;313(1):174. doi: 10.1007/s00404-026-08423-1. Arch Gynecol Obstet. 2026. PMID: 42045418 Free PMC article.
METHODS: Five fictional obstetric patient cases, encompassing a range of clinical presentations (preeclampsia, fetal growth restriction, preterm premature rupture of membranes, vaginal bleeding, and abdominal trauma), were presented to three LLMs: Chat-GPT (OpenAI), Gemini …
METHODS: Five fictional obstetric patient cases, encompassing a range of clinical presentations (preeclampsia, fetal growth restricti …
Correlates of prenatal heavy metal contamination in Lebanese infants using cord blood analysis.
Whaibeh E, Hanna JA, Kuta J, Aouad N, Yaghi N, Nader AA, Khalil C, Tayeh GA, Mrad M. Whaibeh E, et al. Sci Rep. 2026 Apr 28. doi: 10.1038/s41598-026-46981-1. Online ahead of print. Sci Rep. 2026. PMID: 42045341 Free article.
Exposure to heavy metals during pregnancy can disrupt fetal development and cause adverse health effects. However, data on fetal exposure in Lebanon remain scarce. ...While causal inference cannot be established, this study underscores the importance of documenting …
Exposure to heavy metals during pregnancy can disrupt fetal development and cause adverse health effects. However, data on fetal …
Moderate neuroprotection of combination cell therapy in fetal growth restricted newborns at postnatal day 10.
Chand KK, Beecher K, Nano R, Sim SL, Sun J, Stokes-Marshall P, Macfarlane L, Luff J, Musco H, Colditz PB, Khosrotehrani K, Patel J, Wixey JA. Chand KK, et al. Stem Cells Transl Med. 2026 Apr 27;15(5):szag019. doi: 10.1093/stcltm/szag019. Stem Cells Transl Med. 2026. PMID: 42045131 Free PMC article.
Infants with fetal growth restriction (FGR) are at increased risk of adverse neurodevelopmental conditions, including motor, learning, and behavioral deficits. ...Here, we aimed to examine whether this novel therapy presented sustained efficacy in newborn pigs that …
Infants with fetal growth restriction (FGR) are at increased risk of adverse neurodevelopmental conditions, including motor, learning …
A selection model for umbilical cord blood units with high isolation yield of total nucleated and CD34+ cells.
Pham VM, Nguyen HV, Dang QT, Nguyen SK, Ngo MHV, Tra APN, Truong HTT, Pham HM, Mai DV, Le OH, Huynh LT. Pham VM, et al. Stem Cells Transl Med. 2026 Apr 27;15(5):szag031. doi: 10.1093/stcltm/szag031. Stem Cells Transl Med. 2026. PMID: 42045129 Free PMC article.
BACKGROUND: Cord blood is an important hematopoietic stem cell source for treating over 80 FDA-approved diseases, driving demand for HSC-containing-umbilical cord blood (UCB) unit cryopreservation for future use. ...
BACKGROUND: Cord blood is an important hematopoietic stem cell source for treating over 80 FDA-approved diseases, driving demand for …
Yellow Fever in Pregnancy: A Comprehensive Review of the Clinical Implications and Vaccination in the Context of the 2024-2026 Americas Outbreak.
Rodríguez-Morales AJ, Acevedo-Jimenez K, Guevara ME, Chang-Cojulun A, Brea-Del Castillo J, Palmieri M, Avila-Agüero ML, de Novales FJM, Torres-Martínez C, Olaya SX, Angulo SD, Cardona-Ospina JA, Debbag R, Espinal C, Cabrera M, Acosta-España JD, López-Delgado DS, Solarte-Portilla MA, Fraile O, Drummond T, Angerami RN, Muñoz FM, Benítez I, Luz K, López-Zambrano MA, Hernán-García C, Sánchez-Carmona DL, Cortes L, Vargas H, Zambrano L, Calderón-Medina DL, Hernández-Ramírez DA, Katime A, Faccini-Martínez ÁA, Medina-Lozano LJ, Porras-Pedroza BE, Biscayart C, Carvajal A, Soto-Ávila LM, Hernández M, Ulloa-Gutierrez R, Naranjo-Lara L, Mojica JA, Collins MH, Maldonado H, Safadi MAP, Chacon-Cruz E, Suárez JA. Rodríguez-Morales AJ, et al. Trop Med Infect Dis. 2026 Mar 30;11(4):92. doi: 10.3390/tropicalmed11040092. Trop Med Infect Dis. 2026. PMID: 42042953 Free PMC article. Review.
