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The role of the synovial fibroblast in rheumatoid arthritis pathogenesis.
Turner JD, Filer A. Turner JD, et al. Among authors: filer a. Curr Opin Rheumatol. 2015 Mar;27(2):175-82. doi: 10.1097/BOR.0000000000000148. Curr Opin Rheumatol. 2015. PMID: 25603041 Review.
The prevalence of patients with rheumatoid arthritis in the West Midlands fulfilling the BSR criteria for anti-tumour necrosis factor therapy: an out-patient study.
Yee CS, Filer A, Pace A, Douglas K, Situnayake D, Rowe IF; West Midlands Rheumatology Services and Training Committee. Yee CS, et al. Among authors: filer a. Rheumatology (Oxford). 2003 Jul;42(7):856-9. doi: 10.1093/rheumatology/keg231. Epub 2003 Mar 31. Rheumatology (Oxford). 2003. PMID: 12730544

METHODS: Data were collected over a 2-week period in adult out-patient departments of 12 centres. A questionnaire was completed at each patient review. ...Those with a DAS-28 score of < or = 5.1 were significantly more likely to have been taking steroids c

METHODS: Data were collected over a 2-week period in adult out-patient departments of 12 centres. A questionnaire was complete …
Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns.
Parsonage G, Falciani F, Burman A, Filer A, Ross E, Bofill M, Martin S, Salmon M, Buckley CD. Parsonage G, et al. Among authors: filer a. Thromb Haemost. 2003 Oct;90(4):688-97. doi: 10.1160/TH03-04-0208. Thromb Haemost. 2003. PMID: 14515190
Detection of differentially expressed genes in synovial fibroblasts by restriction fragment differential display.
Scaife S, Brown R, Kellie S, Filer A, Martin S, Thomas AM, Bradfield PF, Amft N, Salmon M, Buckley CD. Scaife S, et al. Among authors: filer a. Rheumatology (Oxford). 2004 Nov;43(11):1346-52. doi: 10.1093/rheumatology/keh347. Epub 2004 Aug 3. Rheumatology (Oxford). 2004. PMID: 15292528
Differential gene expression was confirmed by reverse transcription-polymerase chain reaction and immunohistochemistry using a variety of synovial fibroblasts, including cells from patients with osteoarthritis and self-limiting parvovirus arthritis. ...
Differential gene expression was confirmed by reverse transcription-polymerase chain reaction and immunohistochemistry using a variet …
Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease.
Buckley CD, Filer A, Haworth O, Parsonage G, Salmon M. Buckley CD, et al. Among authors: filer a. Ann Rheum Dis. 2004 Nov;63 Suppl 2(Suppl 2):ii92-ii95. doi: 10.1136/ard.2004.028332. Ann Rheum Dis. 2004. PMID: 15479882 Free PMC article. Review.
Despite the use of effective anti-inflammatory agents and disease modifying drugs, a significant proportion of patients with rheumatoid arthritis continue to have resistant disease. Complete clinical remission is unusual for more than six months and a formal cure of …
Despite the use of effective anti-inflammatory agents and disease modifying drugs, a significant proportion of patients with rheumato …
The role of leukocyte-stromal interactions in chronic inflammatory joint disease.
Burman A, Haworth O, Bradfield P, Parsonage G, Filer A, Thomas AM, Amft N, Salmon M, Buckley CD. Burman A, et al. Among authors: filer a. Joint Bone Spine. 2005 Jan;72(1):10-6. doi: 10.1016/j.jbspin.2004.03.009. Joint Bone Spine. 2005. PMID: 15681242 Free PMC article. Review.
Rheumatoid arthritis (RA) is a debilitating, chronic, persistent inflammatory disease that is characterised by painful and swollen joints. The aetiology of RA is unknown, however whereas past research has concentrated on the role of immune or inflammatory infiltrating cell …
Rheumatoid arthritis (RA) is a debilitating, chronic, persistent inflammatory disease that is characterised by painful and swollen jo …
A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium.
Lally F, Smith E, Filer A, Stone MA, Shaw JS, Nash GB, Buckley CD, Rainger GE. Lally F, et al. Among authors: filer a. Arthritis Rheum. 2005 Nov;52(11):3460-9. doi: 10.1002/art.21394. Arthritis Rheum. 2005. PMID: 16255036 Free PMC article.
OBJECTIVE: Rheumatoid arthritis (RA) is classically thought of as a Th1, T lymphocyte-driven disease of the adaptive immune system. ...This process may depend on a previously unsuspected route of IL-6-mediated crosstalk between fibroblasts and endothelial cells....
OBJECTIVE: Rheumatoid arthritis (RA) is classically thought of as a Th1, T lymphocyte-driven disease of the adaptive immune system. . …
Progression of imaging in pancreatitis panniculitis polyarthritis (PPP) syndrome.
Price-Forbes AN, Filer A, Udeshi UL, Rai A. Price-Forbes AN, et al. Among authors: filer a. Scand J Rheumatol. 2006 Jan-Feb;35(1):72-4. doi: 10.1080/03009740500228073. Scand J Rheumatol. 2006. PMID: 16467048
Lobular panniculitis, together with a polyarthritis may complicate pancreatic disease. Abdominal symptoms are frequently absent and mis-diagnosis of the joint-skin complex can lead to inappropriate treatment in a condition with an already high mortality. We report …
Lobular panniculitis, together with a polyarthritis may complicate pancreatic disease. Abdominal symptoms are frequently absent and m …
Targeting the stromal microenvironment in chronic inflammation.
Filer A, Pitzalis C, Buckley CD. Filer A, et al. Curr Opin Pharmacol. 2006 Aug;6(4):393-400. doi: 10.1016/j.coph.2006.03.007. Epub 2006 May 8. Curr Opin Pharmacol. 2006. PMID: 16682252 Free PMC article. Review.
A characteristic feature of chronic inflammatory reactions is their persistence and predilection for certain sites. The molecular basis for such tissue tropism (as, for example, seen with metastatic spread) has until recently remained obscure, but recent studies have stron
A characteristic feature of chronic inflammatory reactions is their persistence and predilection for certain sites. The molecular bas
Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils.
Filer A, Parsonage G, Smith E, Osborne C, Thomas AM, Curnow SJ, Rainger GE, Raza K, Nash GB, Lord J, Salmon M, Buckley CD. Filer A, et al. Arthritis Rheum. 2006 Jul;54(7):2096-108. doi: 10.1002/art.21930. Arthritis Rheum. 2006. PMID: 16802344 Free PMC article.
CONCLUSION: These results suggest an important functional role for fibroblasts in the differential accumulation of leukocyte subsets in a variety of tissue microenvironments. The findings also provide a potential explanation for site-specific differences in the patt …
CONCLUSION: These results suggest an important functional role for fibroblasts in the differential accumulation of leukocyte subsets in a
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