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27 results
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Human hepatocyte transplantation for liver disease: current status and future perspectives.
Iansante V, Mitry RR, Filippi C, Fitzpatrick E, Dhawan A. Iansante V, et al. Among authors: filippi c. Pediatr Res. 2018 Jan;83(1-2):232-240. doi: 10.1038/pr.2017.284. Epub 2017 Dec 6. Pediatr Res. 2018. PMID: 29149103 Review.
Liver transplantation is the accepted treatment for patients with acute liver failure and liver-based metabolic disorders. However, donor organ shortage and lifelong need for immunosuppression are the main limitations to liver transplantation. In addit
Liver transplantation is the accepted treatment for patients with acute liver failure and liver-based metabolic disorde
Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children.
Dhawan A, Chaijitraruch N, Fitzpatrick E, Bansal S, Filippi C, Lehec SC, Heaton ND, Kane P, Verma A, Hughes RD, Mitry RR. Dhawan A, et al. Among authors: filippi c. J Hepatol. 2020 May;72(5):877-884. doi: 10.1016/j.jhep.2019.12.002. Epub 2019 Dec 13. J Hepatol. 2020. PMID: 31843649
BACKGROUND & AIMS: Liver transplantation (LT) is the most effective treatment for patients with acute liver failure (ALF), but is limited by surgical risks and the need for life-long immunosuppression. ...Liver cell (hepatocyte) transplantation is an attr …
BACKGROUND & AIMS: Liver transplantation (LT) is the most effective treatment for patients with acute liver failure (ALF), …
Clinical application of hepatocyte transplantation: current status, applicability, limitations, and future outlook.
Nguyen MP, Jain V, Iansante V, Mitry RR, Filippi C, Dhawan A. Nguyen MP, et al. Among authors: filippi c. Expert Rev Gastroenterol Hepatol. 2020 Mar;14(3):185-196. doi: 10.1080/17474124.2020.1733975. Epub 2020 Mar 2. Expert Rev Gastroenterol Hepatol. 2020. PMID: 32098516
Introduction: Hepatocyte transplantation (HT) is a promising alternative to liver transplantation for the treatment of liver-based metabolic diseases and acute liver failure (ALF). However, shortage of good-quality liver tissues, early cell loss post-i …
Introduction: Hepatocyte transplantation (HT) is a promising alternative to liver transplantation for the treatment of liver-b …
Current status of human hepatocyte transplantation and its potential for Wilson's disease.
Filippi C, Dhawan A. Filippi C, et al. Ann N Y Acad Sci. 2014 May;1315:50-5. doi: 10.1111/nyas.12386. Epub 2014 Mar 7. Ann N Y Acad Sci. 2014. PMID: 24605914 Review.
Wilson's disease (WD) is a genetic disorder of liver copper excretion leading to its accumulation in various vital organs like the liver, brain, and kidneys. ...Human hepatocyte transplantation (HTx) is increasingly used as treatment for liver-based me …
Wilson's disease (WD) is a genetic disorder of liver copper excretion leading to its accumulation in various vital organs like …
Hepatic endoderm differentiation from human embryonic stem cells.
Hannoun Z, Filippi C, Sullivan G, Hay DC, Iredale JP. Hannoun Z, et al. Among authors: filippi c. Curr Stem Cell Res Ther. 2010 Sep;5(3):233-44. doi: 10.2174/157488810791824403. Curr Stem Cell Res Ther. 2010. PMID: 20214561 Review.
There has been a major focus on developing protocols to derive functional HE from hESCs. This review focuses on human liver biology and the translation of observations of in vivo systems into developing differentiation protocols to yield hepatic endoderm. ...
There has been a major focus on developing protocols to derive functional HE from hESCs. This review focuses on human liver biology a …
Cryopreservation of Hepatocyte Microbeads for Clinical Transplantation.
Jitraruch S, Dhawan A, Hughes RD, Filippi C, Lehec SC, Glover L, Mitry RR. Jitraruch S, et al. Among authors: filippi c. Cell Transplant. 2017 Aug;26(8):1341-1354. doi: 10.1177/0963689717720050. Cell Transplant. 2017. PMID: 28901189 Free PMC article.
