Figler H - Search Results

1

2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding: new 3, 4-, and 5-modifications.

Lütjens H, Zickgraf A, Figler H, Linden J, Olsson RA, Scammells PJ. Lütjens H, et al. Among authors: figler h. J Med Chem. 2003 May 8;46(10):1870-7. doi: 10.1021/jm020295m. J Med Chem. 2003. PMID: 12723950

2

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

Aurelio L, Valant C, Figler H, Flynn BL, Linden J, Sexton PM, Christopoulos A, Scammells PJ. Aurelio L, et al. Among authors: figler h. Bioorg Med Chem. 2009 Oct 15;17(20):7353-61. doi: 10.1016/j.bmc.2009.08.024. Epub 2009 Aug 20. Bioorg Med Chem. 2009. PMID: 19751980 Free PMC article.

3

2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists.

Ferguson GN, Valant C, Horne J, Figler H, Flynn BL, Linden J, Chalmers DK, Sexton PM, Christopoulos A, Scammells PJ. Ferguson GN, et al. Among authors: figler h. J Med Chem. 2008 Oct 9;51(19):6165-72. doi: 10.1021/jm800557d. Epub 2008 Sep 5. J Med Chem. 2008. PMID: 18771255 Free PMC article.

4

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.

Aurelio L, Figler H, Flynn BL, Linden J, Scammells PJ. Aurelio L, et al. Among authors: figler h. Bioorg Med Chem. 2008 Feb 1;16(3):1319-27. doi: 10.1016/j.bmc.2007.10.065. Epub 2007 Oct 23. Bioorg Med Chem. 2008. PMID: 17980606

5

Dual acting antioxidant A1 adenosine receptor agonists.

Gregg A, Bottle SE, Devine SM, Figler H, Linden J, White P, Pouton CW, Urmaliya V, Scammells PJ. Gregg A, et al. Among authors: figler h. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5437-41. doi: 10.1016/j.bmcl.2007.07.035. Epub 2007 Jul 25. Bioorg Med Chem Lett. 2007. PMID: 17689079

6

2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers.

Nikolakopoulos G, Figler H, Linden J, Scammells PJ. Nikolakopoulos G, et al. Among authors: figler h. Bioorg Med Chem. 2006 Apr 1;14(7):2358-65. doi: 10.1016/j.bmc.2005.11.018. Epub 2005 Nov 28. Bioorg Med Chem. 2006. PMID: 16314104

7

6-aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency.

Chordia MD, Zigler M, Murphree LJ, Figler H, Macdonald TL, Olsson RA, Linden J. Chordia MD, et al. Among authors: figler h. J Med Chem. 2005 Aug 11;48(16):5131-9. doi: 10.1021/jm049132j. J Med Chem. 2005. PMID: 16078833

8

Allosteric enhancers of A1 adenosine receptors increase receptor-G protein coupling and counteract Guanine nucleotide effects on agonist binding.

Figler H, Olsson RA, Linden J. Figler H, et al. Mol Pharmacol. 2003 Dec;64(6):1557-64. doi: 10.1124/mol.64.6.1557. Mol Pharmacol. 2003. PMID: 14645687

9

2-Amino-3-aroyl-4,5-alkylthiophenes: agonist allosteric enhancers at human A(1) adenosine receptors.

Tranberg CE, Zickgraf A, Giunta BN, Luetjens H, Figler H, Murphree LJ, Falke R, Fleischer H, Linden J, Scammells PJ, Olsson RA. Tranberg CE, et al. Among authors: figler h. J Med Chem. 2002 Jan 17;45(2):382-9. doi: 10.1021/jm010081p. J Med Chem. 2002. PMID: 11784142

10

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.

Devine SM, Gregg A, Figler H, McIntosh K, Urmaliya V, Linden J, Pouton CW, White PJ, Bottle SE, Scammells PJ. Devine SM, et al. Among authors: figler h. Bioorg Med Chem. 2010 May 1;18(9):3078-87. doi: 10.1016/j.bmc.2010.03.047. Epub 2010 Mar 27. Bioorg Med Chem. 2010. PMID: 20385496

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