Physiological and immunological changes during gestation may influence host responses to infection; however, current evidence does not demonstrate increased susceptibility to or severity of yellow fever during pregnancy. Adverse materno-fetal outcomes, including miscarriag …
Physiological and immunological changes during gestation may influence host responses to infection; however, current evidence does not demon …
Monoclonal Antibodies in Pregnancy of Patients with Systemic Lupus Erythematosus: Friend or Foe? A Case Report of a Patient with Multiple Pregnancies.
Orlandi C, Tincani A, Fredi M, Andreoli L, Crisafulli F, Moschetti L, Nalli C, Lazzaroni MG, Taglietti M, Filippini M, Zatti S, Picciau L, Franceschini F, Cavazzana I. Orlandi C, et al. Antibodies (Basel). 2026 Apr 8;15(2):32. doi: 10.3390/antib15020032. Antibodies (Basel). 2026. PMID: 42041391 Free PMC article.
Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women of childbearing age, and active disease during pregnancy is associated with increased maternal and fetal morbidity. Belimumab is an effective biologic therapy for active SLE …
Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women of childbearing age, and active disease during …
SRSF1 haploinsufficiency drives the neurodevelopmental phenotype of the 17q22 deletion syndrome.
Wu Y, Gao C, Chen Z, Liu F, Yuan J, Cheng W. Wu Y, et al. Front Med (Lausanne). 2026 Apr 10;13:1750790. doi: 10.3389/fmed.2026.1750790. eCollection 2026. Front Med (Lausanne). 2026. PMID: 42040609 Free PMC article.
CONCLUSION: Integrating the genetic findings in this fetus, the abnormal ultrasound structural phenotype, and the clinical characteristics of existing cases, we conclude that SRSF1 haplotype deficiency is the fundamental genetic cause underlying the observed fetal ultrasou …
CONCLUSION: Integrating the genetic findings in this fetus, the abnormal ultrasound structural phenotype, and the clinical characteristics o …
Wernicke's Encephalopathy Secondary to Hyperemesis Gravidarum in Pregnancy: A Case Report.
Mahato A, Parajuli S, Ghimire B, Basnet B, Sigdel B, Yadav BK, Jha SK. Mahato A, et al. Clin Case Rep. 2026 Apr 24;14:e72607. doi: 10.1002/ccr3.72607. eCollection 2026 May. Clin Case Rep. 2026. PMID: 42040370 Free PMC article.
This case highlights the importance of maintaining a high index of suspicion for Wernicke's Encephalopathy in pregnant women presenting with hyperemesis gravidarum and neurological symptoms, as timely parenteral thiamine therapy can lead to favorable maternal and fetal …
This case highlights the importance of maintaining a high index of suspicion for Wernicke's Encephalopathy in pregnant women presenting with …
Stroke From Paradoxical Embolism in a Young Patient With Sickle-Cell Disease and High Fetal Hemoglobin: A Diagnostic Challenge.
Luo YH, Zuberi N, Rizzolo A, Warner M, Isnard S, Routy JP. Luo YH, et al. Clin Case Rep. 2026 Apr 24;14:e72618. doi: 10.1002/ccr3.72618. eCollection 2026 May. Clin Case Rep. 2026. PMID: 42040366 Free PMC article.
Sickle-cell disease (SCD) is characterized by abnormal hemoglobin (Hb) polymerization, leading to erythrocyte sickling and microvascular obstruction. Elevated fetal hemoglobin (HbF) levels are often associated with reduced-but still possible-vaso-occlusive complications. . …
Sickle-cell disease (SCD) is characterized by abnormal hemoglobin (Hb) polymerization, leading to erythrocyte sickling and microvascular obs …
Varicella-Zoster Virus Reactivation Presenting as Cranial Neuritis Without Rash in Late Pregnancy: A Case Report.
Košir Pogačnik R, Kofol A, Mrvič T, Dolanc Merc M. Košir Pogačnik R, et al. Case Rep Obstet Gynecol. 2026 Apr 24;2026:5236883. doi: 10.1155/crog/5236883. eCollection 2026. Case Rep Obstet Gynecol. 2026. PMID: 42040354 Free PMC article.
Early antiviral treatment is associated with favorable maternal and fetal outcomes. Only a few cases of VZV meningitis or encephalitis in pregnant patients have been reported in the literature. ...Detection of VZV DNA in cerebrospinal fluid is essential for diagnosis in at …
Early antiviral treatment is associated with favorable maternal and fetal outcomes. Only a few cases of VZV meningitis or encephaliti …
Combinatorial base editing couples disease correction with lineage amplification in hematopoietic stem and progenitor cells.
Jia K, Soupene E, Sinha R, Lesch BJ, Pendergast MA, Choi R, Zhang X, Foppiani EM, Kostamo Z, Chu SN, Sharma D, Yu X, Cordero M, Walters MC, MacKenzie TC, Sheehan VA, Cromer MK. Jia K, et al. bioRxiv [Preprint]. 2026 Apr 14:2026.04.13.718029. doi: 10.64898/2026.04.13.718029. bioRxiv. 2026. PMID: 42039379 Free PMC article. Preprint.