Intraperitoneal transplantation of hepatocyte microbeads is an attractive option for the management of acute liver failure. Encapsulation of hepatocytes in alginate microbeads supports their function and prevents immune attack of the cells. ...
Intraperitoneal transplantation of hepatocyte microbeads is an attractive option for the management of acute liver failure. Encapsula …
Improving engraftment of hepatocyte transplantation using alpha-1 antitrypsin as an immune modulator.
Lee C, Dhawan A, Iansante V, Filippi C, Mitry R, Tang J, Walker S, Fernandez DaCosta R, Sinha S, Hughes RD, Koulmanda M, Fitzpatrick E. Lee C, et al. Among authors: filippi c. J Mol Med (Berl). 2019 Apr;97(4):563-577. doi: 10.1007/s00109-019-01747-3. Epub 2019 Feb 28. J Mol Med (Berl). 2019. PMID: 30820592 Free PMC article.
For patients with non-cirrhotic liver-based metabolic disorders, hepatocyte transplantation can be an effective treatment. However, long-term function of transplanted hepatocytes following infusion has not been achieved due to insufficient numbers of hepatocytes reaching t …
For patients with non-cirrhotic liver-based metabolic disorders, hepatocyte transplantation can be an effective treatment. However, l …
COVID-19 Severity and Stroke: Correlation of Imaging and Laboratory Markers.
Katz JM, Libman RB, Wang JJ, Filippi CG, Sanelli P, Zlochower A, Gribko M, Pacia SV, Kuzniecky RI, Najjar S, Azhar S. Katz JM, et al. Among authors: filippi cg. AJNR Am J Neuroradiol. 2021 Jan;42(2):257-261. doi: 10.3174/ajnr.A6920. Epub 2020 Oct 29. AJNR Am J Neuroradiol. 2021. PMID: 33122216
Early cytotoxic effects of ochratoxin A in rat liver: a morphological, biochemical and molecular study.
Gagliano N, Donne ID, Torri C, Migliori M, Grizzi F, Milzani A, Filippi C, Annoni G, Colombo P, Costa F, Ceva-Grimaldi G, Bertelli AA, Giovannini L, Gioia M. Gagliano N, et al. Among authors: filippi c. Toxicology. 2006 Aug 15;225(2-3):214-24. doi: 10.1016/j.tox.2006.06.004. Epub 2006 Jun 10. Toxicology. 2006. PMID: 16857307 Free article.
Collagen content, determined by computer analysis of Sirius red-stained liver sections, was similar in both groups. In liver homogenates COL-I, COL-III, TIMP-1 and TGF-beta1 mRNA levels and alphaSMA were unaffected by OTA. ...OTA reduced E-cadherin and DSC-2 transcr …
Collagen content, determined by computer analysis of Sirius red-stained liver sections, was similar in both groups. In liver h …
Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure.
Newsome PN, Henderson NC, Nelson LJ, Dabos C, Filippi C, Bellamy C, Howie F, Clutton RE, King T, Lee A, Hayes PC, Plevris JN. Newsome PN, et al. Among authors: filippi c. BMC Gastroenterol. 2010 Mar 30;10:34. doi: 10.1186/1471-230X-10-34. BMC Gastroenterol. 2010. PMID: 20353598 Free PMC article.
Injured animals developed hypotension (mean arterial pressure; 40.8 +/- 5.9 vs 59 +/- 2.0 mmHg), increased cardiac output (7.26 +/- 1.86 vs 3.30 +/- 0.40 l/min) and decreased systemic vascular resistance (8.48 +/- 2.75 vs 16.2 +/- 1.76 mPa/s/m3). Dyspnoea developed as l
Injured animals developed hypotension (mean arterial pressure; 40.8 +/- 5.9 vs 59 +/- 2.0 mmHg), increased cardiac output (7.26 +/- 1.86 vs …
27 results