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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 2
1997 3
1998 2
1999 1
2000 2
2002 1
2003 1
2004 3
2005 5
2006 5
2007 2
2008 1
2009 2
2010 3
2011 3
2012 4
2013 2
2014 3
2015 2
2016 2
2017 1
2018 2
2019 4
2020 3
2021 4
2022 0
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55 results
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Page 1
Natural products in drug discovery: advances and opportunities.
Atanasov AG, Zotchev SB, Dirsch VM; International Natural Product Sciences Taskforce, Supuran CT. Atanasov AG, et al. Nat Rev Drug Discov. 2021 Mar;20(3):200-216. doi: 10.1038/s41573-020-00114-z. Epub 2021 Jan 28. Nat Rev Drug Discov. 2021. PMID: 33510482 Free PMC article. Review.
Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms.
Okorji UP, Velagapudi R, El-Bakoush A, Fiebich BL, Olajide OA. Okorji UP, et al. Mol Neurobiol. 2016 Nov;53(9):6426-6443. doi: 10.1007/s12035-015-9543-1. Epub 2015 Nov 25. Mol Neurobiol. 2016. PMID: 26607631
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) activity and Abeta levels were measured with ELISA kits. Protein levels of targets in nuclear factor kappa B (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK) signalling, as well as heme oxygenase-1 ( …
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) activity and Abeta levels were measured with ELISA kits. Protein levels of ta …
Inhibition of Neuroinflammation in LPS-Activated Microglia by Cryptolepine.
Olajide OA, Bhatia HS, de Oliveira AC, Wright CW, Fiebich BL. Olajide OA, et al. Evid Based Complement Alternat Med. 2013;2013:459723. doi: 10.1155/2013/459723. Epub 2013 May 8. Evid Based Complement Alternat Med. 2013. PMID: 23737832 Free PMC article.
Further experiments on intracellular signalling mechanisms show that I kappa B-independent inhibition of NF- kappa B nuclear translocation contributes to the anti-neuroinflammatory actions of cryptolepine. ...Taken together, our results suggest that cryptolepine inh …
Further experiments on intracellular signalling mechanisms show that I kappa B-independent inhibition of NF- kappa B nuclear t …
Hypericin-an inhibitor of proteasome function.
Pajonk F, Scholber J, Fiebich B. Pajonk F, et al. Cancer Chemother Pharmacol. 2005 May;55(5):439-46. doi: 10.1007/s00280-004-0933-8. Epub 2005 Jan 26. Cancer Chemother Pharmacol. 2005. PMID: 15672261
The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells.
Lieb K, Fiebich BL, Berger M, Bauer J, Schulze-Osthoff K. Lieb K, et al. J Immunol. 1997 Nov 15;159(10):4952-8. J Immunol. 1997. PMID: 9366421
Substance P-induced NF-kappa B activation was associated with the increased mRNA expression and secretion of IL-8, an NF-kappa B-controlled target gene. ...Our results suggest that NF-kappa B may be an important component controlling neurogenic inflammation w …
Substance P-induced NF-kappa B activation was associated with the increased mRNA expression and secretion of IL-8, an NF-kappa B
Effects of a Novel GPR55 Antagonist on the Arachidonic Acid Cascade in LPS-Activated Primary Microglial Cells.
Saliba SW, Gläser F, Deckers A, Keil A, Hurrle T, Apweiler M, Ferver F, Volz N, Endres D, Bräse S, Fiebich BL. Saliba SW, et al. Int J Mol Sci. 2021 Mar 2;22(5):2503. doi: 10.3390/ijms22052503. Int J Mol Sci. 2021. PMID: 33801492 Free PMC article.
We show here that KIT 10 potently prevented the release of prostaglandin E(2) (PGE(2)), reduced microsomal PGE(2) synthase (mPGES-1) and cyclooxygenase-2 (COX-2) synthesis, and inhibited the phosphorylation of Ikappa B-alpha (IkappaB-alpha), a crucial upstream step of the …
We show here that KIT 10 potently prevented the release of prostaglandin E(2) (PGE(2)), reduced microsomal PGE(2) synthase (mPGES-1) and cyc …
55 results