First-generation genome editing therapies have largely focused on correcting or compensating for pathogenic variants. However, as these approaches enter the clinic, emerging biological constraints limit maximal therapeutic impact. ...We develop a multiplex base editing str …
First-generation genome editing therapies have largely focused on correcting or compensating for pathogenic variants. However, as the …
Assessment of Apparent Diffusion Coefficient and Perfusion Values of the Placenta in Intrauterine Growth Restriction by Using 3Tesla Magnetic Resonance Imaging (MRI) in an Indian Population: A Pilot Study.
Chandra Sekhar P, Chaitanya Deep D. Chandra Sekhar P, et al. Ethiop J Health Sci. 2026 Jan;36(1):33-40. doi: 10.4314/ejhs.v36i1.6. Ethiop J Health Sci. 2026. PMID: 42039320 Free PMC article.
BACKGROUND: Intrauterine growth restriction (IUGR) is defined as an estimated fetal weight below the 10th percentile for gestational age and is commonly associated with placental insufficiency and abnormal fetoplacental oxygenation. ...
BACKGROUND: Intrauterine growth restriction (IUGR) is defined as an estimated fetal weight below the 10th percentile for gestational …
The Association between Serum Biochemical Markers and Early Amniocentesis in Diagnosing Chromosomal Anomalies: A Cross-Sectional Study in Southern Iran, 2021-2022.
Kasraeian M, Dianatpour M, Zare M, Zare M, Faraji A, Vafaei H, Asadi N, Bazrafshan K. Kasraeian M, et al. Iran J Med Sci. 2026 Mar 1;51(3):186-195. doi: 10.30476/ijms.2025.107579.4208. eCollection 2026 Mar. Iran J Med Sci. 2026. PMID: 42039225 Free PMC article.
METHODS: In a cross-sectional study, data from pregnant women in the first trimester undergoing amniocentesis test for the diagnosis of fetal genetic diseases were collected during 2021-2022. Maternal weight, maternal age, gestational age at nuchal translucency (NT) …
METHODS: In a cross-sectional study, data from pregnant women in the first trimester undergoing amniocentesis test for the diagnosis of f …
Neutrophil extracellular traps in pregnancy complications.
Wang C, Zhang M. Wang C, et al. Front Immunol. 2026 Apr 10;17:1798749. doi: 10.3389/fimmu.2026.1798749. eCollection 2026. Front Immunol. 2026. PMID: 42039209 Free PMC article. Review.
Under normal physiological conditions during pregnancy, appropriately regulated NET formation at the maternal-fetal interface functions as a crucial antimicrobial defense mechanism. However, emerging evidence indicates that excessive NET formation or defective clearance is …
Under normal physiological conditions during pregnancy, appropriately regulated NET formation at the maternal-fetal interface functio …
Comparative Effectiveness of Azithromycin versus Erythromycin for Latency Prolongation in Preterm Prelabor Rupture of Membranes < 34 Weeks of Gestation.
Chawanpaiboon S, Pooliam J. Chawanpaiboon S, et al. Int J Womens Health. 2026 Apr 21;18:603582. doi: 10.2147/IJWH.S603582. eCollection 2026. Int J Womens Health. 2026. PMID: 42038990 Free PMC article.
Although azithromycin is increasingly used as an alternative to erythromycin for latency antibiotic therapy, comparative data remain limited. This study evaluated whether azithromycin is associated with latency duration and maternal-neonatal outcomes comparable to those of …
Although azithromycin is increasingly used as an alternative to erythromycin for latency antibiotic therapy, comparative data remain …
Comparative Analysis of Fetal Kidney Length, Descending Colon Diameter, and Arterial Indices in Intrauterine Growth Restriction Versus Normal Growth Fetuses: A Case-control Study : Fetal Kidney Length, Colon Diameter, and Arterial Indices in Growth-Restricted vs. Normal Fetuses.
Abdolrazagh Nejad H, Mohammadifard M, Mirgholami A, Bijary B. Abdolrazagh Nejad H, et al. Galen Med J. 2025 Apr 16;14:e3641. doi: 10.31661/gmj.v14i.3641. eCollection 2025. Galen Med J. 2025. PMID: 42038920 Free PMC article.
BACKGROUND: Intrauterine growth restriction (IUGR) refers to poor fetal growth characterized by a multitude of neonatal complications, necessitating timely diagnosis and intervention. ...MATERIALS AND METHODS: In this case-control study, a total of 60 participants, 30 preg …
BACKGROUND: Intrauterine growth restriction (IUGR) refers to poor fetal growth characterized by a multitude of neonatal complications …
Early-life mercury exposure and allergic diseases in childhood: systematic review and meta-analysis.
Liang Q, Liu M, Mao H. Liang Q, et al. Front Pediatr. 2026 Apr 9;14:1776559. doi: 10.3389/fped.2026.1776559. eCollection 2026. Front Pediatr. 2026. PMID: 42038240 Free PMC article. Review.
BACKGROUND: Mercury is a persistent environmental contaminant that can cross the placenta and accumulate in fetal tissues. While its neurotoxic effects are well established, its potential association with allergic diseases in children remains unclear. ...Studies fro …
BACKGROUND: Mercury is a persistent environmental contaminant that can cross the placenta and accumulate in fetal tissues. While its …
Association of the Disheveled 2 (DVL2) Gene c.2044delC Variant with Increased Risk of Canine Cleft Palate.
Donner J, Hytönen M, Freyer J, Lohi H, Foran RC, Forman OP. Donner J, et al. Anim Genet. 2026 Jun;57(3):e70101. doi: 10.1002/age.70101. Anim Genet. 2026. PMID: 42037250 Free PMC article.
Canine congenital cleft palate is one of the most common craniofacial anomalies in dogs, characterized by a failure of the palatal shelves to fuse properly during fetal development, leading to abnormal communication between the oral and nasopharyngeal cavities. ...
Canine congenital cleft palate is one of the most common craniofacial anomalies in dogs, characterized by a failure of the palatal shelves t …
Third trimester hydrops fetalis as the presentation leads to prenatal diagnosis of familial hemophagocytic lymphohistiocytosis.
Chen F, Li DZ. Chen F, et al. Taiwan J Obstet Gynecol. 2026 May;65(3):650-651. doi: 10.1016/j.tjog.2024.10.029. Taiwan J Obstet Gynecol. 2026. PMID: 42036215 Free article.
The follow-up ultrasound at 32 weeks showed features of hydrops fetalis with pleural effusions, ascites, skin edema and polyhydramnios. Fetal blood sampling via cordocentesis showed a mild anemia (hemoglobin-100 g/L), thrombocytopenia (platelets-12 10(9)/L) and normal whit …
The follow-up ultrasound at 32 weeks showed features of hydrops fetalis with pleural effusions, ascites, skin edema and polyhydramnios. F …
Pregnancy in a woman with down syndrome (47, XX, +21) and a euploid fetus: implications for prenatal diagnosis and counseling.
Jin C, Chen X, Lei M, Liu X, Hui H, Jiang W, Li X, Deng P, Yu X. Jin C, et al. Taiwan J Obstet Gynecol. 2026 May;65(3):587-591. doi: 10.1016/j.tjog.2025.11.024. Taiwan J Obstet Gynecol. 2026. PMID: 42036196 Free article.
CASE REPORT: A 24-year-old primigravida with cytogenetically confirmed DS (47, XX, +21) was referred at 17 weeks' gestation. Amniocentesis revealed a euploid fetal karyotype (46, XX) with no pathogenic copy-number variants. A comprehensive fetal anatomical survey wa …
CASE REPORT: A 24-year-old primigravida with cytogenetically confirmed DS (47, XX, +21) was referred at 17 weeks' gestation. Amniocentesis r …
The association between non-invasive prenatal testing and first-trimester preeclampsia screening.
Hsu RJ, Huang CY, Huang PC, Liu CF, Chang FW. Hsu RJ, et al. Taiwan J Obstet Gynecol. 2026 May;65(3):455-464. doi: 10.1016/j.tjog.2025.07.032. Taiwan J Obstet Gynecol. 2026. PMID: 42036179 Free article.
CONCLUSION: Fetal chromosomal abnormalities may indicate increased risk for PES parameters and risk assessments. Reduced NIPT fetal fraction in high-risk PES suggests potential placental dysfunction. Combining PES parameters and NIPT fetal fraction may provid …
CONCLUSION: Fetal chromosomal abnormalities may indicate increased risk for PES parameters and risk assessments. Reduced NIPT feta …
Emerging threat of Oropouche virus: Clinical features, experimental models, and virulence.
Alkan C, Ikegami T. Alkan C, et al. Virulence. 2026 Dec;17(1):2664956. doi: 10.1080/21505594.2026.2664956. Epub 2026 Apr 30. Virulence. 2026. PMID: 42035480 Free PMC article. Review.
However, the explosive 2023-2025 outbreak expanded well beyond the Amazon region, including into the Caribbean, and was associated with a broader clinical spectrum encompassing meningoencephalitis, Guillain - Barre syndrome, persistent viral infection, lethal hemorrhagic fever, …
However, the explosive 2023-2025 outbreak expanded well beyond the Amazon region, including into the Caribbean, and was associated with a br …
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